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In which cases prescribe "Cefazolin" during pregnancy: 10 indications

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Everyone knows that during pregnancy, the use of any drugs, especially antibiotics, is contraindicated because they have the ability to penetrate the fetus through the placenta and affect its growth and development. However, it should be noted that the period of childbearing itself provokes the exacerbation of diseases in a chronic form, and also increases the risk of developing new ones, because the woman’s immune protection during this period is greatly weakened. What to do if a pregnant woman needs treatment with antibiotics? In this case, the future mom has a lot of questions about taking antibacterial drugs, their dosage, side effects, etc.

Antibiotics are considered to be substances of biological origin, which are synthesized by microorganisms and adversely affect the growth of bacteria and other microbes. Taking antibiotics can be a threat to the health of the future baby. Some representatives of these substances are generally contraindicated during pregnancy, as they can provoke various developmental anomalies, causing deafness and disability of the child.

And, nevertheless, almost every second pregnant woman is forced to take antibiotics in order to preserve the life of the fetus and the health of herself. For example, the future mommy has pyelonephritis, in this case the whole pregnancy will be accompanied by antibiotic drugs, because this is a vital treatment.

The expediency of the use of antibacterial drugs is determined only by a specialist. But nevertheless every woman should know some things in the period of carrying a baby. In particular:

  • Antibiotic drugs are effective only against bacterial diseases of an infectious nature. In other cases, these drugs are dangerous and harm the body.
  • Sources of SARS and influenza viruses are, therefore, treatment with antibiotics of these conditions is not effective. It is also worth noting that such biological substances do not have analgesic or antipyretic effects. They are not a cough remedy (besides, the causes of cough can be very different from a viral infection to increased sensitivity of the bronchi to external irritants), do not help with intestinal disorders (since they can also have a variety of "roots"), do not treat fungal lesions (skin fungal infections, thrush). In the latter case, special preparations with narrow specificity are used.
  • It is also necessary to remember that taking antibacterial drugs before conception still affects sperm and egg, causing the development of embryonic pathologies.
  • Undesirable, I would say, is contraindicated, taking antibiotic drugs in the first three months of pregnancy (especially from the third to the sixth week), because it is during this period that all organs and systems of the baby are laid. If there is an urgent need for up to five weeks of pregnancy, antibiotic therapy is prescribed with extreme caution, and the treatment of the future mom is carried out under strict supervision by specialists over her condition and the condition of the fetus. However, it is worth remembering that after the end of therapy, the drugs will still have a damaging effect on the organs of the future baby, but without causing any deformities in him.

Therefore, if the mother has an infection that does not threaten her health or the health of the fetus, then it is better to carry out the treatment after twenty-four weeks of pregnancy. In this situation, if the doctor prescribes you antibiotic therapy, you should clarify all its feasibility. The main reasons for the use of antibiotics during pregnancy are acute intestinal infections, pyelonephritis (or inflammation in the renal tissue), sexually transmitted infections, as well as all sorts of serious diseases, for example, inflammatory, septic diseases (complicated by ARVI, bronchitis, sinusitis , pneumonia) and other diseases associated with the activity of pathogenic bacteria. During childbirth, the disease has a more severe course than in a normal state, so it is necessary to begin treatment as soon as possible.

If in the period of carrying a baby, antibiotics are simply necessary, you need to clarify for yourself some of the rules for taking them:

  • One or another type of drug can be prescribed only by the attending physician (no self-treatment!), Taking into account the terms of its use, the general health of the woman.
  • Before a doctor prescribes an antibiotic drug, you should tell the specialist in detail about any health problems that occur before pregnancy, genetic predisposition, and it is especially important to talk about allergic reactions.
  • During the reception is strictly prohibited to change the duration of the treatment course, change the dosage, etc., otherwise you can reduce its effectiveness.
  • In the case of obvious side effects when taking antibiotics, as well as any discomfort sensations from their use should be abandoned immediately.

Effect of antibacterial drugs during pregnancy.
According to numerous studies, it was found that antibiotics do not affect the genetic or hereditary apparatus, do not provoke the occurrence of congenital malformations. And, nevertheless, some types of antibiotics can cause an embryotoxic effect, manifested in impaired renal function, tooth tuck, damage to the auditory nerve, etc.

In the early stages of pregnancy, these drugs are strictly limited to use and are prescribed with great care. Penicillin preparations (Amoxicillin, Oxacillin, Ampicillin, Amoxiclav, etc.) are considered the most preferred for treatment. They even with prolonged use do not contribute to the development of abnormalities in the development of the fetus. But they also have their disadvantages, among them the resistance of some microorganisms to them. In other words, therapy with these drugs for some diseases may not be completely effective.

If antibiotic therapy is needed at an early stage of pregnancy, the doctor, evaluating the pros and cons, may prescribe the future mom antibiotics of the cefazolin group (Ceftriaxone, Cefazolin, etc.). They are usually prescribed for serious diseases, such as pneumonia. In case of ENT diseases, preparations for early pregnancy are prescribed for topical use whenever possible. For example, the drug Bioparox, it can be safely applied at any time.

In the second half of carrying a baby antibiotics options that can be used at this time, much more, however, they should be appointed only by a leading expert.

Antibiotics prohibited during pregnancy.

  • Tetracycline, doxycycline, since they have a toxic effect on the liver of the fetus, as well as accumulate in the bones.
  • Ciprofloxacin, Nolitsin, Tsiprolet - have a damaging effect on the joints of the fetus, and at any stage of pregnancy.
  • Furagin, Furamag, Ersefuril - in general, a negative impact on the fetus.
  • Levomitsetin and drugs, in which it is present, because it affects the baby's bone marrow, violates the process of blood formation.
  • Dioxidine - provokes the emergence of various mutations and abnormalities in the development of the child.
    Biseptol - zamilaet growth and development of the baby, significantly increases the risk of congenital anomalies.

Antibiotics and conception.
Very often there are situations where women were unknowingly treated with antibiotics, being in the position. How to be in this situation? Could this somehow hurt the baby? If the drug used belongs to a safe group, then the effect on the fetus, it will either have or not. If the drug was from the group prohibited during childbearing, then in the early stages it could all end in miscarriage, or the drug could provoke a missed abortion.

In the first case, there is only one way out: it is necessary to stop taking the antibiotic and wait. With a negative effect of the drug, a miscarriage will occur, but if the fetus survives, then, in most cases, it will continue to develop without deviations.

