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Vaccine "Pentax": reviews, instructions for use, composition


vaccine for the prevention of diphtheria and tetanus adsorbed, acellular pertussis, inactivated poliomyelitis, infections caused by Haemophilus influenzae type of b conjugated


Pentaxim ®

Vaccine for the prevention of diphtheria and tetanus adsorbed, acellular pertussis, inactivated polio, infections caused by Haemophilus influenzae type of b conjugated

Lyophilisate for the preparation of suspensions for intramuscular administration of 1 dose, complete with suspension for intramuscular administration of 0.5 ml.

One dose (0.5 ml) contains:

* - does not contain phenol red

Antibiotics (streptomycin, neomycin and polymyxin B) are used in vaccine production, but are not present in detectable amounts in the final product. The vaccine is manufactured under conditions that meet the requirements of Good Manufacturing Practice (GMP).

Vaccine for the prevention of diphtheria and tetanus adsorbed, acellular pertussis, poliomyelitis inactivated (suspension for intramuscular administration): whitish turbid suspension.
Vaccine for the prevention of infection caused by Haemophilus influenzae type of bconjugated (lyophilisate for preparing suspension for intramuscular administration): white homogeneous lyophilisate.
Reconstituted vaccine: an opaque, whitish liquid that, on settling, separates into a colorless liquid to form a white precipitate, which is easily resuspended by shaking.

Mibp vaccine



Immunogenicity after primary immunization
In immunogenicity studies in children vaccinated with three doses of the drug Pentaxim, starting at three months of age, 100% of children achieved seroprotective levels of antibodies to diphtheria and tetanus antigens (≥ 0.01 IU / ml). More than 88% of children had a fourfold increase in antibody titers to the pertussis toxoid and filamentous agglutinin 1 month after the completion of the primary immunization. In the absence of a serological correlate of protection, a fourfold increase in titers after immunization can be considered a seroconversion. At least 99% of children after a course of primary immunization achieved post-vaccination titers against poliomyelitis viruses of type 1, 2 and 3, exceeding a threshold value of 5 (the reciprocal of the dilution at which seroneutralization is observed), which is considered protective. 1 month after the end of the course of primary immunization, consisting of three doses, at least in 92% of vaccinated children of the 1st year of life, the antibody titer to the capsular polysaccharide Haemophilus influenzae type of b was above the protective level of 0.15 µg / ml, necessary for short-term protection against invasive hemophilic infection. 1 month after the third vaccination, the concentration of antibodies to the capsular polysaccharide Haemophilus influenzae type of b above 1 µg / ml, necessary to ensure long-term protection against invasive hemophilic infection, was observed in more than 67% of those vaccinated.

Immunogenicity after revaccination
Immunogenicity studies in children in the second year of life, vaccinated with three doses of Pentaxim® vaccine in the framework of primary immunization, showed a high level of antibodies to all active substances of the drug after revaccination with the same vaccine. In all children, the antibody level exceeded 0.1 IU / ml for the tetanus component, and an average of fivefold increase in antibody titers to pertussis toxoid and filamentous agglutinin was observed. All children had a sufficient level of antibodies to poliomyelitis virus types 1, 2 and 3. More than 97% of children had levels of antibodies to the causative agent of diphtheria exceeding 0.1 IU / ml.
Antibody capsular polysaccharide titer Haemophilus influenzae type of b exceeded 1 µg / ml after revaccination in more than 99% of children.
These data confirm the induction of immunological memory after primary vaccination.

Primary vaccination and revaccination of children against diphtheria, tetanus, whooping cough, polio and infections caused by Haemophilus influenzae type of b (meningitis, septicemia, arthritis, epiglottitis, pneumonia, osteomyelitis, etc.).


  • Progressive encephalopathy, with or without convulsions.
  • Encephalopathy of unclear etiology that developed within 7 days after the administration of any vaccine (whole cell or acellular) containing Bordetella pertussis antigens.
  • A strong reaction that developed within 48 hours after a previous immunization with a vaccine containing a pertussis component: body temperature equal to or higher than 40 ° C, prolonged unusual crying syndrome (longer than 3 hours), febrile and afebrile seizures, hypotonic-hyporeactive syndrome.
  • Hypersensitivity to previous administration of diphtheria, tetanus, pertussis vaccines, polio vaccines or infections caused by Haemophilus influenzae type of b.
  • Established hypersensitivity to any component of the vaccine, as well as glutaraldehyde, neomycin, streptomycin and polymyxin B.
  • The disease, accompanied by fever, acute infectious or chronic disease in the acute stage. Vaccination is carried out in 2-4 weeks after recovery or in the period of convalescence or remission. With mild acute respiratory viral infections, acute intestinal diseases, etc., vaccinations are carried out immediately after the temperature is normalized.


  • If a child has a history of febrile seizures that are not associated with previous vaccinations, the body temperature should be monitored within 48 hours after vaccination and if it is increased, as prescribed by a doctor, use antipyretic (antipyretic) drugs.
  • In case of thrombocytopenia and other bleeding disorders, the introduction of a vaccine
    must be carried out with caution due to the risk of bleeding from intramuscular injection.

Since the vaccine Pentaxim® is used for vaccination of children, there are no data on the effect of the drug on the course of pregnancy and breastfeeding.


Vaccination scheme
A single dose of the vaccine is 0.5 ml.

Primary vaccination
In accordance with the National Vaccination Schedule of the Russian Federation, the primary vaccination course consists of three doses of vaccine, administered at intervals of 1.5 months: at the age of 3, 4.5 and 6 months. However, according to the recommendation of the doctor, other schemes of three-dose immunization can also be applied (for example, 2-3-4 months, 2-4-6 months, or 3-4-5 months).

Revaccination is carried out once at the age of 18 months. In case of violation of the vaccination schedule, the subsequent intervals between the introduction of the next dose of the vaccine do not change, including the interval before the 4th (revaccinating) dose - 12 months. When carrying out vaccination / revaccination are guided by the following schedule:

In all cases of violation of the vaccination schedule, the doctor should be guided by the instructions for use of the drug and the recommendations of the National Vaccination Schedule of the Russian Federation.

Mode of administration
The vaccine is administered intramuscularly. For the children of the first years of life, intramuscular injections are carried out only in the upper outer surface of the middle part of the thigh;
Do not inject intradermally or intravenously. Before the introduction, you must ensure that the needle does not penetrate into the blood vessel. For the packaging option with two separate needles (16 mm 25G, 25 mm 23G), before preparing the vaccine, one of the two needles should be firmly fixed, rotating it a quarter turn relative to the syringe. The choice of needle depends on the thickness of the subcutaneous fat layer in a child at the injection site.
To prepare the vaccine, after removing the plastic colored lid from the vial, completely inject the pre-agitated suspension for intramuscular administration (vaccine for the prevention of diphtheria, tetanus, whooping cough and polio) through a needle from a syringe into the vial with lyophilisate (a vaccine for the prevention of infection caused by Haemophilus influenzae type of b).

Shake the vial without removing the syringe from it, and wait until the lyophilisate is completely dissolved (no more than 3 minutes). The resulting suspension should be turbid and have a whitish tint. The vaccine should not be used in case of discoloration or the presence of foreign particles. A vaccine prepared in this way should be fully collected in the same syringe.
The finished vaccine should be administered immediately.

The adverse events presented below are listed in accordance with the system-organ class and frequency of occurrence. The frequency of occurrence was determined on the basis of the following criteria: very often (≥ 1/10), often (≥ 1/100 to ®, the most frequent reported reactions included irritability (15.2%) and reactions at the injection site, such as redness (11, 2%) and compaction> 2 cm (15.1%).
In a study conducted in Sweden, after three doses of Pentaxim vaccine administered at the age of 3, 5 and 12 months, the most frequent reported reactions included irritability (24.1%) and reactions at the injection site, such as redness (13.4%) and compaction (12.5%).
These signs and symptoms usually develop within 48 hours after vaccination and pass spontaneously, without requiring specific treatment.
With revaccination, there is a tendency to an increase in the incidence of common disorders and disorders at the injection site.

Metabolic and nutritional disorders
Very often: anorexia

From the psyche
Very often: nervousness (irritability), unusual crying
Often: sleep disorders
Infrequently: long crying

The nervous system
Very often: insomnia
From the gastrointestinal tract
Very often: vomiting
Often: diarrhea

General disorders and disorders at the site of administration
Very often: redness at the injection site, fever (≥ 38 ° C), soreness and swelling at the injection site
Often: seal at the injection site
Infrequently: redness and swelling (≥ 5 cm) at the injection site, fever (≥ 39 ° C)

Rarely: fever (≥ 40 ° C), diffuse swelling of one or both limbs can be observed after administration of vaccines containing capsular polysaccharide Haemophilus influenzae type of b. If such a reaction develops, then it occurs mainly after the primary vaccination and is observed during the first few hours after vaccination. This reaction may be accompanied by cyanosis, redness, transient purpura and strong crying. The listed symptoms pass spontaneously without consequences within 24 hours.

Post-registration surveillance data
Since spontaneous reports of adverse events from commercial use of the drug were received very rarely from a population with an uncertain number of patients, their frequency was classified as “frequency unknown”.

Immune system disorders
Anaphylactic reactions such as swelling of the face, angioedema, shock

On the part of the respiratory system
In deeply premature babies (born 28 weeks or earlier), within 2-3 days after vaccination, there may be cases of lengthening the time intervals between respiratory movements (see the section "Special Instructions").

The nervous system
Convulsions, accompanied or not accompanied by fever, hypotonic reactions or episodes of hypotension-hyporespondiness.

Skin and Skin Tissues
Rash, urticaria.

