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What does ASLO show in the blood test

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What is ASLO? Not everyone will solve this abbreviation. So called antibodies against a special type of microorganisms: when a person gets sick with one of many varieties of streptococcal infection, antibodies called anti-streptolysin O are produced in his body. For more convenience in medicine, it is abbreviated ASLO.

The ASLO indicator is a marker of the presence of β-hemolytic streptococcus group A antigen (GABHA) in the body. This harmful microorganism occupies the skin and mucous membranes, has an affinity for connective tissue, causing rheumatism. If the level of ASLO in the blood is elevated, this is a symptom of diseases caused by GABHS. These include, for example, sore throat and scarlet fever. If a biochemical blood test did not reveal this antigen in a person or its fraction is insignificant, then there is no cause for concern, this is quite a normal state of the body. Such results are not only direct evidence of the absence of infection, but also that the person has not had to deal with streptococcus over the past 6 months.

Antistreptolysin O or ASL - O

Before finding out the level of ASLO in the blood, what it is, let's find out more about the antigenic structure of streptococcus. This will help to better understand the production of antibodies.

Gram-positive streptococci secrete enzymes. One such enzyme is streptolysin. It plays an important role in the formation of the immune response, and is toxic to the tissues of the heart, can cause red blood cell hemolysis, a rise in temperature, and the appearance of rash in scarlet fever.

The organism reacts to this aggression by isolating antistreptolysin O. This is how the immune system tries to protect targets - mucous membranes and epidermis. But such antibodies can only eliminate the waste products of bacteria, they are powerless against streptococcus itself. Therefore, without proper and timely treatment can not do.

But when making a diagnosis, it is still worth considering the nuances of increasing the amount of antibodies in a blood test:

  • The beginning of an increase in concentration occurs only at 3-5 weeks of infection,
  • After reaching the maximum mark, the level decreases,
  • High results ASLO able to persist from 6 months. up to a year
  • If measures were not taken on time, and the concentration of anti-streptozilin was high for a long time, then this could turn into complications in the form of rheumatic fever. In this case, the stabilization of indicators occurs after 4-8 months,
  • If for 6 months. ASLO level remains high, then the patient should expect a relapse of the disease, and you need to prepare for the attack.

It is worth noting that in 15% of infected antistreptolysin remains at a normal level, so only this analysis, without taking into account other methods, should not be trusted.

A short video about Streptococcus:

Indications for examination

For timely diagnosis, as well as monitoring the course of the disease, a blood test for antistreptolysin is prescribed.

Streptococcus group A can cause such diseases as:

  • Scarlet fever
  • I give birth
  • Tonsillitis (angina),
  • Pyoderma - purulent lesion of the skin,
  • Rheumatic fever,
  • Glomerulonephritis - damage to the glomeruli.

Without timely medical intervention, the likelihood of complications increases significantly. Can suffer:

  • Joints
  • Heart muscle
  • Renal nephrons,
  • Nervous system.

All this helps prevent the determination of the level of ASLO. Abroad, the passage of such a survey in diseases of the heart, kidneys, nervous system is mandatory for children. And even a year after they are cured, experts prescribe a repeat analysis for antistreptolysin - O. This is done to make a more accurate diagnosis, as well as to exclude the possibility of relapse.

Assign it for the following tasks:

  1. To identify the fact that the patient was infected with streptococcus A recently,
  2. Assess its current status and predict the further course of the disease,
  3. Reveal arthritis in acute rheumatic fever,
  4. Assessment of the condition after 2 weeks of treatment of rheumatism and glomerulonephritis.

A blood test for ASLO is prescribed to take all patients suffering from the following ailments:

  1. Arthritis
  2. Arthrosis,
  3. Pain in the back,
  4. Pharyngitis is an inflammatory process in the mucous membrane and lymphocyte tissue,
  5. Angina,
  6. Laryngitis,
  7. Tracheitis - inflammation in the trachea region,
  8. Nasopharyngitis - inflammation of the nasopharynx,
  9. Scarlet fever.

Biochemical examination is one of the mandatory items of the examination program for patients with rheumatism, glomerulonephritis and myocarditis.

When dispensary treatment, patients have to donate blood 2 times a year before starting an anti-relapse course of therapy. The first delivery is made 30 days after the transferred infectious diseases of the respiratory system. The concentration of antibodies begins to grow in this period, reaching a peak at 6 weeks. Control blood sampling is done six months later, because the body needs exactly that for complete recovery.

Explanation of abbreviations ASLO

What is ASLO? Determining the amount of streptolysin - antigen of b-hemolytic streptococcus group A. Streptococcal microorganisms are always in a small amount on the mucous membranes and skin, so the antistreptolysin O (so called antigen) is always in a small amount in the blood plasma to prevent the development of an infectious process.