To detect a missed abortion, it is necessary to perform a blood test for hCG, and several times. The same results or low rates will be evidence of the cessation of fetal development. Another criterion is vaginal ultrasound for less than four weeks.

Hurry to do an abortion immediately, for fear of abnormalities in the development of the baby, is not worth it. After all, if there was a negative effect of the drug, the embryo in most cases dies. Malformations usually develop on the background of the impact of harmful at later stages in the period of growth of organs.

When planning a pregnancy, it is worth refusing to take any medications at all, to lead a healthy lifestyle, to engage in light sports.

Use of the drug "Cefazolin" during pregnancy

Synthetic first-generation antibiotic has a wide spectrum of action. His appointment is shown in the case when it is impossible to quickly determine the cause of the deterioration of health.

In case of allergy or individual intolerance, the use of analogues is allowed. These include "Penicillin" and the class of sulfonamides.

As mentioned earlier, the appropriateness of the appointment of each medicinal product is determined by the physician.

Cefazolin has a wide range of effects.

Due to the content in the preparation of sodium salts, its use is justified for the treatment of the following conditions:

  • Respiratory diseases,
  • The inflammatory process in the area of ​​the heart membrane,
  • Blood poisoning,
  • Skin diseases triggered by an infectious pathogen,
  • Sepsis,
  • Peritonitis,
  • Infectious processes on the background of surgery or a burn,
  • Venereal diseases,
  • The inflammatory process in the pelvic area,
  • Infectious inflammatory process of bones and joints.

The use of broad-spectrum antibiotics during pregnancy is due to pronounced clinical indications. The last word always remains for the doctor. His task is to determine how the resulting infection threatens the health of the mother and child.

Contra indications of Cefazolin medication: injections during pregnancy

The efficacy of the drug is determined on the basis of the ratio of the intended benefit and the potential harm. If the scales are outweighed in a negative direction, it is necessary to choose other antibiotics. Not the last role in the decision to abandon the use of the drug "Cefazolin" play contraindications. Allergic reactions in any form and convulsions take the first place on this list.

It does not matter how long ago there were such ailments. If there is a mention of this in the medical record, it is not allowed to prescribe the drug.

Cefazolin has contraindications - allergic reactions in any form and convulsions

Other contraindications are as follows:

  • Anorexia,
  • Jaundice,
  • Anemia,
  • Marked by an increased level of sugar in urine,
  • Pathological changes in the kidneys,
  • Violation of acid-base balance,
  • Dysbacteriosis
  • Stomatitis in any form,
  • A sharp decrease in leukocyte count,
  • There are inflammatory processes after intravenous injection,
  • Significant increase in platelet count
  • Fungal inflammation,
  • Lower abdominal pain
  • Attacks of vomiting and nausea.

The above list of contraindications indicates the need for a preliminary survey. His goal - to determine the feasibility of the drug. In case of even minor doubts, the doctor must choose another drug.

Injection of the drug "Cefazolin" during pregnancy: 2 trimester

Substances contained in the product inhibit the growth and reproduction of bacteria that do not form bacteria spores. This means that its use for the treatment of fungal infections does not make sense.

Another feature manifests itself depending on the duration of pregnancy. During the second trimester, the doctor may apply various injections that have no contraindications.

If the source of the problem has not been identified, then Cefazolin is assigned.

Injection of medication during pregnancy can not exceed 5 days

The features of its application at this stage are as follows:

  • The maximum duration of a therapeutic course is no more than 5 days,
  • Does not help with high fever and cough,
  • It makes no sense to use for the treatment of any form of SARS.

As soon as the second trimester began, the doctor begins to use a wide spectrum of drugs with jewel precision. Only having in the hands of the data of the survey, the appointment is allowed. The main thing is to choose the right medicine. Fungal, infectious and bacterial pathogens require a different approach.

Do injections of the drug "Cefazolin" during pregnancy: 3 trimester

Approaching childbirth significantly narrows the arsenal of possible means. Even a minor medical error provokes irreversible consequences. If the mother was diagnosed with the disease at this time, the doctor focuses on the severity of clinical manifestations.

With a slight deterioration in health, it is recommended to refuse injection at all. No need to once again risk the health of the mother and child.

If it is impossible to refuse, then in this case the dosage and duration of the therapeutic course is selected individually. As the reviews show, it is possible to remove the peak of the disease within 4 days.

With a slight deterioration in health, it is recommended to completely abandon the injection.

The doctor's actions depend on a number of factors:

  • You can not use the drug if the pregnancy is complicated by chronic diseases,
  • The presence of prerequisites for caesarean section, says a similar prohibition,
  • Course duration no more than 3 days.

Is it possible to "Cefazolin" during pregnancy (video)

Use during pregnancy of a wide range of drugs is strictly under the supervision of a physician. In the case when it is not possible to quickly determine the cause of the deterioration of health, Cefazolin is used. Its dosage and duration of the therapeutic course depends on the duration of the pregnancy and the results of the survey.

Antibiotic cefazolin at 26 weeks of pregnancy can be set? when nasal congestion does not pass a cold (

The temperature is? Nasal swabs passed on the microflora? Why an antibiotic?

In Latin, this medicine is called Cefazolin. The antibiotic Cefazolin during pregnancy, the reviews of specialists about its use are widely known and are used extremely rarely.

No way. forget you about antibiotics is no worse for the body

With a cold, and especially during pregnancy, antibiotics should not be used at all. There are folk remedies that warm the feet in a coniferous bath in a basin at a moderately hot temperature, using a thermos effect, and drink St. John's wort with mint oregano and honey. Procedure one-time in the room warm removable linen

Can cefazolin be used in the first trimester of pregnancy? I got sick

Make another natural medicine - 2 liters of boiled water, half a lemon, 2 tablespoons of honey, ginger root 3-4 cm, grate. Insist half an hour and drink like tea. Tasty and perfectly relieves colds and flu. And most importantly the child does not harm. All vitamins.

The use of Cefazolin in pregnancy in the form of injections and as an antibiotic is not beyond the scope of this rule. If you need drug treatment during breastfeeding, then breastfeeding is completely canceled.

It is impossible
it is better not to take anything at all in 1 trimes.

How can Cefazolin antibiotics affect the fetus at 1-2 weeks of pregnancy if I took it for only one day?

