Man's health

Analogues of the drug Biseptol 480

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Being a combined antibacterial drug, Biseptol has a wide range of bactericidal action. As a review of this medicine, I could offer my own. Once I even called him a panacea for all my troubles. Of course, this is not entirely true, but after surgery for osteomyelitis of the spine, the doctors recommended that I take Biseptolum (tablets) at the slightest hint of a cold or infection. I must admit that for more than 15 years there have been no repeated operations. Perhaps this drug has played a role.

This is not surprising, since in many infectious and inflammatory pathologies, the drug Biseptol 480 is prescribed. The instruction recommends its use in the following diseases:

  • Bronchitis, pneumonia, purulent pleurisy and other infectious diseases of the respiratory tract, including lung abscess.
  • Prostatitis, urethritis, pyelonephritis - infections of the urogenital system.
  • Sexually transmitted diseases.
  • Infectious diseases of the digestive tract.
  • Infectious diseases of the skin, soft tissue infections: pyoderma, furunculosis and others.
  • Otitis, sinusitis.

Also, the drug "Biseptol 480" is effective in treating other infections, inflammatory processes caused by microorganisms that are sensitive to the action of this drug. It is used in the treatment of cholera, acute and chronic osteomyelitis. As already mentioned, the drug is combined, that is, consisting of several components. These are sulfamethoxazole and trimethoprim. Apply the drug "Biseptol 480" tablets as follows:

  • For children from two to five years old, the dose of the drug is 480 mg per day - two (120 mg) tablets in the morning and evening.
  • For children under the age of 12 years, "Biseptol 480" is prescribed at the rate of 960 mg per day. This is twice a day, four (120 mg) tablets or one each - 480 mg.
  • In pneumonia, the content of sulfamethoxazole is taken into account. Per 1 kg of patient weight per day 100 mg of the substance is allowed, and the intake is divided into three times.
  • The daily dose for children over 12 years old and adults is 1 g 920 mg (960 mg twice a day). If long-term therapy is needed, 480 mg twice a day.

The medicine should be taken after meals. It is necessary to wash down tablets with water in small quantities. Between receptions should be equal intervals of time. Usually this period is 12 hours. This means that if the morning dose of the medicine is taken at 8-00, then the evening one will be taken at 20-00. Accordingly, if the drug "Biseptol 480" is prescribed for three times use, then the interval between doses is 6 hours. Then it happens, for example: 8 am - the first reception, 2 pm - the second reception and 8 pm - the third.

The effectiveness of drug treatment largely depends on the regularity and timeliness of its use. The course of therapy lasts up to two weeks. Dosage and treatment are prescribed individually. If the course exceeds five days, hematological monitoring is carried out. With changes in the blood picture, folic acid is prescribed.

My good review of the drug "Biseptol 480" does not mean that all readers should also treat any inflammatory processes with this medicine. He was prescribed by the attending physician, who knew exactly what microorganisms sepsis was caused, and then osteomyelitis of the spine.

Contraindications for taking Biseptol:

  • Severe liver and kidney dysfunctions.
  • Any disorders related to the hematopoietic system.
  • Severe pathologies of the cardiovascular system.
  • Age up to three months.
  • Hypersensitivity to the components of the drug.

Also Biseptol is not prescribed during pregnancy.

An overdose of the drug is accompanied by clouding of consciousness, nausea and vomiting. Gastric lavage and heavy drinking are recommended as first aid. Of course, in such cases, you should call an ambulance. When sharing biseptol with other drugs should consult a doctor.

Drug description

Biseptol 480 - Combined antibacterial drug containing sulfamethoxazole, which has an average duration of action, inhibiting the synthesis of folic acid by competitive antagonism with para-aminobenzoic acid, as well as trimetolrim-inhibitor of bacterial reductase dihydrofolic acid. The combination of both drugs gives an energetic effect of antibacterial action, and therefore bacterial resistance appears less frequently than other drugs.