General disorders and disorders at the site of administration
Severe edema (≥ 5 cm) at the injection site, including edema extending over one or both joints. These reactions appeared 24-72 hours after the vaccine was introduced and could be accompanied by redness, increased skin temperature at the injection site, sensitivity or soreness at the injection site. These symptoms disappeared on their own within 3-5 days without any additional treatment. It is believed that the likelihood of developing such reactions increases depending on the number of injections of the acellular pertussis component, this probability is higher after the 4th and 5th dose of such a vaccine.

Potential adverse reactions
The company has data that after the introduction of other vaccines containing tetanus toxoid, the brachial nerve neuritis and Guillain-Barré syndrome were observed.

No data available.

With the exception of immunosuppressive therapy (see the section "Special Instructions"), there is no reliable data on possible mutual effects when used with other drugs, including with other vaccines.
The suspension containing the vaccine for the prevention of diphtheria and tetanus adsorbed, whooping cough acellular, poliomyelitis inactivated, can not be mixed with any other drugs, with the exception of the attached lyophilisate vaccine for the prevention of infection caused by Haemophilus influenzae type of b conjugated.
Reconstituted vaccine should not be mixed with other drugs and vaccines.
The physician should be informed of the recent or coincidental vaccination with the introduction to the child of any other drug (including non-prescription).

Pentaxim® vaccine does not form immunity against infections caused by other Haemophilus influenzae serotypes, as well as against meningitis of a different etiology. The physician should be informed of all cases of adverse reactions, including those not listed in this manual. Before each vaccination, to prevent possible allergic and other reactions, the doctor must clarify the state of health, history of immunization, history of the patient and immediate family (in particular - allergological), cases of side effects on previous administration of vaccines. The physician should have the drugs and tools necessary for the development of hypersensitivity reactions.

Immunosuppressive therapy or a state of immunodeficiency may cause a weak immune response to the vaccine. In these cases, it is recommended to postpone vaccination until the end of such therapy or remission of the disease. However, vaccination is recommended for people with chronic immunodeficiency (eg, HIV infection), even if the immune response may be weakened.
With a history of Guillain-Barré syndrome or brachial nerve neuritis in response to any vaccine containing tetanus toxoid, the decision on vaccination with Pentaxim® should be based on a thorough assessment of the potential benefits and possible risks. As a rule, in such cases, it is justified to complete the primary immunization in children of the first year of life (if less than 3 doses are administered).

The potential risk of developing apnea and the need to monitor breathing for 48-72 hours should be considered when conducting a primary course of immunization in very premature babies born at 28 weeks or earlier, especially in those with a history of immaturity of the respiratory system. Since the benefits of immunizing this group of children are high, vaccination should not be postponed or considered contraindicated. Since the capsular polysaccharide antigen Haemophilus influenzae type of b excreted through the kidneys, within 1-2 weeks after vaccination, a positive test for infection caused by Haemophilus influenzae type of b. During this period, other tests are needed to confirm the diagnosis of infection caused by Haemophilus influenzae type of b.

Since the vaccine Pentaxim® is used to vaccinate children, the effect of the drug on the ability to drive vehicles and engage in other potentially dangerous activities has not been studied.

Vaccine for the prevention of diphtheria and tetanus adsorbed, whooping cough acellular. inactivated polio - suspension for intramuscular injection of 0.5 ml, complete with a vaccine for the prevention of infections caused by Haemophilus influenzae type of bconjugated - lyophilisate for the preparation of suspensions for intramuscular administration of 1 dose.
One dose of the lyophilisate in a glass vial and 0.5 ml (1 dose) of the suspension in a glass syringe (with a fixed needle or without) with a capacity of 1 ml, with a chlorobromobutyl piston.
On 1 bottle and 1 syringe in the closed cellular packing (PET / PVC). If the syringe does not have a fixed needle, then 2 separate sterile needles are inserted into the package. On 1 cellular packing in an individual cardboard pack with the instruction for application.

Lyophilisate - 3 years. Suspensions - 3 years.
Do not use after the expiration date printed on the package.

Store in the refrigerator (at a temperature of from 2 to 8 ° C). Do not freeze. Keep out of the reach of children.


Sanofi Pasteur SA, France

Санофи Пастер С.А., Франция Sanofi Pasteur S.A.,
1541, avenue Marcel Merieux, 69280 Marcy l'Etoile, France
Sanofi Pasteur SA, France Sanofi Pasteur S.A.,
Pare Industriel d'Incarville, 27100 Val de Reuil, France

Sanofi Pasteur SA, France Sanofi Pasteur S.A.,
1541, avenue Marcel Merieux, 69280 Marcy l'Etoile. France
Sanofi Pasteur SA, France Sanofi Pasteur S.A.,
Pare Industriel d'Incarville, 27100 Val de Reuil, France
LLC Nanolek, Russia 612079, Kirov region.
Orychevsky district, Levintsy village, Biomedical complex

Claims of consumers to the address in Russia:
Federal Service for Health Supervision (Roszdravnadzor) 109074, Moscow. Slavyanskaya pl. 4, p. 1
and / or
Sanofi-aventis Group JSC 125009, Moscow, ul. Tverskaya, 22
and / or
LLC Nanolek, 127055, Moscow, Butyrsky Val, d.68 / 70 p.1.

Release form

Pentaxim vaccine for immunization against diphtheria (Diphtheria) and tetanus (Tetanusa) adsorbedwhooping cough (Pertussisacellular and poliomyelitis(Rolomyelitis) inactivated is a cloudy, whitish suspension. Intended for intramuscular administration, it is available in 0.5 ml in glass syringes with a volume of 1 ml (the syringe can come with a fixed needle or without it).

The vaccine for the prevention of diseases caused by HIB is a homogeneous, white lyophilized mass for preparing a suspension for i / m administration. Available in glass vials, 1 dose per vial.

Each carton pack is completed with one bottle with lyophilisate and one glass syringe with suspension, placed in a closed cell packing.

In the case when the syringe goes without a needle, the delivery set additionally includes 2 separate, sealed in a cellular packaging, sterile needles.

Pharmacodynamics and pharmacokinetics

Vaccination Pentaxim is designed to vaccinate children against tetanus (Tetanus), diphtheria (Diphtheria), poliomyelitis (Rolomyelitis), whooping cough (Pertussis) and diseases caused by hemophilic bacillus(including against septicemia, meningitis, epiglottis, pneumonia etc.). At observance of terms of a revaccination, at the imparted child the resistant immunity to the specified diseases is developed.

The manufacturer Pentaxim did not provide data on pharmacokinetics drug.

Pentaxim is characterized by good tolerability and is recommended for use in children who have reached the age of three months.

It must be borne in mind that the drug is not conducive to the formation immunity for diseases caused by others hemophilus bacillus serotypes (A, C, D, E and F), and meningitis immunityprovoked by another pathogenic microflora.

Indications for use: Pentaxim vaccination - what does it mean?

Pentaxim is used for prophylaxis in children from 3 months to 47 months 29 days tetanus(Tetanus), diphtheria(Diphtheria), poliomyelitis (Rolomyelitis), whooping cough(Pertussis) and invasive infectionscaused by HIB (including meningitis and septicemia).

The drug can be used for primary vaccination of children over one year of age for the prevention of tetanus (Tetanus), diphtheria (Diphtheria),poliomyelitis (Rolomyelitis), whooping cough (Pertussis) and invasive infectionscaused by hib. If a child older than 12 months has not previously been vaccinated against these diseases, it is recommended to introduce only Pentaxim suspension.

Also, with the use of Pentaxim, vaccination and revaccination of children who have previously been immunized with multiple doses is allowed. whole cell or acellular tetanus vaccine (Tetanus), diphtheria (Diphtheria) and whooping cough (Pertussis), subject to continued vaccination / revaccination against poliomyelitis.


Contraindications to the administration of the vaccine Pentaxim are:

  • known hypersensitivity to the components of the drug, as well as streptomycin, polymyxin B, glutaraldehyde, neomycin.
  • Progressing organic brain damage (including accompanied by convulsions).
  • Organic brain damagethat have evolved within 7 days after administration of the vaccine containing pertussis antigens (Bordetella pertussis).
  • Strong reaction to the introduction of containing pertussis component of the vaccine in the anamnesis. The reaction is associated with vaccination if it develops within 48 hours after injection. As a rule, it is expressed in the form of fever, febrileandafebrile seizures, syndrome of prolonged unusual crying, decrease in muscle tone with simultaneous neurological pathology.
  • Allergic reactions on the introduction of a vaccine against tetanus (Tetanus), diphtheria (Diphtheria), poliomyelitis (Rolomyelitis), whooping cough (Pertussis) and invasive infections, caused by HIB, in the anamnesis.
  • Acute infectious diseases, diseases that are accompanied hyperthermia, and exacerbated chronic diseases (in these cases, the child should be vaccinated only after the onset of a period of remission of a chronic disease or full recovery).

It is recommended to inoculate Pentaxim with caution:

  • children who have previously had no vaccination generalized seizures against the background of high (more than 38.5 ° C) temperature. The condition of these patients is carefully monitored for 48 hours after the administration of the drug, and in case of an increase in body temperature, they are prescribed for the entire period with an increased risk. hyperthermia take antipyretics.
  • Children with hypersensitivity reactions to the introduction of any vaccines in history. In addition, the doctor must be informed by parents of all cases. allergic reactionsfor family history of vaccines.
  • Disabled children hemocoagulation(eg, thrombocytopenia), since intramuscular injection in them is associated with a high risk of bleeding.

In patients who are being treated immunosuppressantsas well as in patients with impaired immunological reactivity Pentaxim vaccine response may be decreased.

If the patient has a history of development acute polyradiculitis or plexite in response to vaccination with drugs that include tetanus component, the physician must carefully weigh the benefits and potential risks of immunization with Pentaxim. Usually, in such cases, the completion of primary immunization is considered justified.