The titer of ASLO may increase in the following cases:

  • Streptococcal pathogen has entered the body,
  • exacerbation of the chronic process caused by streptococcus.

The indications for the study may be different, but always laboratory diagnosis helps to identify the infectious process at an early stage.

Indications for appointment

An antistreptolysin blood test should be performed in the following cases:

  • tonsillitis (chronic or acute),
  • scarlet fever,
  • frequent bronchitis, laryngitis or tracheitis,
  • sinusitis,
  • pneumonia,
  • pyoderma,
  • erysipelas,
  • myositis
  • glomerulonephritis,
  • endocarditis and myocarditis,
  • joint damage,
  • osteomyelitis,
  • rheumatic fever.

In the conditions listed above, a blood test for ASLO is considered an essential element of examining a patient.

Having understood what is antistreptolizin, the need for research will become clear. Detection of staphylococcal antigen allows to determine the cause of the disease and select an adequate therapy.

Generally accepted laboratory standards and interpretation of deviations

The presence of antibodies to O streptolysin in the blood when streptococcus enters the body is detected after only 1-2 weeks. This research method allows to detect infection at an early stage. The standard for antistreptolysin norm is:

Interpretation of the results depends on the obtained indicator:

  • Do not exceed the norm. The cause of the disease has become another microbe or a virus, or less than a week has passed since the infection.
  • Antistreptolysin O in ASLO elevated. Streptococcus has entered the body.

The advantage of testing for O streptolysin compared with other methods is that it allows you to detect the presence of streptococcus in the early stages of the disease. The disadvantage is the non-selectivity of the technique, which determines only the presence of antibodies and makes it impossible to assess the state of the immune system, as well as the severity of the disease.

Terms of analysis

To obtain the most reliable analysis on ASLO, preliminary preparation is necessary before the biomaterial is handed over:

  • for a week to stop drinking,
  • on the day before delivery, do not eat large quantities of fat, spicy, spicy and flour (the doctor will issue a memo indicating the list of products to be eliminated or severely limit their use),
  • if possible, to refuse from taking medication within a day,
  • Do not eat or drink water for 12 hours,
  • no smoking in the morning.

Blood sampling does not cause a person great inconvenience. It is carried out from a vein on the elbow with a syringe, and then the material is placed in a special test tube. In some clinics, a vacuum syringe tube is used, which completely prevents microorganisms from entering the blood taken from the air, allowing you to get the most reliable result.

The determination of ASLO in blood is carried out by immunoturbidimetry, which uses the result of a standard antigen-antibody reaction in a scattered light beam. Counting the resulting complexes is carried out using a photometer. The result can be obtained within a few hours after blood has been donated.

The analysis of antistrepretolysin showed that it is possible to find out in the emergency laboratory on the same day, and when conducting a planned laboratory diagnosis, the result will have to wait 1-2 days. This is not due to the complexity of processing the material, but to the fact that the planned laboratories are loaded and the blood is not processed immediately.

What gives the dynamics of research

In case of deviations from the norm of one-off indicators, the magnitude of deviations in dynamics is additionally taken into account (several studies are carried out with a short time interval):

  • standards are increased significantly and continue to grow - infection has happened recently and there is an active production of antibodies,
  • the norm adopted for ASLO is increased slightly and persists for a long time - a chronic inflammatory process takes place in the body,
  • the amount of O streptolysin gradually decreases - recovery occurs or the person is completely healthy, but ASLO is increased slightly due to the residual amount of antibodies.

Increasing ASLO can persist in some people after a cure for a disease for life. This feature is not dangerous to health and does not require treatment, but significantly complicates the diagnosis of infectious diseases.

The reasons for the distortion of the result

ASLO analysis may be incorrect in the following cases:

  • failure to comply with the rules of preparation upon delivery of the material,
  • erythrocyte hemolysis (in hemolytic anemia, it is difficult to count antigen-antibody formations in the light beam),
  • increased cholesterol level
  • liver disease,
  • nephrotic syndrome,
  • use of glucocorticosteroids and antibiotics.

These factors are the reason why a false negative result is often obtained when infected with streptococcus.

The constant presence of the antigen O streptolysin may be due to the characteristics of the organism (as mentioned above), they can cause a false-positive reaction.

When making a diagnosis, a doctor is not guided by only one laboratory test. For the diagnosis using different types of examination, as well as collecting history and examination of the patient.

Reasons for raising

Antistreptolysin increased - what does it mean? This means that streptococcal pathology develops in the body. To provoke its occurrence can:

  • contact with the carrier of the microorganism,
  • visiting places of large concentrations of people (the infection can be transmitted by airborne droplets),
  • the use of common with patient hygiene products (towels, soap),
  • exacerbation of chronic infectious diseases.

The infection with streptococcus itself is not dangerous and is almost always completely cured with the help of antibacterial agents. Hazardous are considered complications in the work of the systems and organs that the microorganism can cause when treatment is begun untimely.