Biseptol has a broad spectrum of antibacterial action. is he active against : Streptococcus (Streptococcus pneumoniae), Neisseria meningitidis, Neisseria gonorrhoeae (including enterotoksogennye strains), Staphylococcus, Escherichia coli, Klebsiella, Enterobacter, Proteus mirabilis, Proteus spr, Haemophilus influenzae, Salmonella spp.. (including Salmonella typhi and Salmonella paratyphi), Vibrio cholerae, Bacillus anthracis, Listeria spp., Nocardia asteroides, Bordclella pertussis, Enterococcus faecalis, Pasteurella spp., Brucella spp., Mycobacterium spp. (including Mycobacterium leprae), Citrobacter, Enterobacter spp., Legionella pneumonia, Providencia, some species of Pseudomonas (except P. aerugenosa), Serratia marcescens, Yersinia spp., Morganella spp., Chlamydia spp. (including Chlamydia trachomatis, Chlamydia psittaci), Shigella, Plasmodium spp., Toxoplasma gondii, Pneumocystis carini, Actinomyces israelii, Coccidioides immitis, Histoplasma capsulatum, Leishmania spp.

Resistant to the drug: Corynebacterium spp., Pseudomonas aerugenosa, Mycobacterium tuberculosis, Troponema spp., Leptospira spp., Viruses.

Inhibits the vital activity of Escherichia coli, leads to a decrease in the synthesis of thiamine, riboflavin, nicotinic acid and other B vitamins in the intestine. The duration of the therapeutic effect is 7 hours.

BISEPTOL 480

Tradename
Biseptol 480

International non-proprietary name of active ingredients
Co-trimoxazole [Sulfamethoxazole + Trimethoprim]

Dosage Form
Concentrate for solution for infusion

The composition of 1 ml of concentrate
Active substances: sulfamethoxazole 80.00 mg + trimethoprim 16.00 mg
Excipients: propylene glycol 400.00 mg, ethyl alcohol 96% 100.00 mg. benzyl alcohol 15.00 mg, sodium disulfite (E223) 1.00 mg. sodium hydroxide 12.63 mg, sodium hydroxide 10% solution to a pH of 9.5 - 11.0, water for injection to 1 ml. 1 vial (5 ml) contains 400 mg of sulfamethoxazole and 80 mg of trimethoprim.

Description
Transparent colorless or slightly yellowish liquid.

Pharmacotherapeutic group
Antimicrobial agent combined.

ATX code: J01EE01

Contraindications

  • Hypersensitivity to sulfonamides, trimethoprim, co-trimoxazole or any auxiliary component of the drug,
  • severe damage to the liver parenchyma,
  • severe renal failure (CC less than 15 ml / min),
  • liver failure,
  • severe hematological disorders: aplastic anemia, B12-deficient anemia, agranulocytosis, leukopenia, deficiency of glucose-6-phosphate dehydrogenase,
  • the administration of a drug diagnosed with porphyria or patients who are at risk of developing acute porphyria should be avoided, because The drug may increase the symptoms of this disease.
  • children up to 3 years old (with the exception of treatment or prevention of pneumonia caused by Pneumocystis jiroveci),
  • pregnancy and lactation.

    Carefully
    Care must be taken when prescribing Biseptol 480 patients with folic acid deficiency (for example, people with alcohol dependence, treatment with anticonvulsants, malabsorption syndrome and the elderly), patients with bronchial asthma and severe allergies, patients with diseases of the circulatory system and respiratory system, because after the introduction of high doses, excessive hydration may occur in patients with thyroid disease. Special care is recommended in elderly patients, as this group is more susceptible to side effects and more pronounced side effects, especially with concomitant diseases, such as renal failure and (or) abnormal liver function and taking other medications.

    Pregnancy and lactation

    You should not prescribe the drug during pregnancy and during breastfeeding.