No at this time is not dangerous

Cefazolin use during pregnancy. During pregnancy, any antibiotics, including Cefazolin, should be taken strictly according to the indications and only when the health of the mother is more important for the potential risk to the fetus.

Pregnancy 1-2 weeks. I do not know this term.

From the official manufacturer's instructions, “Cefazolin has the ability to penetrate the placental barrier. Cefazolin can be used during pregnancy only for absolute reasons. If the administration of Cefazolin is prescribed during pregnancy, it is necessary to carefully evaluate the degree of its beneficial effects in comparison with the risk. As with other beta-lactam antibiotics, there are no data on the toxic effects of Cefazolin on the embryo or fetus.

Http://gynecology.popmed.ru/pregnancy/pregnancy_1term/ I just read this hour on the first trimester of pregnancy .. something may be useful .. I don’t know this antibiotic))

Absolutely agree with Irina. Nature is not stupid and insured against us. Главное, дальше берегите себя и будущего ребенка.

Не оказывают вредного действия на организм беременной женщины и плода антибиотики пенициллинового ряда ( например, Оксациллин, Ампициллин ), цефалоспорины ( например, Цефазолин ) и некоторые макролиды ( например, Эритромицин, Азитромицин ). Their experts prefer others in the treatment of infectious processes in pregnant women.

All antibiotics during pregnancy can be divided into three groups 1 Forbidden completely, due to the proven toxic effect on the fetus In pregnancy, are eliminated by the kidneys at an accelerated rate. Cefalosporins cefazolin, cefalexin, ceftriaxone, cefuroxime.

Did you drink cefazolin and metronidazole antibiotics during pregnancy? It just happened to me? and what to do?

No, they prescribed amoxycycline, and even then for a long time.

Cefazolin and alcohol. Contraindications. When pregnancy. Pharmacodynamics. Cefazolin is a semi-synthetic antibiotic of the first generation with a wide range of action, which has a bactericidal effect on gram-positive and.

Nothing. healthy children were born. I took all 3 pregnancies. although you need to take lactobacillus at the same time.

The question is serious. need to talk with a doctor. if the term is not large, then the rule of all or nothing should work. if the pregnancy continues, it should not have worked. as for the second drug, the doctor told me that it should not be taken during pregnancy, and if you drink it, you should protect yourself well. I don’t know anything about the first one. the main thing to believe. Now my sister is not knowing that she is pregnant and has done a flute and the massage of the lumbar section is serious, which provokes a miscarriage and nothing))))) soon give birth.

Not what did not drink .. although prescribed!

Antibiotics are a terrible thing, and they need to be taken only in emergency cases. The fourth-generation cefazolin antibiotic, after taking this antibiotic, other less weak antibiotics will not help. And during pregnancy it is undesirable to take antibiotics. They have a negative effect on the body of the mother and baby. And metronidazole is not an antibiotic, but an antibacterial agent. And in general, I want to say that any medication should be taken only as prescribed by a specialist doctor and never self-medicate.

No, you better tell the doctor. Good luck!

3 Than to plant. 4 Cefazolin in pregnancy. The antibiotic Cefazolin is outdated and practically does not find use in global medical practice.

I was prescribed by a doctor for a long time (or rather, we waited for the 8th month of pregnancy to start taking) and it seems like nothing.

Is it possible to prick cef 3 during pregnancy for 24 weeks? What could be the consequences?

This is in the sense of a cefazolin antibiotic, judging by the instructions, admission to pregnancy is acceptable, but according to strict vital indications, since adequate and strictly controlled studies have not been conducted.

Cephalosporins Cefazolin, Cefatoxime macrolides Erythromycin, Azithromycin. Antibiotics used during pregnancy, in the future can be assigned to a woman and during breastfeeding.

Is it possible for a nursing mother to prick ficosoline?

A nursing mother is not what is not possible, but the question is not that it’s here or you should stop feeding and prick or not, it all depends on the situation and illness.

If a patient is given a drip, the antibiotic is usually diluted with glucose, and sodium chloride is used only in rare cases. It is dangerous to use Cefazolin in pregnancy and lactation without a doctor's supervision.

Cefazolin is the most "safe" antibiotic for pregnant and lactating.

"Use during pregnancy and lactation is justified only in cases where the expected benefit to the mother outweighs the potential risk to the fetus or child"

In the hospital after childbirth, they just don’t prick and still say to breastfeed. and no one died

Check with an experienced pediatrician, and then if there is a risk, look at the date of withdrawal of the drug in anatatia and feed the child with mixtures for this time. In general, there are still doctors who have been studying for 6 years. to treat why not ask an experienced doctor

Is it possible to prick antibiotics in early pregnancy? for example Cefazolin

In principle, you can, if you have already tried everything popular.

Cefazolin is a first generation cefalosporin antibiotic. It has a bactericidal effect, actively influences many pathogens. Interaction with alcohol. Overdose. Cefazolin use during pregnancy and lactation.

Take better topical spray hexaral; it is not absorbed. and rinsing with salt, in order to rot the inflammation, and it went out on the edge.

This is an extreme case, antibiotics have teratogenic activity, but if the doctor prescribed, then it is possible and possible to pierce. Watching what the diagnosis. For angina, local antibiotics are better than general effects.

The child is more important, ask your doctor than to be treated.

At the reception in the antenatal clinic with a detailed story. and take the direction to loriku.
. Cefazolin is not the best choice (((

Contraindications: Pregnancy. Here is the answer to your question.

Features of antibiotics in the early period. Indications for use of antibiotics in early pregnancy. Cefazolines prescribed in the treatment of serious diseases such as, for example, bilateral pneumonia.

For the sake of the future baby do not self-medicate. Contact a specialist in person.
Otitis can be a complication of 4-6 days after the onset of the underlying disease.

How do antibiotics affect pregnancy? I did not know took cefazolin.

I don’t know how they affect pregnancy, but I know that it is a very strong antibiotic.

Home Pregnancy Articles Antibiotics during pregnancy. Cephalosporins cefazolin, ceftriaxone, cefepime all injections, suprax tablets, etc.

A child may die very badly or it may become incomplete.

In critical conditions, it is prescribed, but it is better not to risk it. Pregnancy is a contraindication to the use of this antibiotic.
About self
About all the intricacies of pregnancy

Antibiotic and pregnancy. During cefazolin injections with novocaine, I became pregnant, what are the consequences and what to do?