How to avoid complications

A positive analysis of ASLO does not normalize on its own, and long-term infectious processes in case of untimely initiated or incorrectly chosen treatment can provoke a number of complications:

  • inflammation of heart tissue,
  • kidney pathology,
  • rheumatic bone damage
  • various neurological disorders.

In order to avoid the development of a serious pathology, if you increase O streptolysin should follow a number of recommendations:

  1. Do not self-medicate. Even if the antibiotic taken well helped earlier with a staph infection, then with this disease it may be ineffective.
  2. Follow the directions of the doctor. Medicines need to be taken on time and at the prescribed dosage. Therapy for each patient is selected individually, taking into account the characteristics of the disease.
  3. Be wary of unconventional treatments. Some herbs have an antimicrobial effect, but not all of them are combined with prescribed antibiotics. The incompatibility of unconventional drugs and antibacterial therapy often causes serious harm to the body.

Antibiotics for the destruction of staphylococcus have long been selected and are relatively safe. Complications due to improperly prescribed treatment are very rare. More often, the patients themselves aggravate their condition by self-treatment or untimely medication.

The method of ASLO is not quite perfect and has several disadvantages, but it allows you to determine infection with streptococcus in a timely manner. At the initial stage of the disease is easily cured with antibiotics and almost no complications.

ASL-O in the blood: what is it, why is it elevated in children and adults, norms in tests

Antistreptolysin-O (ASLO, ASO) - antibodies directed to streptolysin, which is a β-hemolytic streptococcus antigen Group A (GABHS), spreading on the skin and mucous membranes of the human body.

This laboratory test is of practical importance because of the special "harmfulness" (ability to possess pyogenic properties) of a particular type of microorganism (Streptococcus pyogenes) belonging to the genus Streptococcus. These small globular bacteria (cocci) were discovered at the end of the 19th century, but to this day they, settling in the human body, cause great, often irreparable, harm to their "owner".

About analysis, norms and deviations

To prevent the harm caused by beta-hemolytic streptococcus to the human body, in order to detect the presence of beta-hemolytic streptococcus group A in clinical laboratory diagnostics uses biochemical research of antibodies to the pathogen antigen, briefly called - ASLO.

The norm of the titer of antibodies to streptolysin in different laboratories may differ slightly, however, the following indicators are accepted as the classical variant of normal values:

  • For adults and adolescents (over 14 years old) - up to 200 U / l,
  • For children under 14 years old - up to 150 U / l.

The main methods for determining antistreptolysin-O is the latex test, the analysis is fast and inexpensive, allowing not only to detect a high concentration of antibodies, but also to determine their titer (the kit is completed with the necessary reagents and provides for titration). Some clinicians have more confidence in turbidimetric research, which, however, requires the participation of additional equipment.

Variants of results in dynamics

This laboratory test is suitable for monitoring the course of the pathological process, however, I would like to draw the reader’s attention to the fact that a single study of antibody concentration will not be particularly informative in terms of diagnosis and prognosis, therefore, analyzes should be carried out serially with an interval of one week (7 days).

And here there are various options:

  • The titer of antistreptolysin-O begins to increase about a week from the time of entry of the pathogen. The peak falls on 3-5 weeks and, if everything goes well (the body copes), the level of ASLO will begin to decline and will reach normal values ​​by half a year-year.
  • Persistent increase in antibody concentration the beta-hemolytic streptococcus antigen gives reason to suspect a later complication of the infection - rheumatic fever (rheumatism). The development of the rheumatic process can be assumed after suffering a sore throat (with prolonged, not changing in the direction of reducing the activity of antistreptolysin-O).
  • For a favorable course of rheumatism (without involvement of the heart in the process) indicates (and encourages in terms of the forecast) a decrease in the ASLO titer to normal by the end of the first or second month of the disease. Under the influence of adequate treatment, these periods can be significantly reduced.
  • On the contrary, the absence of changes in the credits ASLO in the direction of decreasing (they remain high after six months from the debut of the disease) complicates the prognosis and makes you think about the onset of relapse.
  • With great diagnostic value This laboratory test (ASLO) still needs to be borne in mind that in the blood of individual patients, which can account for up to 15% of patients with rheumatism, an increase in the antibody titer to streptolysin is not detected. Conversely, a relatively high level is sometimes noted in carriers of the pathogen who do not have any signs of disease. Elevated ASLO titers can also be expected in the blood of people with chronic tonsillitis, rheumatoid arthritis, or in carriers of streptococcal infections who consider themselves healthy, since it is in a state of "hibernation" (albeit until a certain time).

graph: an example of the dynamics of ASLO level in streptococcal infection

It is known that the main cause of increased ASO activity is sensitization of the body with a streptococcal antigen after penetration of a streptococcal infection (in particular, Streptococcus pyogenes - GABHS).