    Influence on ability to steer the car and other mechanisms
    During the period of treatment, care must be taken when driving vehicles and engaging in potentially hazardous activities that require increased concentration and psychomotor reactions.

    Release form and packaging
    Concentrate for solution for infusion (80.00 mg + 16.00 mg) / ml. On 5 ml in ampoules from colorless hydrolytic glass (class 1, Heb. Pharm.). Above the notch of the ampoule is a dot of white or red, as well as a strip in the form of a ring of yellow. On 5 ampoules place in the pallet for ampoules from PVC. Two pallets in a cardboard pack with instructions for use.

    Vacation conditions

    Manufacturer and owner of registration certificate
    JSC Warsaw Pharmaceutical Plant Polfa
    st. Karolkowa 22/24, 01-207 Warsaw, Poland.

    Representation in the Russian Federation:
    121248 Moscow, Kutuzov Avenue, 13, office 85

    The information on the page is verified by a general practitioner Vasilyeva E.I.

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    Release form and composition

    The dosage form of Biseptol 480 is a concentrate for preparing a solution for infusions: a clear, colorless or light yellow liquid with a characteristic smell of ethanol (5 ml each in ampoules, in a cardboard bundle there are 2 blister packs or 10 ampoules without packaging).

    The composition of the concentrate in 1 ml / 1 ampoule:

    • active ingredients: sulfamethoxazole - 80/400 mg, trimethoprim - 16/80 mg,
    • excipients: sodium hydroxide, sodium metabisulphite, propylene glycol, benzyl alcohol, ethanol, water for injection.

    Pharmacodynamics

    Biseptol 480 - combined antibacterial drug. The active components in its composition: sulfamethoxazole is an effective antimicrobial substance of medium duration, inhibiting the synthesis of folic acid by competitive antagonism with para-aminobenzoic acid, trimethoprim is a bacteriostatic antibiotic that inhibits bacterial reductase of dihydrofolic acid. Their combination gives synergism of antibacterial action, in connection with which the effectiveness of such a complex is much higher in comparison with the effect of other drugs.

    Biseptol 480 is a broad-spectrum antibiotic; it is active against the following microorganisms: Streptococcus (Streptococcus pneumoniae), Neisseria gonorrhoeae (stoitogenic strains incl), Neisseria meningitidis, Staphylococcus, Klebsiella, Escherichia, Ichralia, Ifexia, Icytheria meningitidis, Staphylococcus, Klebsiella, Ichra, Ichra, Ipc mirabilis, Salmonella spp. (Salmonella typhi and Salmonella paratyphi inclusive), Vibrio cholerae, Bacillus anthracis, Listeria spp., Nocardia asteroides, Bordetella pertussis, Enterococcus faecalis, Pasteurella spp., Brucella spp., Mycocoterter ppp, Ps. (Mycobacterium leprae inclusive), Enterobacter spp., Citrobacter, Legionella pneumonia, Providencia, some species of Pseudomonas (excluding P. aeruginosa), Serratia marcescens, Morganella spp., Yersinia spp., Chlamydia spp. (Chlamydia trachomatis and Chlamydia psittaci inclusive), Actinomyces israelii, Shigella, Toxoplasma gondii, Plasmodium spp., Pneumocystis carinii, Histoplasma capsulatum, Coccidioides immitis, Leishmania spp.

    Microorganisms exhibiting resistance to Biseptolum 480: Corynebacterium spp., Mycobacterium tuberculosis, Pseudomonas aeruginosa, Leptospira spp., Troponema spp. and viruses.

    The drug inactivates the vital activity of Escherichia coli, leads to a decrease in the intestinal synthesis of riboflavin, thiamine, nicotinic acid and other B vitamins. The duration of therapeutic action is 7 hours.