And where did it get you so much with cefazolin and novocaine that you got pregnant? )))))))))

Antibiotics during early pregnancy, in the first month and in the first days are prescribed with great caution, if there is no way out, and the expected benefits outweigh the possible risk, the doctor may prescribe a pregnant cefazolin antibiotics.

Do not worry, the laying of organs occurs in the second trimester of pregnancy.

In the first 4 weeks of pregnancy, there is no connection between the embryo and the mother through blood. But after 4 weeks - do not recommend antibiotics!

Well they removed inflammation .. I’m pregnant, naturally giving birth - cefosalin with novocaine is not a sperm cell, from which you can get pregnant, probably get pregnant from a man.

Everything is good. nothing special is needed and there will be no consequences

The wife at the initial stage of pregnancy, not knowing that she was pregnant, underwent a ten-day course of antibiotics Cefazolin.

Only an obstetrician-gynecologist can answer, but not 100%. Listen to the opinions of several doctors! And if allowed to give birth, then be observed by a good doctor!

Antibiotics during pregnancy are used only as prescribed by a doctor! The effect of Cefazolin on the fetus. At the first stage of pregnancy, I took cefazolin intravenously, how will this affect the fetus?

No one will say 100%. Talk to doctors and pharmacists.

I was injected with cefazonin but at the final stage - then the placenta was thick and I didn’t seem to miss any rubbish, but I still had a wild experience, the child still had dysbacteriosis and a skin problem at birth, but then was cured. the trouble is that the doctors say that you can prick - other people's patients - but they don’t prick their relatives and daughters - they are treated with traditional methods. like this..

The instructions for cefazolin in Russian are written: CONTRAINDICATIONS - PREGNANCY. Antibiotic, antibiotic strife. Go to the doctor before it's too late!

Who was Cefazolin in pregnancy? How long can it prick. I kolyat 2.5 weeks. Is it harmful?

Chet many you prick. But in general, antibiotics are prescribed as a last resort. Once you have prescribed such a long treatment, it means it is necessary.

Use for the treatment of angina, sepsis and other infections in adults, children, as well as during pregnancy and lactation. Cefazolin - 1st generation cephalosporin antibiotic. Bactericidal effect. Possesses a wide range of antimicrobial action.

Got to the hospital for 19-20 weeks with odontogenic phlegmon. Pricked 9 days. Upon admission to the hospital, the gynecologist naturally examined the cefazolin approved, because although it penetrates the placental barrier, it does not harm the fetus.

Cefazolin prescribed with pregnancy with caution, it is an antibiotic and of course it is harmful, especially 2.5 weeks, what is your period? and what can be treated with a 20-day course of antibiotics?

I was injected for 10 days, then ceftriaxone was prescribed, it was stronger, sat on antibiotics for a month, there was bilateral pneumonia. The gestational age was 12 weeks, the child was born a patient with developmental disabilities.

I pricked 7 days.

Someone had to take it during an intensive care period, including antibiotics? I had to, I worry now.

It was treated! On April 9, my duplicate antibiotics will be 25 years old!

I have bacteria in my urine, and I also found protein, and now leukocytes, herbs and canephron do not help, it just got worse, the doctor said that it is necessary to prick cefazolin, because it is an antibiotic and not weak. very worried, pregnancy is very welcome and welcome.

Everything will be fine. the main thing - do not worry. I took antibiotics for 32 weeks, also with pyelonephritis. There were no places in the hospital, I saw the house of Amoxiclav. the infection must be treated, otherwise during the birth you infect the fetus. after treatment, I highly recommend you to drink canephron and phytolysin (only it is very nasty, but it helps well) to thoroughly wash the kidneys. but be sure to check with the doctor. do not be ill! healthy baby you! my already almost 4 months.

Yes, there was a very intensive therapy. then I didn’t even breastfeed (thank God), but the baby is absolutely healthy!

I was treated during the whole pregnancy, I just hurt without ceasing
I have a bunch of chronic diseases, including pyelonephritis.
several strong colds were for pregnancy, took antibiotics
Now the child is 4 years old and thank God everything is fine.

Heal and do not worry! I also have a poor girlfriend with kidneys. All of the berness once a month was in the hospital, strong antibiotics were pricked, and they were already terrified at the hospital. but everything is fine. she has such a clever son))

I have experienced it myself, it is better to be treated and to quickly overcome the disease, than not to be treated - to wait and get complications on the baby because of their colds. And of course it's better not to get sick at all !! ! Get well and no longer get sick!

What antibiotics are possible during pregnancy. 1. Erythromycin Rovamycin, Vilprafen crosses the placenta in small concentrations. 2. Cephalosporins Cefelim, Cefotaxime, Cefixime, Ceftriaxone, Cefalexin, Cefazolin.

I was treated. I was cut out appendicitis during pregnancy. And after the operation, I got into the pathology department of pregnant women with kidneys and liver, and they were injected with a very strong antibiotic ceftriaxone 2 times a day for 10 days. In addition, they still injected antibiotics, put droppers and I drank pills. Now I have 29-30 weeks and everything is in order. In June, there will be a daughter. So everything will be fine, do not worry.

The child is constantly sick .. Who is to blame?

Blame natural selection. the weak in nature are dying

What antibiotics are possible during pregnancy? All the drugs in this list can be used during the child's pregnancy. During pregnancy, cephazolin, ceftriaxone, cefalexin are rapidly excreted by the kidneys.

Reread it yourself

Feed the child vitamins.

If you are sick often, it seems to me that immunity is weak.

No one is to blame, the usual adaptation, someone faster, someone longer snotting, etc., strengthen the immune system, well, still have patience, but not the guilty look

Pharmacological action of Cefazolin. The drug is a cephalosporin antibiotic with a bactericidal effect. Use during pregnancy and lactation. Cefazolin is able to overcome the placental barrier.

It was necessary to temper the summer, swim, barefoot run. And the girlfriend drive nasty broom.

It's nobody's fault. The body of the child is so weak, just that immediately snot ..

So he does not climate there. in the sense of - not like, you need to understand what the problem is. Around us are full of all sorts of bacteria, but as long as the immunity is strong (and not only at the physical level), nothing will stick. I was convinced of this myself when I fell down with the flu simply because I was tired of working.

Heredity + parents (did not prepare the child for kindergarten).