Side effects

The introduction of Pentaxim can cause side effects, both local and systemic.

The most frequent local reactions: redness, soreness (usually expressed short-term crying at rest or after light pressure of the skin in the injection area) and the appearance of a seal at the injection site (approximately 0.1-1% of cases, the diameter of the seal after vaccination exceeds 5 cm). The described side effects may develop within 48 hours after injection.

Systemic reactions to vaccination in a child are expressed as: hyperthermia (in 1-10% of cases the child's body temperature exceeds 38 ° C, in 0.1-1% of cases it is more than 39 ° C, in 0.01-0.1% of cases - more than 40 ° C), drowsiness, irritability, anorexia, sleep disturbances, vomiting, diarrhea, prolonged crying.

Extremely rare side effects of Pentaxim are skin rashes, hives, hypotension, febrile / afebrile seizures, anaphylactoid type reactions (shock, angioedema), hypotonic hyporeactive episode.

Sometimes the administration of a vaccine, in the composition of which the HIB component is present, is accompanied by cases of lower extremity edema (one or both at the same time, while the extremity on the administration side of the drug swells much more strongly).

Puffiness is noted mainly in the first few hours after the initial vaccination. In some cases, reactions of this type occur with hyperthermia, prolonged crying, soreness, discoloration of the skin (including the appearance of a bluish tint), are less common petechiaeredness, transient purpurarash

The described symptoms were not associated with any adverse events on the part of the respiratory system and the heart and disappeared on their own within 24 hours without any residual effects.

In very rare cases, the presence of a vaccine acellular pertussis component provoked pronounced reactions at the injection site (more than 5 cm in diameter), including tissue swelling, spreading over one or both joints at the same time.

These reactions occurred 24–72 hours after vaccination and were sometimes accompanied by localhyperthermia (at the injection site), soreness or increased sensitivity, as well as redness of the skin.

Side effects disappear within 3-5 days and do not require special treatment.

Presumably, the probability of their development depends on the number of injections. acellular pertussis component (that is, the risk of their occurrence increases significantly after the fourth and fifth doses of such a vaccine).

There is evidence that the introduction of other vaccines, which include tetanus toxoidaccompanied by neuritis of the brachial nerve and acute polyradiculitis.

You should inform your doctor about all adverse reactions to the introduction of Pentaxim (including those that are not listed in the instructions).

Pentaxim vaccine: instructions for use

The drug is intended for intramuscular administration. It is forbidden to inject the vaccine under the skin or intravenously.

Single dose - 0.5 ml. The injection is done in the middle third of the anterior-lateral surface of the thigh. Before you enter the suspension, you must make sure that the needle does not fall into the blood vessel.

If a package is used that comes with two separate sterile needles, before preparing the vaccine, the needle must be firmly fixed, turning it ¼ turn relative to the syringe.

To prepare the vaccine, you must first remove the plastic colored cap from the vial, then completely inject the suspension for intramuscular injection through a needle through a needle from a syringe into a vial with a lyophilized mass (vaccine for the prevention of HIB infections).

Without removing the syringe, the vial is shaken and wait until the lyophilized mass is completely dissolved (no more than 3 minutes). The resulting suspension is turbid and has a whitish tint. If the substance has changed color or there are impurities in it, it is prohibited to use it.

The finished vaccine is fully recruited into the same syringe and immediately administered to the child.

The instructions for Pentaxim indicate that the course of immunization with the drug involves the administration to the child of 3 doses of vaccine with an interval of 30-60 days. Vaccination begins when the infant reaches three months of age, revaccination is carried out by administering a single dose of the drug at the age of 18 months.

If the vaccination schedule is disturbed, the intervals between the second and third doses of the drug do not change, as well as the interval before the booster dose (it is 12 months).

If vaccination is started at the age from six months to a year, the second dose is administered 1.5 months after the first, and as the third dose, which is administered 1.5 months after the second, it is necessary to use a suspension for prevention tetanus, poliomyelitis, whooping cough and diphtheria, originally presented in the syringe (that is, it is not necessary to dilute the lyophilized mass in the vial).

For revaccination, in this case, the usual dose of Pentaxim is used, with dilution of the lyophilisate conjugated with tetanus toxoid polysaccharide HIB.

If the first vaccination is done to a child older than 12 months, then for each subsequent dose (including revaccinating) a suspension is used to prevent tetanus, poliomyelitis, whooping cough and diphtheriainitially presented in a syringe (without diluting the lyophilized mass in a vial (HIB)).

  • 1st vaccination - the complete drug is administered with the HIB component,
  • 2nd vaccination 1.5 months after the first vaccination - a full preparation with the HIB component is administered,
  • 3rd vaccination held until six months after the first vaccination - a full preparation with an HIB component is injected, if later - only a suspension from a syringe is injected, without diluting the lyophilisate (HIB),
  • revaccinationit is produced up to a year after the first vaccination - a full preparation with a HIB component is administered, after a year - only a suspension from a syringe is injected, without diluting the lyophilisate (HIB).

In all cases of violation of the schedule of immunization of the child, the actions of the doctor should be regulated by an appropriate vaccination calendar.


The physician should be informed about the introduction of any other medication to the child within the timeframe that coincides with the vaccination, as well as the 14 days preceding the vaccination.

If the child is undergoing treatment immunosuppressants, vaccination is recommended after its termination. This is because immunosuppressive therapymay reduce the response to the introduction of Pentaxim.

special instructions

To prevent possible adverse reactions (including hypersensitivity reactions), the doctor should evaluate the child’s health and history, check the history of his immediate relatives (including allergic) and the history of immunization, and clarify the incidence of side effects after previous immunization.

During vaccination, the doctor is obliged to have the tools and drugs that may be necessary in case of development allergic reaction.

Children taking immunosuppressants, vaccination should be postponed until the end of the course of treatment or remission of the disease. Parents of children with chronic immunodeficiencyvaccination is recommended despite the fact that the answer immune systemmay be weak.

One pharmacological group with Pentaxim vaccine includes drugs Bubo-kok, Bubo-m, DPT vaccine, DPT-M vaccine, DPT-Hep-B vaccine, Infanrix, Infanrix Hex, Tetraxim, Infanrix Penta.

DTP or Pentaxim - which is better?

In the composition of the drug Pentaxim are present tetanus and diphtheria toxoid antigens, cell wall components of Bordetella pertussis (pathogen whooping cough), 1-3 types of poliomyelitis inactivated virus and capsular polysaccharides HIB (hemophilus bacillus serotype b).

The main difference from Pentaxim DTP whole cell vaccine is a method for its production, due to which the vaccine is characterized by lower reactogenicity in comparison with its counterpart.

What is better - DTP or Pentax?

On this question doctor Komarovsky E.O. answers that the acellular pertussis component of the Pentaxim vaccine makes it easier for the infant to postpone the post-vaccination period, while the child is much less likely to suffer from pain at the injection site and fever.

Another "plus" of Pentaxim is also the fact that this vaccine makes it possible to immunize a child against 5 diseases in 4 injections.

Pentax or Infanrix - which is better?

What is better - Pentaxim or Infanrix? What is better Pentaxim or Infanrix Hex? Such questions worry almost all young parents who are confronted with vaccination for the first time.

Most often, doctors suggest vaccinating a child. DTPor Pentaxim or Infanrix. These drugs differ from each other in the number of components and the degree of their purification.

DPT vaccine allows you to develop a child's immunity to whooping cough, tetanus and diphtheria(it contains a suspension of dead microbes of Bordetella pertussis, as well as purified adsorbed on Al hydroxide tetanus and pertussis toxoids). DTP-Hep-B vaccine is a four-component drug that promotes the development of immunity towhooping cough, tetanus,diphtheria and hepatitis B.

Infanrix vaccine is a three-, four-, five-and six-component: three-component suspension Infanrix is ​​used for prevention diphtheria, whooping cough and tetanus, four-component suspension Infanrix IPV allows you to further develop the child’s immunity to poliomyelitis, the five-component Infanrix Penta is used for the prevention of these 3 diseases, poliomyelitis and hepatitis b, Infanrix Hex - for the prevention of 3 of these diseases, poliomyelitis, hepatitis B and HIB infections.

Unlike whole-cell vaccine DTPPentax and Infanrix- These are cell-free drugs that contain only fragments of disease antigens. Comparing reviews of parents whose children were immunized DTP and acellular vaccines, we can conclude that the latter are much better tolerated and cause fewer side effects.

To the question “What is better - Pentax or Infanrix? ”, Komarovsky E.O. answers that both vaccines are high-quality products with a high degree of purification of the components.

If we compare the tolerability of both drugs, then here wins Infanrix, insofar as pertussis component it is present in the maximum split form. This has an effect on the efficacy of vaccination, however, it makes it possible to repeatedly reduce not only the severity, but also the likelihood of adverse reactions.

Pentax or Tetraxim?

Preparations Tetraxim and Pentaxim are produced by one manufacturer. The only difference is the vaccine Tetraxim from Pentaximis the absence of a HIB component in it.

In cases where parents, in accordance with the individual immunization schedule, do not need to vaccinate the child against hemophilic infection, use of the vaccine Tetraxim allows not to overpay for the unused hemophilic component.

Pentaxim Reviews

Reviews of vaccination Pentaxim overwhelmingly positive. Reviews of doctors suggest that the drug is well tolerated by children, less frequently than whole-cell vaccine. DTP, causes side reactions, and allows you to vaccinate the child immediately from 5 diseases (that is, to reduce the number of injections).

Commenting on the rare negative reviews about Pentaxim, doctors emphasize that each child’s body is different, and it is impossible to predict its reaction to the vaccine. The key to the fact that for a child immunization will take place easily are the quality of the vaccine preparation, the state of health of the child and the conditions of vaccination.