    Pharmacokinetics

    Biseptol 480 penetrates tissue of the body and its biological fluids quickly and is well distributed in them. The drug penetrates through the blood-brain barrier (BBB), histohematomatic barrier, is excreted in breast milk. Its concentration in the urine and lungs significantly exceeds the plasma. Vaginal secretions, bronchial secretions, bones, saliva, tissues and secretions of the prostate gland, breast milk, middle ear fluid, bile, cerebrospinal fluid, eye watery moisture, interstitial fluid, sulfamethoxazole and trimethoprim accumulate to a lesser extent. Both active components are distributed differently: sulfamethoxazole - only in the extracellular space, and trimethoprim - both outside the cells and inside them. 66% of sulfamethoxazole and 45% of trimethoprim bind to plasma proteins.

    Both drugs are metabolized in the liver. Sulfamethoxazole is metabolized to a greater extent, forming acetylated derivatives - metabolites that do not possess antimicrobial activity.

    Biseptol is excreted by 480 kidneys, both by glomerular filtration and by active tubular secretion. Up to 80% of the drug is excreted in 72 hours as metabolites, 20% of sulfamethoxazole and 50% of trimethoprim are excreted unchanged. In urine, the concentration of active substances is higher than in blood plasma. Through the intestines the drug is excreted in small quantities. The half-life (T1 / 2) for sulfamethoxazole is 9–11 hours, for trimethoprim - 10–12 hours. In children, this figure is significantly less and depends on the child’s age: in the first year of life it is 7–8 hours, from 1 year to 10 years - 5–6 hours. T1 / 2 increases in elderly patients with impaired renal function.

    Indications for use

    • gastrointestinal infections: paratyphoid fever, typhoid fever, cholera, salmonellosis, dysentery, cholangitis, cholecystitis caused by enterotoxic strains of E. coli (Escherichia coli) gastroenteritis,
    • infections of the reproductive and urinary systems in the acute and chronic course: pyelitis, pyelonephritis, urethritis, cystitis, epididymitis, prostatitis, chancroid, gonorrhea, inguinal granuloma, sexually transmitted lymphogranuloma,
    • infectious lesions of ENT organs: angina, otitis media, laryngitis, sinusitis, scarlet fever,
    • infections of the upper and lower respiratory tract: bronchitis in acute and chronic course, lobar pneumonia, bronchiectasis, pneumocystis pneumonia, bronchopneumonia, lung abscess, pleural empyema,
    • infections of skin and soft tissues: pyoderma, acne, furunculosis, wound infections and abscess, infection after surgical interventions,
    • other infectious diseases: sepsis, toxoplasmosis, acute brucellosis, osteoarticular infections, osteomyelitis, malaria (Plasmodium falciparum), South American blastomycosis, whooping cough (as part of a comprehensive treatment).

    Instructions for use Biseptol 480: method and dosage

    The solution prepared from the Biseptol 480 concentrate must be administered intravenously (iv) drip. You can not use the drug in the form of a quick IV injection.

    The following infusion solutions are allowed to dilute Biseptol 480 concentrate: 5 and 10% dextrose solutions, 0.9% NaCl solution, 0.45% NaCl solution with 2.5% dextrose solution, Ringer's solution.

    • children under 12 years of age: the daily dose is determined at the rate of 36 mg per kg of body weight and is divided into 2 administrations in equal amounts,
    • children over 12 years old and adult patients: 960 mg (10 ml or 2 ampoules) 1 time per 12 hours, if necessary, a single dose up to 1440 mg (15 ml or 3 ampoules) is allowed, 2-3 times a day.

    Breeding concentrate Biseptol 480 is recommended in the following proportions:

    • 5 ml (1 ampoule) of the drug - 125 ml of infusion solution,
    • 10 ml (2 ampoules) of the drug - 250 ml of infusion solution,
    • 15 ml (3 ampoules) of the drug - 500 ml of infusion solution.

    With an infusion solution other than the above, or other drugs, the prepared Biseptol 480 solution should not be mixed.