Indications for use. The question and the use of antibiotics during pregnancy are decided only by a doctor. The safe penicillin amoxiclav, amoxicillin, ampicillin cefalosporins cefazolin, ceftriaxone, cefalexin, cefixime, cefuroxime, cefoperazone, ceftazidime.

An educator friend told me: as soon as she was bored with the noise, din in the group and other fuss with the children, she opened the window, the next day the subgroups went to the hospital, and for a week or two they could sit quietly

Child immunity is an interesting thing. It cumulatively consists of many important components. The most important of these is the combination of the mother and father genes. And Nature at the stage of dating itself gives rise to both in a man and a woman at the level of chemical odors an attraction to each other or, on the contrary, rejection. That is why some people are physically appealing to us, while others are unpleasant. Thus, Nature protects against "wrong connections" so that children with a bad mix of genes are not born. Further, the child's pregnancy is connected to the health, namely its usefulness. Premature babies do not receive immunity. Then breastfeeding is extremely important, since maternal antibodies of her immunity come into the baby’s body from the mother’s milk. That is why feeding mixtures instead of breast milk is fraught with consequences for future health. And finally, all kinds of vaccinations improve and protect the child from serious diseases.
At the same time, at a young age, it is considered normal, if a baby snotty and catches cold up to 7 times a year, because its immunity is still trained in modern types of viruses and bacteria. As Onishchenko said: "Children still do not have ACQUIRED immunity." Much worse, if the child is not sick, it means that his immunity is all the same, and the body is like a garbage dump, in which all germs accumulate.

My dear, you have given birth to a child yourself. Do not give them to indifferent people, rejoice that you have this child. And if you want to work, hire a nanny (or grandmother, but for 3 days she should be free) and work for yourself. When the child himself does not feel discomfort, you need a neurologist.

No wonder, the child snatched the infection and brought it home; now you will be sick in a circle.
Immediately I give advice, because he himself went through this: if the snot is transparent - a virus cell, antibiotics are useless, if the green ones are worse, an infection, then go to the pediatrician and more than one, so as not to be mistaken, do the hardening yourself: with an icy towel (but it’s healthy Naturally) wipe your feet, then rub to hot terry and sleep, for six months - there will be a bogatyr or a girl for a vydane))) also would not hurt yourself.
P.S. Try not to bring up cefazolin - then other antibiotics will not be taken.

You just have weak immunity, who is to blame? Nobody, of course. You just need to make an appointment with an immunologist to advise you how to strengthen the immune system. We were told, before going to kindergarten, to lubricate the mucous membrane of the nose with Viferon gel, it is antiviral, it does not burn the mucosa, so it strengthens the immunity of the child. I also lubricate the mucous membrane for prevention. Think about the topic of hardening, although, to be honest, we ourselves have not reached this point yet. We constantly drink vitamins, I do not believe that there is enough of them in fruits and vegetables. Separately, we give vitamin D, it also strengthens the immune system. I constantly air the room to change the air. With the heating season, the air in the apartment is very dry, this is also bad for our immunity. Constant wet cleaning, I also turn on the humidifier, if it is not there, you can simply splash it with a spray bottle several times a day. Do not forget that we need walks every day. It is possible for the prevention of wild rose brew, give to drink, there is a sea of ​​vitamins. You can still cook the juice from cranberries and lingonberries. Go to the immunologist, there will be more advice.

Antibiotic Cefazolin and features of its use. Cefazolin is an antibacterial agent of the 1st generation cephalosporins group. Early pregnancy. What helps from phlegm. Lugol in angina use and

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The cat is pregnant and she began to have abundant purulent vaginal discharge. What are antibiotics stabbing?

Which vet will prescribe?

How does the antibiotic cefazolin injections affect the fetus in the second trimester of pregnancy? SPRING 12.03.2010 16 27. From the official manufacturer's instructions, Cefazolin has the ability to penetrate the placental barrier.

What the vet will appoint after you take the cat to him.

Cycloferon and cefazolin

Very incorrectly asked a question. FIRST TIME OF PREGNANCY IS UNKNOWN. Secondly, there are no results of ultrasound. Is there any pregnancy in general? It looks like a purulent pyometra.In this case, the decision on complex treatment. Answer your question without a cat inspection is impossible. For all purulent processes, antibiotics of 4 generations with a wide spectrum of action are used for example. ceftriaxone.

It is necessary to do an ultrasound and then decide whether to chop antibiotics or remove the entire uterus with the fruits in order to save the cat's life.

Excuse me, but it looks like the cat has endometritis and there can be no talk about the birth of kittens. You would have to go to the veterinarian, but to consult, you may urgently need to sterilize the animal. Kohl different antibiotics, you can not cure the animal, but simply weaken the body.

Taking antibiotics during pregnancy and tragic consequences. These include Cefazolin, Cefotaxime, Cevthriaxone, Supraks, etc. The group of macrolides is relatively safe.

Are you sure you are pregnant? More on purulent pyometra similar.

Do not let the cat on the street anymore. And in fact, carry to the doctor despite the pregnancy.

No prick, will not help. The operation is necessary, and so die.

How to cure an ovarian cyst, without surgery?