Komarovsky E.O. he writes in his blog that healthy children who lead a normal life well tolerate vaccination, that is, children who walk enough, do not overeat, receive supplements in a timely manner (not too early), etc. When parents violate the basic principles of care, vaccination can be a blow to weakened immune system, and the child's body reacts violently to it.

For parents who vaccinated their children with Pentaxim vaccine, the main advantages of the drug are its efficacy, excellent tolerability (in most cases, the post-vaccination period is asymptomatic), the ability not to give extra shots, and in 4 injections to immunize simultaneously from 5 infections (for comparison, Infanrix, which is also well tolerated by children, allows to develop immunity only for 3 diseases).

The disadvantages of the drug, according to most mothers, are its high price and the frequent lack of vaccine in many pharmacies and vaccination centers.

Pentax price

The price of vaccine Pentaxim in pharmacies of Ukraine is 550-556 UAH. The price of vaccinations in Russian pharmacies is 1260 rubles.

You can buy Pentaxim in Moscow and other major cities at a regular pharmacy, or through an online pharmacy. However, in this case the conditions of transportation and storage of the drug may be violated (failure to comply with the cold chain is detrimental to the vaccine).

For this reason, in treatment rooms, to exclude the possibility of side effects, doctors refuse to vaccinate children with drugs brought by their parents if they are absent and advise them to contact commercial vaccination centers.

Composition, manufacturer and general characteristics of the vaccine Pentaxim

The vaccine Pentaxim is complex, that is, it contains not one, but several components, which makes it possible to vaccinate a child against five infections at once in one injection. The vaccine consists of two main parts - a syringe filled with a turbid suspension, and a vial with a dry lyophilisate. A suspension syringe contains components for vaccination against the following four infections:

  • Whooping cough,
  • Diphtheria,
  • Tetanus,
  • Polio.

A vial with lyophilisate contains only one component, intended for vaccination against infections caused by hemophilus bacillus type B (Haemophilus influenzae B). The combination of diseases caused by hemophilic B type bacillus is also called CIB infection.

Suspension contains diphtheria, tetanus and pertussis toxoids, as well as mortified poliomyelitis viruses of types 1, 2 and 3. All components of the vaccine are dead, and therefore cannot cause an infectious disease associated with inoculation. As auxiliary components, Pentaxim vaccine suspension contains aluminum hydroxide, Hanks medium, formaldehyde, acetic acid, and deionized water. The suspension is poured into a syringe in a volume of 0.5 ml, which is exactly one dose of vaccine. The lyophilisate in the vial contains 10 µg of particles of the membrane of a hemophilus bacillus type B, as well as sucrose and trometamol as auxiliary substances.

Pentaxim vaccine is produced by large pharmaceutical concern SANOFI PASTEUR, S.A. in France, and shipped to all European countries and the USA. In Western European countries, the vaccine is registered under the name Pentavac, and in all other parts of the world, including Russia, it is sold as Pentax.

Due to its multicomponent composition, one Pentaxim vaccine replaces three usual and childhood-familiar vaccines, such as DTP, against poliomyelitis and CIB infections. This means that for one injection of the Pentaxim vaccine, the child will be vaccinated against five infections. If you use the usual old, not combined vaccines, then in order to vaccinate a child against the same five infections, you will need to make three shots - DTP, Imovax Polio and against CIB infection.

Both the suspension syringe and the dry lyophilized vial included in Pentaxim vaccine each contain one dose of particles of various microbes, which are sufficient to produce only one vaccination for one child. That is, to put the child vaccinated with Pentaxim vaccine, you must give him the entire contents of the syringe and vial.

The division of the Pentaxim complex vaccine into a prepared suspension and a lyophilisate is not accidental, since it allows, if necessary, inoculating a child against only four infections - whooping cough, tetanus, diphtheria and polio, without the CIB component. The fact is that in order to fully form immunity against whooping cough, tetanus, diphtheria and poliomyelitis, a child under 5 years will need a total of four doses of vaccine, three of which must be administered at intervals of 1 to 3 months between them, and the fourth in a year after the last of the preceding three. The CIB component must be administered 1 to 3 times, depending on the age at which they began to vaccinate the child.

If the child began to be vaccinated according to the schedule, that is, at 3 months, then he will need to be administered one full dose of Pentaxim vaccine at 3, 4.5 and 6 months. And for revaccination at 18 months, only Pentaxim suspension containing components against tetanus, pertussis, diphtheria and polio will be needed, and the lyophilisate with the CIB component is no longer needed, since the child received all three doses against this infection. That is, the separation of the vaccine against CIB infection allows you to enter it only the necessary number of times, without exposing the child's body to excessive antigenic load.

Benefits of Pentaxim Vaccine

First, Pentaxim is a multivalent vaccine that contains components for vaccination against five infectious diseases at once. Until recently, Pentaxim was the only five-component vaccine registered in Russia and the CIS countries. However, recently Infanrix Penta and Infanrix Hex vaccines have been registered, which contain components for vaccination against five and six infections, respectively. That is, the first advantage of Pentaxim can be called precisely its multicomponent nature, which makes it possible to deliver a vaccination to the child against five infections in one injection.

Secondly, the advantage of Pentaxim over DTP and live polio vaccine is the acellular pertussis component and the dead poliomyelitis viruses in it, which give a lower antigenic load on the child’s body, are better tolerated and have no risk of developing vaccine-associated infections. Consider this advantage in more detail.

Thus, the DPT vaccine contains the pertussis component with cellular antigens in the form of weakened, but living bacteria. The presence of cellular antigens causes a violent response from the immune system, which is manifested by fever, allergic rashes and other severe reactions to the vaccine, which are familiar to many parents from their own experience or the stories of friends. It is the cellular pertussis component in the DTP vaccine that is the most reactive and causes severe tolerability of the vaccine. In the Pentaxim vaccine, the pertussis pertussis component is cell-free, that is, it does not carry a large number of antigens that cause violent and severe reactions in the child’s body, making the vaccine well tolerated.

In addition, weakened live bacteria in the DPT vaccine can trigger the development of whooping cough if the child’s immune system, due to its individual characteristics, could not completely suppress the pathogenic organism. Such an infection is called vaccine-associated pertussis, since the disease develops as a result of the introduction of pathogenic bacteria into the child’s body during its inoculation. The risk of vaccine-associated whooping cough with Pentaxim is zero, because it contains dead parts of bacteria, and not live and weakened, as in DTP.

Just as pertussis bacteria in DTP, weakened poliomyelitis viruses in a live vaccine that children drop into their mouths can cause vaccine-associated polio. This is a severe complication of the vaccine, observed in 1 - 4% of children. In the vaccine Pentaxim, the poliomyelitis viruses are dead, and therefore are not capable of causing a vaccine-associated infection. Thus, when using Pentaxim, the risk of vaccine-associated polio, like whooping cough, is zero. In addition, when using Pentaxim, the child should receive only four polio vaccinations - at 3, 4.5, 6, and 18 months, respectively. And when vaccinating with live polio vaccine, it will have to be administered five times - at 3, 4.5, 6, 18 and 20 months.

Immunity to all five infections, components of which are contained in the Pentaxim vaccine, occurs in 100% of children not suffering from severe congenital immunodeficiencies (for example, AIDS, hypogammaglobulinemia, etc.). The effectiveness of the vaccine is exactly the same as with the introduction of all five components separately in the form of different vaccinations.

Pentamax vaccine tolerability is very good, since severe reactions requiring medical attention are developed only in 0.6% of vaccinated children. Such good tolerance is characteristic of all four administered doses of the vaccine preparation. The safety of the vaccine has been proven not only for healthy children, but also for weakened, and often ill, and high-risk post-vaccination complications. Children who gave severe reactions to the introduction of DTP, in the overwhelming majority of cases, tolerated Pentaxim vaccination.

In addition, the antigenic load on the child's body when using the vaccine Pentaxim is ten times lower compared with the use of DTP + CIB infection + live polio. So, in the standard DTP contains 3000 different types of antigens of the bacteria whooping cough, and each of tetanus and diphtheria. Pentaxim contains only 2 antigens of whooping cough bacteria, 2 - CIB infections, one each of tetanus and diphtheria, and 15 - of the poliomyelitis virus. That is, with one dose of DTP vaccine, the child receives 3002 antigen, and Pentaxim - only 21. Thus, with the introduction of Pentaxim, the antigen load is less than a hundred times less than that when using DTP + CIB infection + live poliomyelitis. It is a small amount of antigens that makes Pentaxim vaccine safe, low-reactive, and well tolerated by children at any age and baseline.

Until what age can Pentaxim be vaccinated?

The Pentaxim vaccine contains a cell-free pertussis component that can be used to vaccinate a child or adult of any age. The same applies to the diphtheria, tetanus and polio components of the vaccine, which can be used for vaccinations at any age. But the CIB component of the vaccine Pentaxim is recommended for use only in children under 5 years of age.

Thus, the complete Pentaxim vaccine with the CIB component can be used to vaccinate children until they reach the age of 5 years, 11 months and 29 days inclusive. A part of the vaccine in the form of a finished suspension (components for whooping cough, diphtheria, tetanus and polio) without the CIB component (lyophilisate in a vial) can be used to vaccinate children and adults of any age who have not previously been vaccinated.

However, for revaccination of previously vaccinated children and adults of any age, Pentaxim vaccine in Russia and the CIS countries is not used, because for this purpose ADS-M, containing a lower dosage of antigens, is used. If a child or an adult has received all 4 doses of Pentaxim vaccine, which are necessary for the formation of full immunity to infections, then this drug is not allowed to be used according to the regulations of the Ministry of Health of the Russian Federation. Instead of Pentaxim, for all subsequent revaccinations, it is necessary to use the ADS-M vaccine. But in the countries of Western Europe and the USA, Pentaxim vaccine without CIB component is also used for revaccination of adults and children at any age. Therefore, theoretically, Pentaxim without CIB component can be used at any age.