    Patients with renal insufficiency with CC from 15 to 30 ml / min reduce the dose of the drug by 1/2 of the average therapeutic.

    Side effects

    When applied according to indications in compliance with the dosing regimen, Biseptol 480 is usually well tolerated by patients, but such side effects are possible:

    • central nervous system: headaches, dizziness, in some cases - apathy, depression, tremor, aseptic meningitis, peripheral neuritis,
    • GIT: vomiting, nausea, diarrhea, anorexia, abdominal pain, gastritis, glossitis, stomatitis, increased activity of liver enzymes, cholestasis, hepatitis, pseudomembranous enterocolitis, liver necrosis,
    • respiratory system: bronchospasm, pulmonary tissue infiltration,
    • hematopoietic organs: rarely - leukopenia, neutropenia, thrombocytopenia, agranulocytosis, megaloblastic anemia, hypoprothrombinemia,
    • urinary system: renal dysfunction, interstitial nephritis, polyuria, hematuria, crystalluria, hypocreatininemia, increased urea level, toxic nephropathy with a decrease in diuresis to oliguria and anuria,
    • musculoskeletal system: myalgia, arthralgia,
    • hypersensitivity reactions: rash, pruritus, polymorphic erythema, exfoliative dermatitis, photosensitization, allergic myocarditis, hyperthermia, sclera redness, angioedema,
    • reactions at the injection site: soreness, thrombophlebitis,
    • Other: hypoglycemia.

    Overdose

    Symptoms of overdose are 480 Biseptol intestinal colic, nausea, vomiting, headache, dizziness, depression, fainting, drowsiness, confusion, fever, blurred vision, crystalluria, hematuria, due to a prolonged overdose leucopenia, thrombocytopenia, jaundice, megaloblastic anemia.

    Для терапии состояния необходимо:

    • промыть пациенту желудок,
    • обеспечить прием препаратов, вызывающих подкисление мочи, для усиления выведения триметоприма,
    • увеличить прием жидкости внутрь,
    • для устранения действия триметоприма на костный мозг вводить внутримышечно кальция фолинат в дозе 5–15 мг /сут,
    • in order to stimulate erythropoiesis, when trimethoprim suppresses the hematopoietic functions of the bone marrow, to inject intramuscularly folic acid at a dose of 3–6 mg / day, for a course of 5–7 days,
    • if necessary, conduct hemodialysis.

    special instructions

    When Biseptol 480 is used in patients with acquired immunodeficiency syndrome (AIDS), who use co-trimoxazole for the treatment of pneumocystic pneumonia, such undesirable effects, such as hyperthermia, skin rashes, leukopenia, are more common.

    It is desirable to determine the concentration of sulfamethoxazole in plasma every 2–3 days immediately before the next infusion, if its value is> 150 μg / ml, the therapy should be interrupted until the plasma value drops to 120 μg / ml.

    Prolonged treatment is required under systematic monitoring of the functional state of the liver and kidneys, as well as peripheral blood parameters.

    In order to prevent crystalluria in patients, it is necessary to maintain a sufficient amount of urine excreted.

    Due to the deterioration of the filtration function of the kidneys, the probability of allergic and toxic complications in the application of sulfonamides significantly increases.

    Against the background of treatment, it is inappropriate to eat foods containing para-aminobenzoic acid (PABA) in large quantities - tomatoes, carrots and green parts of vegetables (cauliflower, spinach, beans).

    Due to the likely increase in photosensitivity when Biseptol 480 is applied, excessive solar and artificial ultraviolet irradiation should be avoided.

    It is not recommended to use an antibiotic for pharyngitis and tonsillitis caused by beta-hemolytic streptococcus group A due to the wide prevalence of resistant strains.