The ovarian cyst is a benign hollow ovary formation with liquid contents.
Ovarian cyst is usually observed in women under 50 years of age. Often they are asymptomatic. The main diagnostic method is ultrasound, including a vaginal sensor, laparoscopy and vaginal examination.
There are different types of ovarian cysts and their causes are different.
Functional ovarian cysts (corpus luteum cyst and follicular cyst) are due to hormonal imbalance. With proper treatment (usually oral contraceptives are used for this), such cysts resolve themselves. However, if they do not disappear after 3 months, they resort to surgical treatment. The remaining cysts, whatever their origin (endometrioid, dermoid - abnormal embryonic bookmark, etc.) are subject to mandatory surgical treatment, because they may malignant.
After removal of an ovarian cyst, normal pregnancy and childbirth are possible. In the presence of functional cysts, normalization of hormonal levels is necessary.
An ovarian cyst is a retention formation and belongs to tumor-like processes, that is, in fact, it is not a true tumor. Hence, whenever possible, its treatment is carried out non-operatively, resorting to surgery only in the event of complications, such as torsion of cysts.
Katyusha, and help baths. She was treated. !
For local treatment (local baths) fitozbory are used:
birch leaf, borovaya uterus, leaf cuffs, tansy flowers, blueberry leaf - equally
geranium grass, oak bark, wormwood grass, chamomile flowers, tricolor violet grass, equally
snake mountaineer root, calendula flowers, plantain leaf, agrimony herb, yarrow herb, bird cherry fruit, thyme herb - equally
Althea root, wormwood grass, aspen bark - equally
Badana root, fireweed leaf, lavender grass, tricolor violet grass - equally
viburnum bark, flax seeds, clover flowers, horsetail grass, celandine grass - equally
birch leaf, nettle grass, mother-and-stepmother leaf, juniper fruits, bird cherry fruits - equally
Angelica root, Hypericum grass, calendula flowers, meadowsweet flowers, mint grass, dandelion root, blueberry leaf - equally
clover grass, mint grass, eucalyptus leaf - equally
elecampane root, wormwood grass, licorice root - equally
Infusions for local trays are prepared as follows: 2 tablespoons of minced in a meat grinder or in a coffee grinder collection pour 2 tablespoons of boiling water, heated in a boiling water bath in a sealed container for 15-20 minutes, insist one hour, drain. Bring boiled water to a volume of 2 liters. The resulting infusion is used for sedentary baths, the duration of the procedure is 15-20 minutes, 1-2 times a day. Course 10-12 baths.
Improvement with herbal medicine occurs after 2-3 weeks of regular use of herbs. However, lasting effect can be achieved only in the case of prolonged and regular use of herbs (within 8-12 months or more). Before you take one or another collection, it is desirable to familiarize yourself with the contraindications to herbs that are part of this collection in herbalist.

If antibiotic therapy is needed at an early stage of pregnancy, the doctor, evaluating the pros and cons, may prescribe the future mom for the cefazolin group antibiotics Ceftriaxone, Cefazolin, etc. . They are usually prescribed for serious diseases, such as pneumonia.

Cystic ovary called abdominal formation, filled with fluid. In gynecological practice, there are quite a lot of pathological conditions, in the names of which the word “cyst” is found: cyst of the corpus luteum, follicular cyst, endometrioid cyst, dermoid cyst, paraovarial cyst, etc. What kind of cyst are you going to treat? A follicular cyst, for example, does not require treatment at all, and an ovarian cystoma may turn out to be cancer, therefore it requires unambiguous surgical treatment.

Everyone is so smart, especially when they download from the Internet that they don’t know. I also have an ovarian cyst. I do ultrasound once a year, watch it. The main thing is that the size does not increase. She can dissolve herself. And if it starts to grow, then only delete.

I had it. Contraceptive pills were first prescribed, and a year later she underwent laser therapy in combination with antibiotics. long ago it was already plain and I do not remember what I saw. but the point is that the cysts are gone. find a good gynecologist and you will be happy! ! it is treated and quickly enough, it resolves over time, the main thing is to correctly assign a course of treatment.

With exacerbation of the disease, you can puncture 5-7 days, in the morning and in the evening cefazolin injections are diluted with novocaine. Cefazolin is a very strong antibiotic that cures any inflammation in the body. These injections are usually prescribed in the hospital, but at home you can prick. After a course of injections, it is desirable to drink Bifidumbacterin, and 1 tablet of flucostat from thrush. To prevent relapse, it is good to drink a decoction of onion peel, boil it for 5 minutes, a handful for 2 glasses of water, and drink it during the day after eating. There are a lot of vitamin C in onion peel and this is a natural antibiotic. Also, the broth is good to drink with inflammation of the bladder. Cysts can be cured forever, and without surgery.

Here you can find the right doctor who will help you to cure an ovarian cyst http://docdoc.ru/?pid=5531

Traditionally, antibacterial drugs are divided into natural antibiotics, for example, Penicillin, semi-synthetic, for example, Amoxicillin or Cefazolin, which affects the antibiotic during pregnancy. How do antibiotics affect the fetus?

Candles help very well with celandine-10 days-break-10 days and to see a doctor!

I help in the treatment of ovarian cysts, tumors (non-cancerous). I fly conspiracies. The result in the treatment of cysts, ovaries, tumors has been repeatedly and successfully tested on relatives, acquaintances, including themselves. Two years ago there was an operable cyst of both ovaries. Rolled everything myself. The gynecologist was surprised for a long time. There are no "fetishes" like magic salons, the price tag and the price, too. Pay or give as much as you see fit. I work at home. Write - be sure to answer: [email protected]

What can postpartum jaundice affect in a newborn?

S top in the history of perebolet.

Cefazolin is a first-generation cephalosporin antibiotic that is a semi-synthetic antimicrobial. The drug is not recommended for use in the following cases during pregnancy and breastfeeding.

On the liver. MORE SUN.

If she passed quickly - 2-3 days, then this is normal.
It happens to everyone.
If more - need to be observed and treated.
And doctors and homeopaths.
And what could be later ..
I do not know, you can not make a diagnosis on this issue.

No matter what, calm down. and do not listen to anyone .. and then you can go crazy.

Jaundice or jaundice? If it is a yellow one, then there is nothing terrible about it, we also had it.

Jalous she only called and has no relation to hepatitis. This bilirubin, which is formed when the breakdown of excess hemoglobin. Nothing wrong. Nothing will affect. If you are worried, consult a doctor. All the best!

Antibiotics during pregnancy why not and when you can What antibiotics are permitted during pregnancy? Indications for taking antibiotics during pregnancy Cefazolin is prescribed for extremely strict indications, and then from the second trimester.

My baby had a little yellow one, lemon) But there was no consequence, thank God. The doctor explained that there is no need to worry, for many it happens and passes without consequences. Everything will be fine, listen to the doctor! Good luck! And health.

She will pass.
give the child more simple water
and more often be in the sun.

No matter what. The main thing in the hospital under the quartz lie 10 hours and all. They have something in their skin that is produced from quartz and after that everything passes. Do not be afraid. My daughter had a yellow one, and so many children too.

Esli zameteli chto vash rebenok stanovitsia zeltim obratitis k vrachy vrachy ..

Postpartum jaundice is normal, because in newborns och. high hemoglobin. While it is normalized, the red bodies disintegrate, it turns out bilirubin.

There are many diseases when antibiotics during pregnancy are a necessary measure. These include .2-3. Cefazolin. For the treatment of urinary tract infections, skin, bone system, joints, osteomyelitis.

We had no effect on anything.