Hope for post-infectious immunity in the event of infection is not particularly necessary - it does not differ either in severity or duration, but allows for a high risk of complications.

Streptococcal infection often leads to the development of a rheumatic process and the formation of acquired heart defects in children, so after suffering a sore throat or other infections in a child it is very important to know the values ​​of this indicator (was the disease caused by streptococcus?).

Meanwhile, such analysis as ASLO is often suggested to be passed to an adult. This test, along with other tests (RF - rheumatoid factor and CRP - an acute phase protein) helps to establish the diagnosis of rheumatoid arthritis, however, with RA, the activity of ASLO is significantly lower than with rheumatism.

Prevent complications

It is extremely difficult to detect GABHS immediately after settlement in the first days of the disease, and it is completely impossible in the blood, after all, it must take time for the streptococcus to become comfortable, and the immune system of the carrier of the infection responds, that is, the immunocompetent cells give the command to activate humoral immunity and produce antibodies directed to the antigenic structure of the infectious agent. These antibodies will be ASLO or antistreptolysin-O - and then you can expect an increased level of the indicator. But until the body detects a “guest” and starts to synthesize antibodies, traces of β-hemolytic streptococcus in the blood of the person who caught the infection will not be detected.

If there is a suspicion, then you can make a smear from the pharynx and plant on blood agar (bacteriological examination), as a result of which colonies of pyogenic flora will grow in 3 days.

Knowing the origin of the inflammatory disease (tonsillofaringitis) is very important when it comes to a child, because only a sore throat of streptococcal etiology needs antibacterial therapy (antibiotics), other processes can do without it. An ASLO study will help avoid the frequent and often unnecessary use of antibiotics and prevent possible complications, the most “expected” of which is acute rheumatic fever.

Recently, hopes have emerged that a vaccine will be created in the near future, stopping the spread of GABHS in the human population, it is currently under development.

This is StrepAvax (composition: sections of M-proteins of the 26 most common β-hemolytic streptococcal serotypes).

Of course, one cannot rely on solving any and all problems with regard to dangerous microorganisms of this kind, but there is also no reason to doubt that using the vaccine will reduce the incidence and the number of complications.

In the meantime, we will hope for such a laboratory criterion as antistreptolysin-O or ASLO, which will help in time to establish the diagnosis, start treatment and prevent complications.

What can show decoding analysis ASLO and what indicators are considered the norm?

Biochemical analysis of blood involves a detailed study, which contributes to the rapid installation of the diagnosis.

If the patient is often sick with angina, pharyngitis, tonsillitis, then the doctor recommends taking an ASLO test.

This indicator of blood represents antibodies that the body produces against antistreptolysin-O.

What is ASLO?

The ASL O analysis is a marker of infection that is caused by group A streptococcus, or a blood test for the presence of antibodies produced against Streptose type O. toxin.

The formation of antistreptolysin in the blood begins at the stage of infection of the body with streptococcal infection.

When streptococcus enters the bloodstream, it releases a toxic substance Streptolysin.

The task of the toxin is to destroy the red blood cells, to expand the toxicity in the body, to hit the heart, and the hemolysis of the red blood cells distorts the results of the analysis.

When the disease is gaining momentum, the body must start producing antibodies in time. Immune cells produce antibodies that fight streptococci.

The antibodies produced are called antitysptoizin-O. The ASLO blood test will determine how much the body can fight the infection itself.

This antistaphylococcal analysis allows the attending physician to see the stage of the disease, its prognosis and the effectiveness of therapy.

Conduct biochemistry on ASLO and adults and children. Most often, the analysis is given to kids who have suffered a staphylococcal infection. The result of infection are diseases of the heart, kidneys, nervous system and joints.

Why conduct a test on ASLO?

Adult patients also have to take a blood test for ASLO. There are a number of reasons that require blood donation for antistreptolysin-O:

  1. for the timely determination of the time of infection with streptococcus type A,
  2. to assess the likelihood of complications after an infection (sore throat, acute tonsillitis, scarlet fever),
  3. for the diagnosis of rheumatoid arthritis, which is provoked by rheumatic fever,
  4. to evaluate the effectiveness of treatment (2-3 weeks after the main stage of treatment of rheumatism and glomerulonephritis),
  5. to compare the symptoms of streptococcal infection with the development of pathologies of the heart, kidneys, joints in children.

These are the five basic reasons that help doctors diagnose a disease associated with staphylococcal A on time to prescribe therapy.

Do I need training, and what norms?

Not all patients know what antistreptolysin-O is in a blood test, so they do not know what preparation the analysis requires. The substance has a high sensitivity, and the products affect its quantity.

Important! An experienced doctor will warn the patient that the test is fasting.

To make the analysis as objective as possible, you need to re-donate blood, but one week after the first procedure.

Material intake from a child

Only in this mode, the doctor will see the dynamics of the disease.