What does the CIB component of Pentaxim protect against?

The CIB component of the vaccine Pentaxim protects a child from severe infections caused by hemophilus bacillus type B. The CIB infection in children under 5 years of age is very difficult and difficult to treat because the pathogen is resistant to many well-known antibiotics. Thus, according to world data, it is the type B hemophilus bacillus in children under 5 years old that provokes about half of severe meningitis, 80% of epiglottitis and 20-25% of pneumonia and sepsis. Upon reaching the age of five, the hemophilus bacillus becomes low-risk for the child, since the immune system becomes mature and effectively suppresses the pathogenic bacterium, preventing it from provoking severe bacterial infections of the brain, lungs and epiglottis. But up to five years, the child easily becomes a victim of aggressive bacteria. The CIB component of the vaccine Pentaxim protects the child from hemophilic bacilli, which can cause extremely dangerous diseases, often fatal.

However, this does not mean that after vaccination, the child will be protected from any meningitis, pneumonia or sepsis, since they can be caused by various pathogenic microbes, and not just type B hemophilus bacillus. Remember that Pentaxim protects only from hemophilic bacilli, but does not form immunity to other pathogenic bacteria that can also cause sepsis, meningitis, epiglottitis, etc. However, infections triggered by other bacteria in children younger than 5 years old are much easier and respond well to therapy, and therefore do not pose such a danger as diseases associated with a hemophilic rod.

A vaccine against CIB infection is recommended for children under 5 years old, since it is up to this age that their body is especially vulnerable to a hemophilus rod. Immunity from CIB infection after vaccination persists for five years, and since this pathogenic bacterium is not so terrible to a child older than 5 years of age, it is not necessary to carry out revaccination.

In addition to protection against CIB infection, this component of the vaccine Pentaxim reduces the number and severity of SARS in a child, since it has a stimulating effect on the cellular immunity of the upper respiratory tract. Therefore, if the vaccine against CIB infection was not given to a child in the first year of life, it is recommended to do so before entering a preschool institution.

General rules for vaccination with Pentaxim

The vaccine Pentaxim is administered strictly intramuscularly. In children under one year, it is optimal to introduce the drug in the middle part of the outer surface of the thigh, and at an older age - in the upper part of the shoulder, where the muscle is clearly visible. Pentaxim is strictly forbidden to enter into the buttock, since in this part of the body, children and adults have a rather thick layer of subcutaneous fat, into which the entire dose of vaccination may fall. If the vaccine gets into the subcutaneous fat layer, then it will be useless, because it does not absorb into the bloodstream in the required amount. In addition, a shot in the buttock can injure large nerves, which is fraught with serious complications. The general rules for administering Pentaxim vaccine are shown in Figure 1.

Picture 1 - Technique of vaccination Pentaxim.

The vaccine is administered according to the following established regulations. First, you should take out the syringe filled with the suspension, and shake it several times to mix the contents well. Then, a needle is inserted into the syringe. If the child does not need the Pentimax CIB component, then after these preparatory actions, only the suspension in the syringe is injected.

If the child needs an injection with the CIB component of the Pentaxim vaccine, then after fixing the needle on the syringe, a bottle of lyophilisate is available in the kit. A colored cap is removed from the bottle, after which the entire volume of the suspension is discharged directly from the syringe. The bottle is gently shaken with rotational movements, dissolving the entire lyophilisate. Dissolve within a maximum of three minutes. The finished product is cloudy, painted in a whitish color. If flakes or any particles appear in the vaccine after the lyophilisate is dissolved, or the color has changed, then such a preparation cannot be used. The finished solution must be immediately administered intramuscularly, not leaving it stored even for a short period of time.

How to prepare a child before vaccination

Перед прививкой ребенка желательно подготовить, чтобы он легче перенес манипуляцию. Для этого необходимо утром в день прививки не кормить ребенка, а только хорошо его напоить. Также следует обязательно проследить, чтобы ребенок покакал накануне прививки или утром в день вакцинации. Если малыш перед прививкой 2 – 3 дня не какал, то прививку следует отложить до того момента, когда произойдет дефекация. If it is not possible to postpone the vaccine, then the child should take care of the bowel movement in advance, for example, on the day before the vaccination 2-3 times after eating, give him to drink lactulose syrup, which has a mild laxative effect.

Then the child should be dressed for the weather so that he does not sweat until you reach the clinic. Directly in the clinic, you must undress the child and give him to drink water. And if he is still sweating, then you need to sit on the bench and allow the child to cool. Only after the child has cooled and stop sweating, you can enter the vaccination room and administer the vaccine. After vaccination, you can walk on the street, if the child does not mind, then come home and not feed the baby for as long as possible, but give only plenty of drink. Feed the child only when he asks for it himself. And he needs to be given a dietary dish, for example, low-fat soup, liquid porridge on water, etc. You can not give nourishing, sweet, etc., because it will worsen the tolerability of vaccinations.

Within 2 - 3 days after vaccination should monitor the temperature of the child. If it starts to rise, then it is recommended to bring the temperature down, since it does not bear any positive effect, it only worsens the condition of the baby and unnerves the parents. The temperature is brought down only with preparations containing paracetamol, ibuprofen or nimesulide. In case of their ineffectiveness, it is necessary to consult a doctor.

Pentaxim Administration Rules for a Child Suffering an Acute Disease

In case of any acute illness or exacerbation of chronic, it is necessary to postpone vaccination until full recovery or the onset of a period of remission. Doctors recommend vaccination no earlier than 2-4 weeks after recovery or the beginning of the remission period.

If a child has had an acute respiratory viral infection or an acute intestinal infection, then Pentaxim can be vaccinated immediately after normalization of body temperature, not paying attention to residual catarrhal phenomena such as a runny nose, cough, unstable stool, etc. Children who have had meningitis or other diseases of the nervous system should not be vaccinated with Pentaxim for at least six months after recovery. Often sick children do an inoculation in 5 - 10 days after an ARVI, not paying attention to the residual catarrhal phenomena.

The rules for administering Pentaxim to a child suffering from allergies

If the child suffers from periodic spasms of the respiratory tract, Pentaxim should be administered no earlier than 2-4 weeks after the elimination of the next episode. These children should be vaccinated against the background of parallel use of hormonal bronchodilators (as a spray) and antihistamines (orally in the form of tablets). Bronchodilators and antihistamines begin to apply 1 to 2 days before vaccination and continue for another 3-4 days after vaccination. After that, hormonal bronchodilators are canceled, and antihistamines continue to be taken according to the standard regimen recommended by the attending physician.

Pentaxim vaccination schedule

A full course of vaccination, after which the child develops immunity to tetanus, diphtheria, whooping cough, poliomyelitis and CIB infection, consists of three doses of Pentaxim, which are administered with an interval of 1 - 3 months between them. According to the schedule of the national immunization schedule of the Russian Federation, Pentaxim is administered to children at 3, 4.5 and 6 months. At this, vaccination against CIB, polio, tetanus, diphtheria and pertussis is considered complete, since all the diseases listed after three doses of Pentaxim are given a persistent immunity.

One year after the third vaccination dose, that is, at 18 months (1.5 years), the child is boosted, which consists in administering another dose of Pentaxim vaccine. This revaccination is necessary to maintain previously developed immunity to infections. Thus, the full course of vaccinations for Pentaxim in children according to the schedule of the national calendar is as follows - at 3, 4.5, 6 and 18 months. This course, consisting of four vaccinations, allows the child to form immunity to five infections (CIB infection, polio, tetanus, diphtheria and whooping cough), which will last for 5 years. The next revaccination against diphtheria, whooping cough, tetanus and poliomyelitis will need to be done in five years, that is, at 6 - 7 years of age.

If a child’s vaccination does not start according to the national calendar’s schedule, that is, not three months, but later, then it is carried out according to the following scheme 1 - 2 - 2 - 12. This means that the first vaccination is administered, then two months later the second one is given, 2 months - the third. And 12 months after the third vaccination, the fourth dose of Pentaxim vaccine is administered. On this, the child’s vaccination against polio, whooping cough, tetanus, diphtheria and CIB infection is considered complete, and the acquired immunity will remain for five years. Therefore, revaccination will need to be carried out only five years after the administration of the fourth dose of Pentaxim.

When Pentaxim vaccinates a child of any age, the contents of the syringe (ready-made suspension) with pertussis, tetanus, diphtheria and poliomyelitis components in all four vaccinations from the cycle are always fully injected. And the CIB vaccine component (lyophilized vial) is administered 4, 3, or 1 times, depending on the age at which the baby was vaccinated with Pentaxim. The rules for introducing the CIB component Pentaxim, depending on the age at which the child starts to be vaccinated, are shown in the table.

Immunization Medication

Vaccine "Pentax" was created thanks to the development of scientists and refers to the universal immunobiological preparations. The manufacturer of the drug is France, but sometimes there are other countries. The tool is intended for the prevention of childhood infections, which are caused by the bacillus Leffler, gram-positive bacillus and Poliovirus hominis.

The DPT vaccine, popular in the old days, is gradually being replaced by the Pentaxim vaccine. Reviews of parents and doctors show that this drug is much easier for children to carry and rarely provokes complications such as fever, swelling and soreness at the injection site. This effect is due to the absence of membranes of bacterial lipopolysaccharides. It is these substances most often serve as a source of side effects.

Distinctive features

Increasingly, parents choose to protect their children from diseases "Pentax". The composition of the vaccine and reviews contribute to the adoption of such a decision. The name is fully consistent with its purpose and its constituent substances. The solution is designed to prevent the development of five different diseases, from which many children had previously died.