Pilonephritis during pregnancy

In fact, it is necessary to choose the lesser evil - edema and inflammation of the kidneys - not at all good during pregnancy, especially in the later periods, the antibiotic is in fact not such and evil and will not affect the already formed baby.

All antibiotics during pregnancy can be divided into three groups 1 Forbidden completely, due to the proven toxic effect on the fetus In pregnancy, are eliminated by the kidneys at an accelerated rate. Cefalosporins cefazolin, cefalexin, ceftriaxone, cefuroxime.

I also had pilonephritis during pregnancy, but antibiotics were not prescribed. Saw kidney tea constantly

I had . during both pregnancies ... and that's what I say ... if an antibiotic is prescribed - this is not the worst thing in life ... but if during your pregnancy your kidneys die completely from non-treatment - I think the baby and you will not be better ...
Flemoksin, amoxiclav even give babies, not so brutal antibiotics
Of course it is good that weeds help you, but you shouldn’t resist taking sensitive antibiotics.

And the protein in the urine is?

Pyelonephritis is either there or not. If he does not show himself, it does not mean that everything is in order. The doctor has appointed me "Kanefron", I read the instructions, everything is on grass. Ask, maybe he will help you. A healthy baby is more important.

Consult a few experts.
I was also given this diagnosis, I also saw that you did.
And a month later I gave birth, and after giving birth, I went to an ultrasound scan and tested, nothing happened ..

Antibiotics during pregnancy. Cefazolin. The topic in the section Pregnancy and medications, created by LinaT, Jul 17, 2012. Hello! I want to share my experience with antibiotics during pregnancy. In the third trimester, I strongly.

I have pyelonephritis doubling of the right kidney + dropsy, and drying of the left kidney. dysplasia.
1st daughter gave birth 2.5 years ago, the second 2 months. backwards the kidneys are turned into a sieve. although not disturbed not during ber-ty, not during childbirth, nor after. Both times she gave birth herself

You have a long time, do not be afraid to take drugs. You will be better off. I was pregnant with pyelonephritis in nephrology for a week. Pricked cefazolin (antibiotic), drank canephron, kidney teas and everything went quickly. It is unlikely that the doctor will prescribe a horse dose of antibiotic to you.

My dear, drink what they say. God forbid in preeclampsia goes, but it is rapidly developing. I am at 27 weeks ber child deprived because of this.

I had a friend. I spent 2 weeks in the hospital, the whole pregnancy was not the diagnosis. after childbirth on the ultrasound went, a stone in one kidney. They said you need to delete

I also saw "Kanefron" and watched the liquid drunk

Cefazolin - 1st generation cephalosporin antibiotic. Bactericidal effect. Possesses a wide range of antimicrobic action. Application at pregnancy and feeding by a breast. The drug is contraindicated in pregnancy.

They are usually treated with antibiotics, because the bacteria are not killed by simple pills. But pregnant women I don’t know how they are being treated, they have put my friend in the hospital and she has given birth later on and in pathology

Antibiotics during pregnancy

Well, if you do not have a sore throat, you cannot stop drinking. I drank antibiotic during pregnancy I had bronchitis

Cefazolin is a semi-synthetic cephalosporin antibiotic of the first generation of a broad-spectrum for parenteral use. Cefazolin is often prescribed during pregnancy.

The lack of temperature does not mean that the disease has stopped. As if the complications did not begin. If in doubt whether to drink - consult with another doctor.
As if I had a sore throat, I crawled like a half-dead fly for two weeks, it did not heal until antibiotics were drunk off. And this is all without temperature at all.

I drank an antibiotic. Everything is good. It is better to drink. Especially if you have not the first trimester.

And what is the diagnosis? In some diseases, it is quite possible to do without an antibiotic. But temperature does not play a decisive role, sometimes it may not be at all, and an antibiotic is needed. If nothing serious, the usual ORZ / ARVI, then it is quite possible to do without it.

I think you need to drink.

I drank two rush, all is well. But if I’ve listened to doctors for pregnancy I didn’t drink twice, but four

Permission to use cefazolin and its analogues during pregnancy is yes, while lactation is yes. Based on all the information provided, practicing midwives conclude that, if indicated, the use of cefazolin in pregnancy is acceptable risk.

Diseases and conditions requiring antibiotic therapy

The doctor prescribes treatment based on the clinical guidelines of the Ministry of Health. Sometimes antibiotics are the main drug in the protocol, but there are conditions in which their prophylactic administration is necessary.

Antibacterial therapy during pregnancy is carried out in the following situations:

  • lesion of the genital organs: bacterial vaginosis, mycoplasmosis, trichomoniasis, ureaplasmosis, chlamydia, gonorrhea, syphilis,
  • pathologies of the hepatobiliary system: acute fatty degeneration, HELLP syndrome, cholecystitis,
  • respiratory diseases: pneumonia, bronchitis, antritis,
  • pathologies of the urinary tract: cystitis, pyelonephritis, single kidney,
  • infectious lesions of the digestive tract,
  • in case of miscarriage due to infection,
  • severe injuries, purulent wounds.

Also, antibiotics are prescribed after surgical interventions during pregnancy, after delivery by cesarean section and infectious complications of the postpartum period. Their choice is based on safety for the woman and the newborn child who is on breastfeeding.

Drug hazard groups

All drugs undergo a lot of research, the purpose of which is not only to establish their effectiveness, but also to reveal how dangerous they are for pregnant women and the developing child. After laboratory and clinical trials, they are assigned a specific hazard category. So share drugs:

  • Group A - passed all the necessary tests. According to their results, no danger to the fetus was revealed.
  • Groups B - includes two types of drugs. The first of them was tested on animals, as a result of which no negative effect on intrauterine development was detected. The second was tested on animals and pregnant women. In humans, no effect on the fetus was found, and in pregnant females, slight undesirable effects were detected.
  • Groups C were tested on animals, negative effects on the progeny being formed were revealed - toxic, teratogenic. Therefore, clinical trials in pregnant women were not conducted.
  • Group D - after the experiments and clinical trials, a negative effect on the fetus was recorded.
  • Groups X - have a very dangerous effect.

The first two groups of drugs can be used in the treatment of pregnant women, regardless of the period of gestation. The remaining three are prohibited for the treatment of pregnant women. The consequences of their use can lead to serious complications and pathologies on the part of the fetus.