The blood test for antistreptolysin-O has its own norms:

  • for adults - less than 250 IU / ml,
  • for a child from 7 to 14 years old - 150-200 IU / ml,
  • for children up to 7 years old - up to 100 IU / ml.

Such a simple preparation is possible for adults and children. The main thing is that for adult patients, 1-2 days prior to blood sampling, do not drink alcoholic beverages, do not smoke before the procedure.

In order for the results of the analysis to be true, it is necessary to donate blood in one clinic in the morning. Often the allowable rates in different medical laboratories differ.

ASLO blood test: decoding

Not all patients understand what ASLO positive and negative results mean.

A negative test is not important information, as in the diagnosis of such a result does not matter.

When the blood test for ASLO is higher than normal, the doctor proceeds to a detailed study of the patient’s history.

Increased ASLO doctors diagnosed with:

  • rheumatism (positive rheumatic test in the form of analysis for CRP and RF is diagnosed in 85% of patients),
  • chronic pharyngitis, otitis, tonsillitis, sinusitis, pharyngitis,
  • osteomyelitis
  • scarlet fever
  • pyoderma,
  • diffuse glomerulonephritis,
  • erysipelas inflammation.

Important! A table with high levels of ASLO indicates a recent infection. If the figures are close to normal, but still too high, then this state indicates a long-standing infection.

There are several indications for donating blood to ASLO if a person is sick with tuberculosis, has liver disease or high levels of harmful cholesterol (LDL). A relatively low level of antistreptolysin-O in the blood test can be in children from 6 months to 2 years.

What are the consequences of a streptococcal infection?

When is it appropriate to take an ASLO test? What shows and what treatment is necessary with the growth rate? Often such questions can be heard, since many do not understand what diagnoses the level of antistreptolysin. If time does not reveal the active growth of these antibodies, the treatment will be long.

Often, antibiotic therapy is used to normalize the rate and combat streptococcal infection. Only not always prescribed antibiotics are effective. Often, due to improperly prescribed therapy, patients experience complications.

Common types of complications are glomerulonephritis or rheumatic fever. These diseases are most often manifested in the form of complications in children. Features of rheumatic fever manifest themselves:

  1. high body temperature
  2. redness on the skin
  3. enlargement of the joints
  4. shortness of breath
  5. soreness in the heart.

Important! If time does not begin treatment, the probability of heart disease is high.

As for glomerulonephritis, patients feel:

  • decrease in urine volume,
  • blood appears in the urine,
  • lower back pain
  • feverish state
  • renal failure
  • high blood pressure.

To help diagnose the cause of such conditions helps analysis of ASLO. Decoding is necessary to determine in time the participle of streptococcal infection.

For pregnant women, slightly over-titled ASLO does not pose a danger.

Doctors are convinced that streptococcal infections with proper treatment can not damage the normal childbearing.

If there are no complications after the infection, then the health of the little crumbs in the womb does not threaten anything.

Increasingly, doctors recommend donating blood for ASLO analysis, which shows the high efficiency of the indicator. In order not to treat complications after infection, it is enough to consult a doctor for help in time.

Preparing to visit the laboratory

As with any examination, blood donation at ASLO has its own “tricks” for obtaining the most accurate results. Preparing the body for a visit to the laboratory includes the following items:

  1. The last meal for 8-12 hours
  2. After undergoing antimicrobial or antibacterial therapy, at least 3 weeks should pass,
  3. To limit the use of drugs on the eve of blood donation,
  4. For 24 hours it is prescribed to follow a diet. Sweet, salty, spicy, flour and meat are excluded from the diet,
  5. For 7 days, give up bad habits. In particular, do not consume strong drinks.

Visit the laboratory in the morning before 11.00

How is the research done?

What is the analysis of ASLO and how is it done? For the study, the patient takes venous blood. To do this, use a syringe with a volume of 10 ml.

There are several methods for the determination of antistreptolysin O (ASLO). The most popular is the latex test. Carrying out this analysis does not require much time and cost.

With it, you can not only detect a high content of antibodies in the blood, but also determine their titer (the mass of a substance in a milliliter of serum).

Carry out the procedure as follows:

  • Pre-frozen reagents and blood samples are heated to room temperature,
  • On 2 separate glasses placed on a drop of biomaterial,
  • A positive control is added to the first sample, and a negative one to the second,
  • The next step is the addition of a latex reagent,
  • After the sample is stirred,
  • Then the glass is rotated using a mechanical rotor.

A result greater than 200 IU / ml should indicate that the test for the presence of streptococcus bacteria is positive.

There are medical workers who prefer a different method - turbidimetric titration. This method is good when quantitative measurements are needed. To do this, use such devices as:

ASLO blood cannot be donated once - it will not give all the necessary information for diagnosis and prognosis. That is why to monitor the dynamics of the development of the disease it is carried out 2 times with a break of 7 days, that is, once a week.