The drug itself is supplied in disposable syringes, which relies vial, which contains lyophilisate. Experts explain why this separation is necessary. If the baby is absolutely healthy, then simultaneous vaccination against five diseases is possible at once. But often little patients have any irregularities, and then the schedule of vaccinations may differ.

Most often, a first injection is given only against four pathologies, excluding a hemophilic infection. Only after the establishment of a strong immunity and examination by doctors further vaccination is carried out. This practice is designed to alleviate the condition of children after vaccination and prevent serious complications from developing.

Drug composition

Fully studied and verified composition has the vaccine "Pentax". Reviews of doctors suggest that the vaccine protects against the stated diseases, but it does not cause serious consequences, as could be the case with the introduction of standard DTP.

The drug is supplied in a syringe and a small bottle. The composition of the liquid from the syringe is as follows:

  • filamentous hemagglutinin,
  • aluminum hydroxide,
  • whooping cough anotoxin
  • formaldehyde,
  • diphtheria toxoid,
  • tetanus toxoid,
  • poliomyelitis virus of three types,
  • Hanks Wednesday
  • phenoxyethanol
  • water for injections.

The bottle contains a lyophilisate, which consists of:

  • tetanus toxoid,
  • polysaccharide,
  • sucrose,
  • trometamol.

Syringe and vial contain only one dose. The drug is intended for administration to one patient.

The feasibility of vaccination

Increasingly popular gains "Pentax". What diseases and vaccines are interested in by health-care parents of their children? Now, disputes about the feasibility of vaccinations do not abate, and many refuse to take such measures. However, when making a final decision, it is worth remembering that before vaccines were invented, many children died from diseases that could be defeated with their help.

The main concern of moms and dads is complications after drug administration. Experts confirm that this was possible after the introduction of outdated DPT. The French vaccine "Pentax" has collected only positive reviews, so there is no reason to refuse vaccination. Kids after it feel good, the temperature does not rise or reaches insignificant parameters, and the injection site does not swell.

What helps?

Thanks to the development of modern pharmacology, many deadly diseases are taken under complete control. One of the means of guarding the health of the youngest patients is Pentaxim. From which diseases the vaccine and the reviews about it are the questions that every conscious parent examines before going to the clinic. The drug is designed to protect and create a powerful preventive barrier against the following diseases:

  • diphtheria,
  • tetanus,
  • whooping cough,
  • polio,
  • infections caused by hemophilus wand.

The usual vaccination calendar involves the introduction of "Pentaxin" in the third month of the infant's life. However, if, for health reasons, a child has not received a single vaccine before the year, it is this imported vaccine that will be recommended by the pediatrician as the safest, but effective.

The complex is also used subject to the availability of vaccinations, but not fully conducted a course against polio.

Opinion pediatricians

The most popular vaccine is Pentaxim. Reviews of doctors based on laboratory research, pediatric practice and the merits of the drug. To understand why this vaccine is safe, effective and necessary, experts argue the following:

  • The drug can reduce the number of vaccinations. If earlier the kid and his parents had to endure three different injections - against polio, rotavirus and DTP, now you can take root immediately from five diseases at the same time.
  • The child is practically not observed or they are minimized negative reactions. If earlier the risk of developing associated whooping cough was large enough, now it is practically absent. This is made possible by the use of a non-cellular active component.
  • Post-vaccination polio often developed with the introduction of a live vaccine, which included weakened strains of the disease. Now this risk is completely excluded, because the vaccine consists of an inactivated (dead) virus.
  • Only completely healthy children without neurological and other pathologies were shown to have DPT vaccine. "Pentax", reviews of this can be used for vaccination of children with HIV, with a history of febrile seizures and any neurological diseases. In addition, this drug is indicated in the presence of intolerance and hypersensitivity to DTP substances.

Unfortunately, such a vaccine is not always available in the clinic. But doctors advise her parents to get those babies who have health problems.

When to be vaccinated

The approved use schedule has been developed for the Pentaxim vaccine. Instructions and reviews will always help you navigate the need to visit a doctor. The specialist will explain that with the primary scheme it is necessary to put three injections with intervals between them in 45 days. In a year, revaccination will be required. In the feedback of experts focuses attention that such a scheme will reliably protect the baby from insidious diseases.

It is important to administer Pentaxim vaccine on time. Instructions and feedback from parents confirm that only following the schedule will help avoid infection. For this, the Russian Federation has an established schedule.

  • The first injection is given to an infant who is three months old.
  • the second - exactly 45 days,
  • the third vaccination accounts for six months of the baby’s life,
  • In a year and six months it is imperative that revaccination be performed.

Such a tablet can always be taken from the pediatrician and strictly follow it. However, each child develops in his own way, he may experience various deviations. In this case, the doctor will develop an individual vaccination scheme. At the same time, not only the timing of major vaccinations, but also the time of revaccination are shifted. If the baby is already more than a year old and he has not received any dose, then at the first intake all five components are pricked, without separating them. Further, the Hip-component is removed and adhered to the above recommended scheme.

How is the procedure?

Anyone who decides to give their children the Pentaxim vaccine, instructions for use and feedback should be carefully studied. Of course, the doctor must conduct a preliminary examination of the child. At the same time, the temperature is measured, the throat is checked, the lungs and heart are tapped, the skin is examined for inflammation. But only the mother can know for sure about the state of health of her child and tell the pediatrician about her doubts.

Earlier, doctors advised to prepare a baby and drink antihistamines before vaccination. After the procedure, it is necessary to give the child antipyretic and refuse to walk. Vaccine "Pentax", reviews confirm this, does not require such careful preparations. But medical examination and the exclusion of diseases will help prevent possible negative consequences.

The components of the drug are designed to develop strong immunity against five infections. The nurse makes an injection using an individual syringe containing the vaccine. Traditionally, they put it in the leg of the baby in the hip area. The procedure itself is certainly unpleasant, but it does not differ in particular pain. Mothers say that babies quickly calm down, and the absence of swelling and high temperature makes vaccination fairly easy.

Vaccine features

Increasingly, doctors and parents prefer imported vaccine. Reviews about DTP and Pentaxime are quite different. If the first generation vaccine was often hard tolerated by children and required a larger number of shots, then the French vaccine does not cause side effects and can prevent the development of five diseases at once.

However, the drug in its entirety (in a syringe and vial) is used at a time only up to six months. If this time is missed, then vaccination is carried out without the use of pertussis toxoid. Also, experts recommend using another tool, for example, "Tetraxin", if revaccination requires the introduction of the drug without the Hip-component.

Preparation for the procedure

Usually the vaccine is well tolerated by the kids. If the child is healthy, no preparatory procedures will be required. However, doctors rekomenduyut still hold a series of activities to completely eliminate all sorts of risks and complications:

  • Before the procedure, it is better not to feed the child a lot.
  • You must make sure that the baby had a stool on the day of vaccination. Allowed the day before. With regular constipation, laxative should be given.
  • If the child is prone to allergic reactions, then within 2-3 days it is necessary to start giving antihistamines recommended by the doctor.
  • Do not use new medicines, food and hygiene products before vaccination.

Vaccine "Pentax": reviews moms

Imported drug is increasingly used. Many conscious parents buy their own vaccine if they cannot offer it at the local clinic. The feedback indicates that the drug has no side effects, like DTP. The baby does not have a fever, does not blush and does not inflame the leg at the injection site. In addition, the preparation procedures are not so complicated and are required only in some categories of patients.

However, sometimes there are negative responses. Moms record local reactions in the form of pain in the area of ​​administration of the drug. The baby is capricious and anxious. Among the main claims made by parents are:

  • hip swelling,
  • anxiety and cry baby
  • redness of the skin.

It is worth noting that the temperature rise after the procedure occurs extremely rarely, and moms do not complain about it. After vaccination, there is virtually no risk of acute development of those diseases from which the child was vaccinated.

Possibility of replacement

In terms of its effectiveness and safety, it is not inferior to the French development of Infanrix. The composition also contains cell-free components, so the risk of complications is reduced to zero. The vaccine is developed against whooping cough, tetanus and diphtheria, which brings it closer to standard DTP. But there are differences. Препарат шестикомпонентный и, помимо перечисленных штампов, включает еще компоненты таких вирусов, как:

Болезненность, покраснение и припухлость в месте введения этой вакцина возникает редко. Иногда родители интересуются, что лучше - «Инфанрикс» или вакцина «Пентаксим». Отзывы врачей показывают, что существенных отличий такие препараты не имеют. Однако «Инфанрикс» не рекомендован детям, которые имеют непереносимость и повышенную чувствительность к антибиотикам, в связи с включенным в состав препарата неомицином.


Of course, only his legal representative can make the decision to vaccinate his offspring. Many refuse vaccinations, considering them harmful to health, undermining immunity and causing serious consequences. However, this decision is fundamentally wrong.

If vaccinations of the old generation and domestic production cause distrust, then it is worth using foreign analogues. As the testimonials of mummies and the practice of pediatricians show, the tolerability of such drugs is excellent, and the efficiency is top notch. Anyone who cares about the health of their baby, must necessarily make all the necessary vaccinations.

Vaccine "Pentax": reviews, composition, instructions for use on

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The composition of the vaccine, its detailed characteristics and the leading manufacturer

Pentaxim is a comprehensive set of components from several formidable infections that the fragile organism may face. It is produced by the world-famous concern in France “Sanofi Pasteur, S.A.” The products are supplied to many countries in the near and far abroad. It is one of the few five-component vaccinations registered in the Russian Federation.

Using this drug, the baby receives prophylaxis not from single diseases, as in ordinary vaccinations, but from five pathogens. The kit contains two elements: a syringe with a suspension and a bottle with the contents of the lyophilisate. The composition of the suspension includes components from four pathogens:

  • diphtheria sticks,
  • polio virus,
  • pertussis pathogen,
  • Clostridium tetanus.