    In case of impaired renal function

    • renal failure with QC 25 mg per week): increases the likelihood of megaloblastic anemia,
    • diuretics (mostly thiazide): increase the risk of thrombocytopenia,
    • procainum, procainamide, benzocaine, other drugs, the hydrolysis of which produces PABA: reduces the effectiveness of co-trimoxazole,
    • barbiturates, phenytoin, para-aminosalicylic acid (PAS): increase the manifestations of folic acid deficiency,
    • hexamethylenetetramine, ascorbic acid, other urinary acidifying drugs: increase the likelihood of crystalluria,
    • salicylates: enhance the effectiveness of the drug,
    • colestyramine: inhibits the absorption of co-trimoxazole, so it must be taken 1 h after or 4–6 h before the use of Biseptol 480,
    • oral contraceptives: their reliability is reduced due to inhibition of the intestinal microflora and a decrease in the enterohepatic circulation of hormonal compounds.

    Between diuretics (furosemide, thiazides, etc.) and hypoglycemic drugs for oral use (sulfonylurea derivatives) on the one hand, and sulfonamides on the other, a cross-allergic reaction is possible.

    Analogues of Biseptol 480 are Co-trimoxazole, Bactrim, Briefeptol, Bi-Septin, Dvaseptol, Metosulfol and others.

    Biseptol 480 Reviews

    For a long time, Biseptol was the drug of choice in the treatment of most infectious lesions. Today, there are numerous discussions about the ratio of the effectiveness and toxicity of the drug, both at the level of scientific discussions and among patients using an antibiotic. Therefore, reviews of Biseptol 480 are sometimes diametrically opposed, and to make an unambiguous conclusion about the advisability of using the drug at the moment is difficult. In such a situation, the best option would be to follow the advice of specialists you trust.

    The price of Biseptol 480 in pharmacies

    Approximate price of Biseptol 480 per 10 ampoules of concentrate for preparing a solution for infusion of 5 ml is 415 rubles.

    Education: First Moscow State Medical University named after I.М. Sechenov, specialty "Medicine".

    Information about the drug is generalized, is provided for informational purposes and does not replace the official instructions. Self-treatment is dangerous to health!

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    Composition and action

    Active ingredients: sulfamethoxazole, trimethoprim (in Latin - Sulfamethoxazolum and Trimethoprimum).

    Excipients: alcohol, sodium hydroxide, sodium metabisulfite, prepared water for injection.

    Action: the active substances of the drug enter into a chemical interaction, causing damage to pathogens sensitive to sulfamethoxazole and trimethoprim. The highest efficacy of the drug is observed in the treatment of urological and urinary diseases, diseases of the liver and pancreas.

    Concentrate

    The concentrate is a colorless or light yellow liquid, packaged in ampoules.

    Tablets are round, light yellow color. They are flat, rounded at the edges, engraved on one side.

    With urethritis

    Kills pathogens, leading to the development of inflammation of the urogenital canal.

    Biseptol relieves pain when urinating, swelling.

    Take the drug to be under the supervision of a physician.

    Nephritis is a serious disease of the kidney tissue. Biseptol helps to avoid intoxication, eliminate diarrhea, nausea and acute pain in the kidney area.

    How to take Biseptol 480 for urinary tract infection

    Dosage for urinary tract infections may vary depending on the type of disease, as well as its severity. Biseptol tablets are taken orally, washed down with plenty of water.

    The standard dosage for adults is 2-3 tablets of the drug per day.

    In severe infections, the dosage is temporarily increased. After the rate of infection has decreased, supportive therapy is prescribed (1 tablet per day).

    Biseptol 480 is pre-diluted in water and injected intravenously. 2 ampoules of medication are diluted in 250 ml of saline. The solution is injected every 12 hours.

    For children from 6 to 12, there are lower doses (1 tablet per day, 1 ampoule at 12 o'clock).

    How many days to drink

    The course of treatment varies depending on the severity of the disease and the patient's state of health. The minimum course of treatment is 7 days.