If the result obtained in adults or children is 0, this is a completely normal result. The main thing is not to exceed the upper limit of standards. ASL O rate depends on the age of the child. The table below shows the limit values:

In women, as well as men, the upper limit of the standard is 200 U / ml.

There is a slight increase in the norm in children, which corresponds to the age of various streptococcal infections - children's sore throats, and so on, so there are methods by which the children from 7 to 14 years old have an upper limit of the norm than adults.

Description of the indicator

An ASLO test is a blood fluid test that is related to revemoprobes. Thanks to her, she is able to identify heart defects, rheumatoid arthritis, and also to predict their development.

In conducting the study, the laboratory assistant identifies antibodies to the group of hemolytic streptococcus, the production of which is carried out by the human immune system. In order for them to begin to be produced, infection must be penetrated.

Representatives of pathogenic flora occur constantly. But, thanks to the protective functions of the body, the bacteria are not able to penetrate the skin layers and mucous membranes. Therefore, the allocation of toxic substances does not occur.

Aslo is a substance that helps to detoxify toxins, but not the bacteria themselves. These antibodies will be present in the analysis continuously and indicate one hundred percent probability of the presence of infection, as well as streptococcus in the human body. When suppressing the infection process due to antibiotic therapy, the indicators are restored to normal values.

When appointed

In order to diagnose the disease in time and monitor its course, it is necessary to donate blood to determine the level of the indicator ASL-O.

Infection with streptococcal infection, belonging to group A, contributes to the development of the following pathological conditions:

  • erysipelas,
  • scarlet fever,
  • rheumatic fever,
  • angina,
  • pyoderma - damage to the skin of a purulent nature,
  • glomerulonephritis, in which the renal glomeruli are affected.

This study is needed to solve some problems:

  • to reveal that infection with streptococcus A occurred not long ago,
  • assess the general condition of the patient and predict the progression of the disease,
  • establish the development of arthritis in the event of rheumatic fever in the acute stage,
  • evaluate the condition after 14 days of therapeutic measures for glomerulonephritis and rheumatism.

It is necessary to study blood for biochemistry for all people who are diagnosed with such pathologies as:

  • arthrosis,
  • arthritis,
  • laryngitis,
  • back pain,
  • tracheitis,
  • angina,
  • scarlet fever,
  • inflammation of the nasopharynx.

The definition of ASLO in the biochemical analysis of blood is a necessary diagnostic procedure for the development of rheumatism, myocarditis and glomerulonephritis.

Norms in adults and children

The presence of antibodies to streptolysin in the composition of the blood fluid can be detected as early as 7–14 days after infection of the organism. This research method makes it possible to identify the infection at the initial stage of its development..

The generally accepted standards to which the indicators of ASLO must comply are presented in the table below.

Decoding possible results

antistreptolysin - O grows with the following diseases:

  • 85% of patients with acute rheumatic fever,
  • Diffuse glomerulonephritis,
  • Erysipelas,
  • Otitis,
  • Chronic tonsillitis,
  • Scarlet fever
  • Osteomyelitis
  • Pyoderma.

ASLO can be increased in the following categories of people:

  1. TB patients,
  2. With liver dysfunction,
  3. If the level of lipoproteins is elevated,
  4. In healthy people who are only carriers of streptococci, but do not suffer from it.

A slight excess of the standards is a consequence of a long-standing infectious disease. High rates are a sign of recent infection.

Also, a low level of antibodies is observed in children aged 6 months. - 2 years. Low results in diagnostics do not play an important role, therefore a detailed decoding of the data is not required. This can happen due to:

  • Medication: antibiotics, glucocorticosteroids,
  • Nephrotic syndrome (false negative result),
  • Liver problems
  • Hypercholesterolemia.

To double-check the information received, the patient is sent for re-delivery of the analysis after 10 days.

This pathogen, β-hemolytic streptococcus group A quite often provokes the appearance of secondary infectious diseases.

Naturally, in this case, the level of ASLO will be high, since by that time the bacteria are already established in the body (active reproduction, production of toxins).

Complications in the form of secondary infections can be:

  • Meningitis,
  • Infectious - toxic shock,
  • Purulent otitis,
  • Pyoderma
  • Sepsis,
  • Osteomyelitis,
  • Neurological disorders
  • Endocarditis.

Some patients may develop an increased sensitivity to the agent (a tendency to relapse). What does the result of the analysis show in such patients? Level ASLO constantly high.

The origin of the inflammatory process plays an important role in the choice of treatment methods, especially when it comes to a child.

If in case of sore throat it is necessary to resort to antibacterial therapy, in other cases this method of treatment is not so effective.

The study of blood ASLO helps to avoid unnecessary antibiotics and the occurrence of complications.

Additional studies to the above analysis are:

  • Swab from the mucosa of the oropharynx,
  • Ultrasound,
  • Blood and urine test.