The bottle also contains only one ingredient: the introduction of a vaccine with it protects against a number of infectious lesions that are caused by a hemophilic bacillus (it is also called HIB).

The liquid base contains three types of toxoids - diphtheria, pertussis, and tetanus. They do not contain pathogens, but only their neutralized toxins, they induce the body to develop an immune response. It also includes the "dead" polio virus, it does not cause the disease. Thus, the drug does not include live weakened microorganisms and it is completely safe in terms of infection.

The suspension contains additional elements: Hank's medium, non-ionized water, acetic acid, formaldehyde, aluminum hydroxide. Ampoule with dry lyophilisate contains 10 micrograms of Haemophilus influenzae membrane particles and additional substances: trometamol and sucrose. All ingredients in the amount of 0.5 milliliters - this is 1 dose of medication.

The right choice: why is Pentaxim vaccine better?

First, it is the drug of choice, which allows the child to produce fewer invasive procedures. The vaccine Pentaxim is multicomponent: by spending only one injection, the effect of immune protection is immediately achieved from five pathogens.

Secondly, the separation of the CIB component is very convenient to use, and here's why. Performing the first vaccination at the age of 3 months, all components are introduced, including hemophilic lyophilisate. Injections in full dosage are repeated in 4.5 months and in half a year.

Further, in one and a half years old, the revaccination period will do. The introduction of the vaccine from Haemophilus influenzae is not carried out, since the protection has already been formed, the baby received the necessary doses at 3, then at 4 and 5 months of age. Therefore, the dry drug is not used, performed vaccination against four pathogens contained in the syringe reservoir. In other words, the selectivity of vaccination has the advantage: it can be used without overloading the baby's body with antigens.

Pentaxi is significantly inferior to the administration of DPT vaccine. It provides protection only against three pathogens: diphtheria, tetanus and pertussis sticks. That is, there are no polio antigens. Moreover, in the Russian version there are live sticks provoking whooping cough disease. With a weak immune system, the baby has the opportunity to provoke a vaccine-associated disease. In the Pentaxim preparation, this pertussis is cell-free, that is, it is presented in the form of toxoid. This form eliminates the risk of developing the disease.

The presence of cellular structures in DTP causes a pronounced reaction in the child in the form of increased body temperature, skin rashes, and even common phenomena involving other organs and systems.

Just as in the example of DTP, droplets of polio vaccine contain a live culture, which is also not always safe. On the example of Pentaxim, when a vaccine is introduced, it contains a dead virus, and this in no way diminishes the effectiveness of its action, preventing the risk of disease. Its components do not cause sensitization and a stormy negative response from the body that accompany DPT vaccination. Pentaxim is safe, effective, while the load of antigens is much lower than if it were inoculated by conventional means (DTP, polio, Haemophilus influenzae). The frequency of the vaccine is also reduced: the baby receives only 4 vaccinations instead of five according to the usual schemes (at the age of three, four, five months, six months, one and a half, and one year 8 months). Thus, its use is recommended for impaired children, with the permission of a doctor, for babies with comorbidities.

How old is Pentaxim vaccine?

Focusing on the vaccination schedule approved on the territory of Russia, the administration of the Pentaxim vaccine begins at the age of three months. This is followed by injections at 4.5 and 6 months, followed by revaccination at 1 year and 6 months, and at this age, CIB is not indicated.

With the pertussis component in the cell-free form, Pentaxim is not dangerous for both children and adults for immunization. However, the substance against Haemophilus influenzae contained in the lyophilisate of the vial is used exclusively for children under five to six years old.

So, a complete set of medication is allowed to use only up to six years. As a means for revaccination, only the liquid portion contained in the syringe is taken. The medicine without the HIB element is injected to re-protect the already vaccinated children and immunize adults.

Important! Pentaxim vaccine without a lyophilized element from a hemophilic microorganism is used in all categories starting from 3 months of age.

CIB component: which diseases it warns and why it is so important

Hemophilic bacterium threatens with diseases involving a number of vital organs in young children under five. Their defense system is not yet able to cope with the infection, which can have fatal consequences.

After vaccination, the pathogen provokes the development of pathology, affecting the following organs and ending with severe outcomes:

  • brain (meningitis),
  • lungs with the development of pneumonia, abscesses, etc.,
  • general damage to the blood and organs - sepsis.

After this age, the immune response of the baby is already formed so that the microorganism does not pose a particular danger and the need for immunization disappears.

Pentaxim: step by step instructions and vaccination rules

Vaccination is carried out in a procedural or vaccination room polyclinic specially trained nurse. It is pricked strictly in the muscle area, for small children up to one year old - in the mid-outer third of the thigh, and for older children - in the deltoid muscle of the shoulder.

Attention! Enter into the area of ​​the buttocks is prohibited, as this section contains a large amount of fatty tissue, and getting into this layer can lead to the uselessness of the procedure and even harm. Injection can damage closely located vessels and nerves, poor absorption in adipose tissue will not give the desired result.

Injection Technique:

Note. Before the procedure, check the expiration date!

  • In medical conditions, in strict compliance with sterility, get a syringe with liquid contents, shake it vigorously, and insert the needle.
  • If the HIB vaccination is not provided, then the injection is made without taking material from the vial.
  • In the case of a five-component immunization with Pentaxim vaccine, you should get a bottle of powder, remove the cap. After puncture of the soft top of the ampoule, the liquid is completely discharged from the syringe, and the needle is not removed or removed from the syringe. Shake the bottle gently for about three minutes to achieve complete dissolution.
  • The resulting fluid is injected into the muscle, clearly perpendicular to the surface.

Attention! The remains of the vaccine should not be stored! Ready solution of a dull-whitish shade without inclusions. If there is flakes or sediment of a different color, the use of such a drug is prohibited!

Baby preparation

First of all, the baby must be healthy and not have restrictions on the procedure. The mode of the day and food should be normal. Follow the baby, he should be less naughty, because stress can adversely affect the state.

Ensure that the baby's intestines are emptied on time, as constipation adversely affects the well-being and can lead to undesirable toxic effects. If it is impossible to timely defecate, give the child lactulose in syrup on the eve of the injection.

Do not feed your baby before vaccination, but give plenty of drink.

Overheating is not allowed: if the baby is very warmly dressed, then going into the treatment room, he will be sweaty. This is also not allowed to allow.

Immediately after the vaccine, it is strongly not recommended to feed, it must be done not earlier than 1-2 hours later. Meals should be dietary, not containing fat and pickles. It is advisable to limit sweets.

Within two to three days after vaccination, there is sometimes a slight increase in body temperature, so the reaction of the child should be monitored. In the case of subfebrile, give antipyretic medication recommended by the doctor.

The kid had an acute infection: what to do?

It all depends on the disease and its severity. If it is the height of a banal infection with an increase in body temperature, in this case the vaccination is carried out with the permission of the attending physician. Lead the child to the procedure will have no earlier than two weeks from reducing the symptoms of the disease. The recovery period sometimes lasts up to 30 days.

If a respiratory infection or intestinal lesion is present, Pentaxim should be vaccinated after stool has been restored and intoxication symptoms (temperature, weakness) have been eliminated. At the same time, catarrhal phenomena in residual form are not of great importance.

Babies who have had meningitis and other serious problems with the nervous system are vaccinated no earlier than six months later, subject to clinical recovery.

How to vaccinate a baby if he is allergic

It is necessary to plan vaccinations at the time of relieving allergy symptoms, using antihistamine therapy prescribed by a doctor.

Attention! Children suffering from various forms of allergic reactions, as well as asthmatic attacks and various spasms of the respiratory tract of an allergic nature, must be observed in a children's allergist.

Such patients usually suffer from allergies in the form of skin rashes, bronchospasms with coughing episodes, difficulty in breathing, or even suffocation. Antiallergic measures are held 1 - 2 days before vaccination and 3-4 after it.

During the period of therapy and after the injection, they are prescribed antiallergic drugs in injections, tablets, ointments. In the case of an asthmatic component - bronchodilators, sometimes - hormonal agents. Avoid vaccinations during the period of active flowering, as this may aggravate the condition of the child.

Sequence of procedures for the schedule

Pentaxim vaccine is administered three times.

Initial vaccinations form resistance to the disease in all 5 types of pathologies. They are entered three times in 1-2 and 3 months from one another.

Thus, a full dosage with a component from Haemophilus influenzae is pricked by a 3-month-old baby, with a repeat of 4.5 months and half a year. According to the regulatory documents of the Russian Federation, immunization against diphtheria, tetanus, poliomyelitis, whooping cough sticks, a hemophilic pathogen is completed at this stage.

The second stage - revaccination

The following procedures are allowed one year after the last vaccination.

Note. Pentaxim vaccine can be used even if previous vaccinations have been made with another medicine. However, with subsequent revaccinations, it is already prohibited to use it, since the content of antigens for that age already exceeds the permissible rate. Usually then apply ADS-M.

Is it possible to combine with other vaccines

In Russia, all vaccines are replaceable.

Important! Vaccination is carried out under strict supervision of a pediatrician, all manipulations - only after a thorough examination.

Pentaxim contains an element of poliomyelitis, it is absent in Infanrix. If in the procedures carried out earlier, the child received an inactivated vaccine, now this medicine will perfectly replace it, receiving protection from three more terrible ailments.

Possible adverse reactions to the vaccine

Since in the process of grafting an alien agent is introduced into the body, one or another reaction of the body can be detected in the process of producing antibodies. Each child is individual, therefore, the response is different for everyone.

Side effects may be local in nature, which is quite acceptable, or be common.

  • redness at the vaccine injection site, slight soreness,
  • seal around it,
  • slight puffiness.

Usually such phenomena do not require additional treatment and disappear on their own within a week. Requires dynamic observation and proper care.