    In the treatment of severe infectious diseases and a complicated form of pneumonia, the medicine must be taken for 2-3 weeks. At the same time, the patient’s state of health is monitored. If an overdose symptom occurs, the course immediately stops.

    Drug interaction

    Do not use the drug with dofetidil. This is fraught with problems with the cardiovascular system.

    When interacting with anticoagulants and nonsteroidal antiseptics increases the likelihood of adverse reactions. Biseptol reduces the effectiveness of contraceptive drugs.

    Use in conjunction with diuretics can lead to a decrease in the number of platelets in the blood. At the same time taking Biseptol and diuretics increases the risk of bleeding.

    Different analogues of this drug are available for sale:

    1. Bakteptol.
    2. Co-trimoxazole.
    3. Groseptol.
    4. Solyseptol.
    5. Triseptol.

    These drugs are similar to Biseptol in composition and chemical properties.

    Genitourinary system

    Used for manifestations:

    Biseptol 480 contributes to the treatment of sexually transmitted diseases:

    • gonorrhea
    • soft chancre,
    • venereal lymphogranuloma.

    Digestive system

    Biseptol 480 helps in the fight against dangerous infections:

    • cholera,
    • dysentery,
    • typhoid fever
    • paratyphoid
    • gastroenteritis caused by a strain of E-coli,
    • salmonellosis.

    Other diseases

    Biseptol 480 is used both in combination and independently, if the pathogen has shown resistance to previously prescribed antibacterial agents. Indications:

    • malaria,
    • whooping cough,
    • acute brucellosis,
    • toxoplasmosis,
    • sepsis,
    • osteomyelitis.

    Dosage of biseptol 480

    Regardless of the method of administration, adolescents from 12 years old and adults are given 960 mg of the drug (2 5 ml ampoules or 2 tablets) every 12 hours. Children from 3 to 5 years give ½ pills at the reception, from 6 to 12 years - 1 pill. Elderly people at a time

    You can take no more than 480 mg medication. The single dose is halved when the treatment lasts longer than 5 days.

    The doctor may increase the dosage for severe diseases, if the patient has shown good tolerability. With pneumonia, medicine must be taken every 6 hours.

    For gonorrhea, a one-day course is prescribed: twice in 5 pills, with an interval of 12 hours. One “loading dose” of 6 tablets can be given to women for the treatment of acute cystitis or inflammation of the urinary tract.

    Before or after meals

    Biseptol 480 is taken after meals with 100-150 ml of water.

    Interaction

    When prescribing a medication, it is necessary to establish which other medications the patient is taking, since some of them showed incompatibility with Biseptol. Combination with Dofetilide can cause such significant heart rhythm disturbances that in some descriptions the combination of these drugs is listed as a contraindication.

    With other drugs

    Liquid for injection can not be combined with the introduction of products containing bicarbonate. For dilution is allowed to use solutions of NaCl, dextrose, Ringer. The drug should not be prescribed to patients taking cyclosporine after kidney transplantation, since such a combination will result in impaired functioning of the transplanted organ.

    The tool increases anticoagulant activity and prolongs the prothrombin time of the drugs taken to reduce blood clotting (Warfarin, etc.). In order to avoid the development of anemia, it is not recommended to combine it with taking Pyrimethamine (against malaria).

    Biseptol interferes with the binding of methotrexate to plasma proteins, while increasing the concentration and enhancing its action. In combination with diuretics, thiazides can reduce the number of platelets and increase the risk of allergies. Urine-oxidizing drugs (including vitamin C) increase the likelihood of crystalluria.

    Simultaneous administration with Procainamide or Amantadine mutually increases the concentration of drugs in the blood serum. The effect of the drug is enhanced by salicylic acid and its derivatives. Effectiveness may decrease when interacting with Procainamide, Benzocaine and other medications that form vitamin B10 after hydrolysis.