Исходя из полученных данных, подбирают группу лекарств и их дозировку. Also taken into account the individual characteristics of the organism, for example, the presence of allergies.

The most popular drugs for adults are:

Take them 2 times a day, 500-1000 mg. The course of treatment is 10 days.

In addition, they take antihistamines (“Suprastin”), anti-inflammatory (“acetylsalicylic acid”, 500 mg 3 times a day, for a week) immuno-strengthening (“Immunal”, tincture of esinacea) and means for normalizing the intestinal microflora (Linex, Hilak -forte"). It is worth thinking about nutrition. Increase the intake of fermented milk products (ryazhenka, sour cream, cottage cheese, kefir).

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What happens with streptococcal infection?

Gram-positive streptococcus bacteria produce enzymes that cause tissue damage. Streptolysin is one of these enzymes.

It has a toxic effect on the heart, violates the conduction of impulses, blocks the respiration of myocardial tissues.

With the penetration of streptococci into the body begins the production of antibodies to streptolysin - antistreptolizina O.

Its level in the blood begins to rise in one to three weeks after infection, in three to five weeks it reaches maximum values, after which it begins to decrease. Low blood levels of ASL-O may persist for half a year or even a year.

If ASLO remains high for a long time, it is likely that acute rheumatic fever will develop, which is a complication of streptococcal infections, such as sore throats. In this case, the indicator returns to normal after 4-8 months with a favorable course. Treatment usually shortens this period.

ASL-O - a marker of streptococcal infection in the body

In rheumatic fever, ASLO does not increase in all patients. In 10-15% this does not happen. A slight increase in antistreptolysin O can be observed with rheumatoid arthritis, but its level in this case is much lower than with rheumatism.

Therefore, this analysis is carried out for the differential diagnosis of lesions of the joints with rheumatism and rheumatoid arthritis.

During the recovery period, the level of ASL-O is reduced compared with the acute phase, therefore, it is used to monitor the dynamics of the course of the disease and the preservation of the activity of streptococci during rheumatic fever.

If within six months after the onset of the disease caused by streptococci, the level of ASL-O does not decrease, we can assume the probability of a relapse.

Streptococcal infection is not excluded in the absence of antistreptolysin O in the blood. The level of ASL-O remains normal in approximately 15% of patients.

Such a study is conducted:

  • to determine that a person has recently been infected with streptococcus A,
  • to assess the possibility of complications after suffering streptococcal infections (sore throats, scarlet fever, erysipelas, and others),
  • for the differential diagnosis of rheumatoid arthritis and arthritis caused by acute rheumatic fever,
  • two weeks after the treatment of glomerulonephritis and rheumatism was started to evaluate how effective the therapy is.

Streptococcal infection has pronounced signs, so it is easily determined. The treatment is carried out with antibiotics.

If the therapy was ineffective or the infection is atypical, there is a chance that complications characteristic of streptococcal infections may develop - glomerulonephritis or rheumatic fever.

Most often they occur in children after scarlet fever or tonsillitis. An ALSO test is performed to establish a link between the symptoms of complications and recent streptococcal infections.

Rheumatic fever is characterized by fever, shortness of breath, pain in the heart, reddening of the skin and swelling around the joints. This disease can lead to heart defects.

Complications after streptococcal infections most often develop in children, for example, after a sore throat

When glomerulonephritis is observed lower back pain and fever, the amount of urine output decreases, blood appears in it. Arterial hypertension and renal failure may develop on the background of the disease.

The analysis on ALS-O allows to determine whether these symptoms are caused by a streptococcal infection, since such signs can be observed in other conditions.

How is the analysis and the rate of ASL-O?

For the study used venous blood, which the patient passes in the morning on an empty stomach. Usually the analysis is carried out twice with an interval of a week. This is the only way to make a diagnosis.

During the analysis, determine the amount of antistreptolysin O in the blood, which is measured in units per milliliter. The norm for adults is from 0 to 200 units / ml. The norm for children is somewhat lower - from 0 to 140 units / ml.

In what cases a study on asl-o is not carried out.

In some cases, this test does not make sense:

  1. When streptococcal lesions of the skin - increase does not occur, because skin lipids destroy streptolysin.
  2. With scarlet fever - the diagnosis is easily made on the basis of clinical manifestations.
  3. With endocarditis streptococcal - enough bacterial research, which is carried out faster.
  4. With osteomyelitis.

Important: the ASLO test is not performed to diagnose an acute infection, since antibodies begin to appear in the blood only one to two weeks after infection.

Elevated ASL-O is observed in the following diseases:

  • acute rheumatic fever (the old name “rheumatism”), in which an increase in the level is observed in 85% of patients,
  • streptococcal infections, such as chronic tonsillitis, otitis, sinusitis, pharyngitis, pyoderma, osteomyelitis, scarlet fever,
  • erysipelas,
  • diffuse glomerulonephritis.