Manifestations of a general nature can be dangerous, so if you experience negative symptoms, immediately contact your doctor or call an Ambulance.

These include:

  • fever,
  • refusal to eat
  • digestive disorders,
  • swelling, rash,
  • convulsive syndrome
  • anaphylaxis.

The last group of complications is rare, with the exception of subfebrile temperature. You can cope with this by giving the child antipyretic drugs.

Parent feedback on the vaccine

Opinions are different, but most of them are positive. Most mothers experienced the use of Pentaxim, were satisfied with good tolerability and minimal reactions from the body of the child. The only negative side of the problem is that the vaccine is paid.

In a minority of children, reactions to the administration, poor tolerance, were observed. Parents notified pediatrists about the troubles. This was due to the burdened allergic history and comorbidities on the part of the organs.

The choice between Pentaxim and Infanrix

According to the observations, there are fewer side effects from Infanrix, it is more easily tolerated. However, the drug gives protection only against three types of infections. Therefore, in order for the baby to be protected from all ills, more injections will be required. This option is more invasive.

Applying Pentaxim, immediately achieved the effect against five very dangerous pathogens, which is less traumatic. The choice is for parents.

New vaccines: Infanrix, Infanrix Hex, Pentaxim. What's better?

The benefits of the Infanrix vaccine have been indicated above. It will be appropriate to repeat that it protects against three pathogens: diphtheria, tetanus, whooping cough. It is an analogue of DTP. However, in our preparation the component is represented by fragments of the cell wall, and in Infanrix it is cell-free, that is, it works at the molecular level. This increases vaccine safety and tolerability.

Pentaxim protects against five infections. Both drugs are manufactured abroad, they are of very high quality. The main difference between them - in the composition of the components. The first vaccine against three infections, the second - from five. Both that, and another provide high-quality immunity.

Increasingly enters into practice Infanrix called Hex. It includes six components: those that are in Pentaxim, and, very importantly, against hepatitis B. The medicament is easy to use, thanks to it, the number of injections can be significantly reduced.

All three medications are of decent quality and interchangeable. The use of one or another of its type depends on the appropriateness at each particular stage of vaccination according to the national vaccination schedule. In this case, the pediatrician should competently draw up a sequence of vaccinations with modern means.

Why is DPT inferior to Pentaxim?

Domestic vaccine contains a cellular composition of whooping cough, which sometimes results in severe post-vaccination allergies. Pentaxim is well tolerated and has no side effects.

The use of DTP may not produce sufficient immunity in a child against whooping cough, as a result of which it may deteriorate.

Пентаксим безопаснее, эффективнее, проще.

Аналогичные вакцины отечественного производства дети получают бесплатно. Учьтите все «за» и «против». Возможно, цена прививки и здоровье малыша – это небольшая стоимость по сравнению с тем, что может произойти.

Цена упаковки препарата, равная одной дозе, в Российской Федерации находится в пределах 1200-1400 рублей. В медицинских центрах достигает 2700 рублей.

Где приобрести

Продажей вакцин занимаются аптеки и специализированные центры вакцин. It should only be clarified that in the pharmacy to buy Pentaxim is much cheaper.

If you have to transport the drug in the summer and it is hot on the street, you should take a cooler bag with you or, for lack thereof, a bubble with ice in which you place the vaccine while you are moving.

Analogs Pentaxim

Coincides according to indications

Price from 0 rubles. Analogue cheaper by 0 rubles

Coincides according to indications

Price from 1210 rubles. Analog is more expensive for 1210 rubles

Instructions for use to Pentax

Vaccine for the prevention of diphtheria and tetanus adsorbed, acellular pertussis, inactivated poliomyelitis, infections caused by Haemophilusinfluenzae type b conjugated. Registration Certificate No. LSR-005121 / 08-010708 of July 1, 2008


Lyophilisate for the preparation of suspensions for intramuscular administration of 1 dose, complete with suspension for intramuscular administration of 0.5 ml.


1. Vaccine for the prevention of diphtheria and tetanus adsorbed, acellular pertussis, poliomyelitis inactivated (suspension for intramuscular administration).

One dose of vaccine (0.5 ml) contains:

Active substances: diphtheria toxoid ... ≥ 30 IU, tetanus toxoid ... ≥ 40 IU, pertussis toxoid ... 25 mcg, Hemagglutinin filamentous ... 25 mkg, Type 1 poliomyelitis virus inactivated ..........40 units of antigen D, polio virus 2-th type inactivated ... 8 units of D antigen, poliomyelitis virus type 3 inactivated ... 32 units of D antigen, Excipients:
aluminum hydroxide 0.3 mg, Hank's medium 199 * 0.05 ml, formaldehyde 12.5 μg, phenoxyethanol 2.5 μl, water for injection up to 0.5 ml, acetic acid or sodium hydroxide - up to pH 6.8 - 7 3

*: does not contain phenol red

2. Vaccine for the prevention of infection caused by Haemophilus influenzae type of bconjugated (lyophilisate for suspension for intramuscular administration)

One dose of the lyophilisate contains:

Active ingredient: polysaccharide Haemophilusinfluenzae type b,
conjugated with tetanus toxoid ... 10 μg.

Excipients: sucrose 42.5 mg, trometamol 0.6 mg,


Vaccine for the prevention of diphtheria and tetanus adsorbed, acellular pertussis, poliomyelitis inactivated (suspension for intramuscular administration):

Whitish muddy suspension. Vaccine for the prevention of infections caused by Haemophilusinfluenzae type of bconjugated (lyophilisate for preparing suspension for intramuscular administration):

White homogeneous lyophilisate.APPOINTMENT

Prevention of diphtheria, tetanus, whooping cough, polio
and invasive infection caused Haemophilusinfluenzae type b
(meningitis, septicemia, etc.) in children from 3 months of age.


Progressive encephalopathy, with or without convulsions. Encephalopathy developed within 7 days after the administration of any vaccine containing antigens Bordetella pertussis.

A strong reaction that developed within 48 hours after a previous vaccination with a vaccine containing a pertussis component: an increase in body temperature to 40 ° C and above,

syndrome of long-term unusual crying, febrile or afebrile seizures, hypotonic-hyporeactive syndrome.

Allergic reaction after previous vaccine administration
for the prevention of diphtheria, tetanus, whooping cough, polio and vaccines for the prevention of infections caused by Haemophilus influenzae like b.

A confirmed systemic hypersensitivity reaction to any vaccine ingredient, as well as glutaraldehyde, neomycin, streptomycin and polymyxin B.

Diseases accompanied by fever, acute manifestations of an infectious disease or exacerbation of a chronic disease. In these cases, vaccination should be postponed until recovery.


If a child has a history of febrile convulsions that are not associated with prior vaccination, the body temperature of the vaccinated person should be monitored within 48 hours after vaccination and, if it is increased, use antipyretic (antipyretic) drugs regularly throughout this period.


The vaccine is injected intramuscularly in a dose of 0.5 ml, the recommended injection site is the middle third of the anterior-lateral surface of the thigh. Do not inject intradermally or intravenously. Before the introduction, you must ensure that the needle does not penetrate into the blood vessel.
For the option of packaging with two separate needles, before preparing the vaccine, the needle should be firmly fixed, rotating it a quarter turn relative to the syringe.

To prepare the vaccine, after removing the plastic colored cap from the vial, completely inject the suspension for intramuscular administration (vaccine for the prevention of diphtheria, tetanus, whooping cough and polio) through a needle from a syringe into the vial with lyophilisate (vaccine for the prevention of infection caused by Haemophilus influenzae type b) .

Shake the vial without removing the syringe from it, and wait until the lyophilisate is completely dissolved (no more than 3 minutes). The resulting suspension should be turbid and have a whitish tint. The vaccine should not be used in case of discoloration or the presence of foreign particles. A vaccine prepared in this way should be fully collected in the same syringe. The finished vaccine should be administered immediately.

PENTAXIM vaccination course consists of 3 injections of one dose of vaccine (0.5 ml) with an interval of 1-2 months, starting from 3 months of age. Revaccination is performed by administering 1 dose of PENTAXIM at the age of 18 months. of life.

In accordance with the National preventive vaccination calendar of the Russian Federation, a vaccination course for the prevention of diphtheria, tetanus, whooping cough and polio consists of 3 doses of the drug at 1.5 month intervals, at the age of 3, 4.5 and 6 months, respectively, revaccination is carried out once at the age of 18 months.

In case of violation of the vaccination schedule, the subsequent intervals between the introduction of the next dose of the vaccine do not change, including the interval before the 4th (revaccinating) dose - 12 months.

If the first dose of Pentaxim was administered at the age of 6-12 months, then the second dose is administered after 1.5 months. after the first, and as the 3rd dose, administered after 1.5 months. after the second, the vaccine for the prevention of diphtheria, tetanus, whooping cough and polio, originally presented in a syringe (i.e., without diluting the lyophilisate in a vial (HIb)), should be used. As a revaccinating (4th dose), the usual dose of Pentaxim (with dilution of lyophilisate (HIb)) is used.

If the first dose of Pentaxim is administered at the age after 1 year of life, then for the 2nd, 3rd and 4th (revaccinating) dose, the vaccine for the prevention of diphtheria, tetanus, whooping cough and polio, initially presented in a syringe, without diluting the lyophilisate should be used in a bottle (HIb).

Where produce Pentaxim

You can vaccinate your baby in the vaccination center, in a private clinic or in a normal clinic for children.

However, public clinics sometimes refuse to vaccinate with imported vaccine (perhaps this is due to the responsibility of how the purchased product was stored and transported before being sent to the clinic). In some cases, there is a solution: parents in pharmacies order the drug, vaccination rooms of clinics receive it and then vaccinate.

Vaccinate your children in a timely and efficient manner, and they will always be healthy.