    Features of use Biseptol 480

    In patients with allergies and asthma in the history of the appointment made from a half dose. Analyzes are regularly done at high dosage, prolonged treatment, and in patients who have an electrolytic balance disorder. When changing the composition of the blood, you must additionally assign PABK (vitamin B10). If the indicators are normal, during treatment should not be carried away with products with a high content of this vitamin. Must be protected from excessive UV exposure.

    It should be noted that in AIDS patients who took the agent for the treatment of infections against the background of this disease, some side effects were much more common. These include hyperkalemia, hypoglycemia, anemia, leukopenia, and anaphylactic reactions.

    In order to avoid the development of anemia, it is not recommended to combine it with taking Pyrimethamine (against malaria).

    Antibiotic or not?

    For a long time, only medicines of natural origin were called antibiotics, and those synthesized were called antibacterial drugs. Now drugs are not classified according to the method of production, but according to the spectrum of influence. In this classification, sulfonamides, to which Biseptol belongs, are allocated to a separate group of antibiotics.

    Do they sell without a prescription?

    Selling funds without an appointment is considered a violation. When ordering via the Internet and buying it out in a pharmacy, the drug will be cheaper, but there you will need to present a prescription written in Latin. With postal and

    Does courier delivery cost a little more expensive, but it is still given without a prescription.

    Packaging of tablets (28 pcs.) Will cost 95-105 rubles, the cost of 10 ampoules is 418-454 rubles.

    Cheaper analogs of Biseptol 480 are Co-Trimoxazole, Dvaseptol and Metosulfol (Russia), Groseptol (Poland / Hungary). More expensive, but not much, are the analogues Biseptin (Netherlands), Bactrim (Switzerland).

    Doctors reviews

    Egor, therapist, Moscow: “Previously, the tool could have cured most of the diseases of bacterial origin. Due to this, many patients began to take it uncontrollably and often. This has developed resistance in pathogens, which has made the drug less effective. I stopped recommending him and I also do not meet him in the appointments of other doctors. ”

    Elena, infectious diseases specialist, Ufa: “The second breath received the drug with the spread of diseases against the background of HIV infection, which are difficult to treat with other medicines. A positive result appears after 3-4 days. However, side effects are much more common in AIDS patients: rash, erythema sulfonamide. ”

    Reception of funds is possible only with constant monitoring of the functioning of the urinary system and kidneys.

    Patient Reviews

    Nonna, 44, Kaliningrad: “The medicine has been helping out for many years. Despite the fact that almost no one writes him out now, at the first signs of a sore throat I immediately take 1-2 pills for 3 days. But if you miss the onset of the disease, the remedy no longer helps. ”

    Tatiana, 27 years old, Saransk: “Bronchitis did not go away for a long time, antibiotics prescribed by a doctor only improved a little. Mom remembered about the drug, which was once treated by herself, and after 5 days of treatment, the bronchitis was completely gone. But there was an adverse reaction: her lip was swollen and her palms were itching. I had to ask the pharmacy also an allergy medicine. ”

    Marina, 35, Yaroslavl: “When I got sick with cystitis, the doctor prescribed a large number of pills, which she took for 2 weeks. Then there was inflammation of the kidneys, I had to go to the hospital. They were treated with antibiotic injections. Six months later, cystitis began again, and another doctor prescribed Biseptol. Condition improved after 3 days. Then she twice suffered from cystitis and “jammed” him with this medicine. 10 years have passed since the last attack. There was a side effect - diarrhea, but it passed as soon as I stopped taking the drug. ”

    Svetlana, 42, Chelyabinsk: “When, after a severe flu, a 14-year-old son was diagnosed with pyelonephritis, they began to prescribe antibiotics, they are different every week. He swallowed the pills for almost a month, completely weakened because of them, but the tests still remained bad. Biseptol was advised by a neighbor, a retired physician. After a 5-day course, the son went on the mend. There were no side effects at all, although at first, it was scary to give the child medicine because of them. ”

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