You can also read: Why is RDW elevated in the blood?

ASL-O may increase in some categories of individuals:

  • healthy carriers of streptococci
  • tuberculosis patients
  • persons with liver disease,
  • people with elevated lipoprotein levels.

A slight excess of the normal level of ASL-O indicates a long-standing infection. High values ​​indicate that infection has occurred recently.

ASLO can decline in children from six months to two years.

The reduced level of ASLO in the diagnosis does not matter.

The result may affect:

  • the breakdown of red blood cells (hemolysis distorts the result),
  • liver disease and hypercholesterolemia increase the values
  • antibiotics and glucocorticosteroids, as well as nephrotic syndrome gives a false-negative result.

To obtain a reliable result, usually after ten days, repeat the analysis.

Elevated ASL-O during pregnancy

According to doctors, increasing the level of antistreptolysin does not affect the gestation of the fetus and can not harm the unborn baby.

If a pregnant woman has a high ASLO content, there are no signs of any complications after suffering streptococcal infections, no treatment is provided.

Doctors are very responsible approach to the diagnosis and treatment of streptococcal infections and insist on taking antibiotics, even with a slight increase in temperature and not too pronounced manifestations. In most cases, they are not life threatening, can be easily cured and end in complete recovery.

But you should know that after the diseases caused by streptococci, severe complications can develop in the heart, kidneys, joints, nervous system. Their symptoms usually appear several weeks or months after recovery.

At the same time, the level of ASL-O only increases one to three weeks after infection, so in the first days it is impossible to establish whether the disease is caused by streptococci.

This analysis is relevant mainly for children, since, according to research, in adults there is no such close connection between ASLO and infection with streptococci.

What does ASLO show in the blood test

Aslo in the blood test: what is it? A similar question may arise when referring to this study.

Indeed, many medical cuts seem strange and incomprehensible to patients, and sometimes frighten.

But is there a reason for panic? Let's try to find out what is hidden behind this abbreviation and why this analysis is needed.

When is prescribed?

Such a study is conducted:

  • to determine that a person has recently been infected with streptococcus A,
  • to assess the possibility of complications after suffering streptococcal infections (sore throats, scarlet fever, erysipelas, and others),
  • for the differential diagnosis of rheumatoid arthritis and arthritis caused by acute rheumatic fever,
  • two weeks after the treatment of glomerulonephritis and rheumatism was started to evaluate how effective the therapy is.

Sequelae of streptococcal infections

Streptococcal infection has pronounced signs, so it is easily determined. The treatment is carried out with antibiotics. If the therapy was ineffective or the infection is atypical, there is a chance that complications characteristic of streptococcal infections may develop - glomerulonephritis or rheumatic fever.

Most often they occur in children after scarlet fever or tonsillitis. An ALSO test is performed to establish a link between the symptoms of complications and recent streptococcal infections.

Rheumatic fever is characterized by fever, shortness of breath, pain in the heart, reddening of the skin and swelling around the joints. This disease can lead to heart defects.

When glomerulonephritis is observed lower back pain and fever, the amount of urine output decreases, blood appears in it. Arterial hypertension and renal failure may develop on the background of the disease.

The analysis on ALS-O allows to determine whether these symptoms are caused by a streptococcal infection, since such signs can be observed in other conditions.

In what cases a study on the ASL-O is not conducted.

In some cases, this test does not make sense:

  1. When streptococcal lesions of the skin - increase does not occur, because skin lipids destroy streptolysin.
  2. With scarlet fever - the diagnosis is easily made on the basis of clinical manifestations.
  3. With endocarditis streptococcal - enough bacterial research, which is carried out faster.
  4. With osteomyelitis.

Decoding analysis

Elevated ASL-O is observed in the following diseases:

  • acute rheumatic fever (the old name “rheumatism”), in which an increase in the level is observed in 85% of patients,
  • streptococcal infections, such as chronic tonsillitis, otitis, sinusitis, pharyngitis, pyoderma, osteomyelitis, scarlet fever,
  • erysipelas,
  • diffuse glomerulonephritis.

ASL-O may increase in some categories of individuals:

  • healthy carriers of streptococci
  • tuberculosis patients
  • persons with liver disease,
  • people with elevated lipoprotein levels.

A slight excess of the normal level of ASL-O indicates a long-standing infection. High values ​​indicate that infection has occurred recently.

ASLO can decline in children from six months to two years.

The reduced level of ASLO in the diagnosis does not matter.

What can affect the result?

The result may affect:

  • the breakdown of red blood cells (hemolysis distorts the result),
  • liver disease and hypercholesterolemia increase the values
  • antibiotics and glucocorticosteroids, as well as nephrotic syndrome gives a false-negative result.

To obtain a reliable result, usually after ten days, repeat the analysis.

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