Consequences of using antibiotics

Antibacterial drugs can harm the fetus, if they are prescribed from the list of prohibited use. But much depends on the period in which the therapy was carried out.

A woman does not always plan a pregnancy and knows about its occurrence. It may be in such a situation that the egg is already fertilized, but the time of menstruation has not yet come. Bacterial infection is treated with antibacterial agents. If you drink antibiotics before the delay, their choice does not have the same value as in the first days of pregnancy, which has already been confirmed. If you undergo a course of treatment, then the principle of "all or nothing." This means that the drug will either lead to serious developmental pathologies and miscarriage, or not affect the embryo.

Taking antibiotics in the first trimester of pregnancy is associated with serious complications. During this period, there is a laying of all organs, the formation of limbs, the neural tube. Any negative effects during the period of active cell division lead to the formation of congenital malformations:

  • absence of organ - aplasia,
  • underdeveloped organ or limb - hypoplasia,
  • change in normal shape or location,
  • the formation of additional holes, fistula.

Severe effects of antibiotics in certain groups during this period are due to an unformed placenta. After attachment to the wall of the uterus and up to 10-12 weeks of development, the fetus receives food directly from the endometrial microvessels. There is no filter system that will not let in harmful substances. Only an established placenta can protect the unborn child from the action of many toxic substances and microorganisms. Therefore, the necessary antibiotic therapy in the 2nd trimester is less dangerous.

But this does not mean that it is possible to carry out treatment with the same drugs as non-pregnant ones. The middle of gestation is the period of ripening of the fetus, its active growth and the formation of thinner structures. For example, bone tissue, nervous system, organ of vision and hearing.

On the other hand, infectious diseases that have been active in the 2nd and 3rd trimester are no less dangerous for the child. They can lead to the following complications:

  • premature birth,
  • low water and high water,
  • congenital infection
  • intrauterine growth retardation
  • antenatal death,
  • feto-placental insufficiency.

Therefore, leave untreated infection can not be. When choosing an antibiotic, the doctor is guided by the principle: the prevalence of benefit to the fetus over the risk of negative consequences.

What antibiotics can be taken pregnant?

They belong to three groups of drugs:

But despite the relative safety, treatment should be coordinated with the doctor. These medicines have other side effects that are not related to pregnancy:

  • Destroy the intestinal microflora, which leads to stool disorders - diarrhea or constipation, which are caused by intestinal dysbiosis.
  • The development of dyspeptic disorders: heartburn, stomach pain, nausea. On the background of pregnancy due to frequent digestive disorders in the stomach, its displacement by the growing uterus, these symptoms bother many women. And after a course of antibiotic therapy may increase.
  • Vaginal candidiasis is a frequent companion of pregnant women, treatment with antibacterial agents will disrupt the vaginal microflora and lead to an aggravation of the fungal infection.
  • Allergic reactions may occur, even if previously the treatment with the selected drug was not accompanied by such a side effect.

Safe antibiotics have certain indications and a spectrum of activity. Also in each group there are several representatives who are allowed in pregnant women. By the level of danger, they are classified as group B.

Penicillins

In the treatment of pregnant women use synthetic and semi-synthetic drugs: Amoxicillin, Ampicillin, Oxacillin.

Penicillin Group Antibiotics

Penicillins have a bactericidal effect, they lead to the death of microbes by blocking the synthesis of certain substances that are part of the bacterial cell wall. Penicillins are active against the following groups of microorganisms:

  • streptococci
  • staphylococcus,
  • enterococci,
  • listeria
  • neyserii
  • Clostridiums
  • corynebacterium.

But some microorganisms have learned to defend themselves from the effects of antibiotics. They produce a special enzyme that breaks down the active ingredient. Related to this is the development of drug resistance.

Oxacillin is an antibiotic to which resistance does not naturally develop. He is able to fight infection associated with the action of staphylococcus. But against other pathogens, it does not show pronounced activity. Therefore, its use is limited.

To prevent microorganisms from becoming resistant to drugs, protected penicillins have been developed. These drugs contain additional substances that do not allow microorganisms to destroy them. These drugs include Amoxicillin / Clavulanate (Amoxiclav), Amoxicillin / Sulbactam (Sultasin).

These drugs are allowed in the first trimester of pregnancy and in the later periods. Given the spectrum of activity, they are used to treat the following diseases:

  • respiratory tract infections: sinusitis, tonsillitis, bronchitis, pneumonia,
  • diseases of the urinary system: cystitis, pyelonephritis,
  • meningitis,
  • endocarditis,
  • salmonella,
  • infections of the skin and soft tissues
  • when preparing for surgery as a prophylaxis.

Due to the low activity of Oxacillin, it is used much less frequently than Amoxiclav or Sultasin. Indications for treatment are pneumonia, sepsis, endocarditis, infections of the skin, joints and bones.

Side effects from penicillin therapy can be the following:

  • dyspeptic disorders: nausea, abdominal pain, vomiting,
  • allergic reactions, and if an allergy developed to one of the representatives of this group, a similar reaction is possible to other representatives of penicillins,
  • decrease in hemoglobin,
  • electrolyte imbalance,
  • headache.

Unwanted effects often develop with prolonged use or use in large doses.

To combine penicillins with other medications should be carefully only after consulting a doctor. For example, with bronchitis, Fluimucil is often prescribed as an expectorant. Its active ingredient is acetylcysteine. With simultaneous use with ampicillin, their chemical interaction occurs, which leads to a decrease in the activity of two drugs.

Cephalosporins

This is the most extensive group of broad-spectrum antibiotics. According to the mechanism of action and activity against certain microorganisms, they are isolated in 4 generations. The smallest range of use of the first, the widest - the last.

Cephalosporins are structurally similar to penicillins, so there may be cases of cross-allergy in the presence of intolerance to an antibiotic from the same group.

Antibiotics group cephalosporins 3 generations

The first three generations of cephalosporins are used in the form of injections and medicines for oral administration. The latest generation is only in the form of a solution for injection. So:

  • Cefazolin belongs to the 1st generation. It is used only as an injection. Cefazolin's antibacterial activity is low. Infectious diseases caused by streptococci, some strains of staphylococcus, Escherichia coli can be treated. Can not be used to suppress pneumococci, enterobacter, slightly affect Shigella, Salmonella.
  • Generation 2 is represented by Cefuroxime and Cefaclor. The first is available in the form of a solution for injections and in the form of tablets. Whether it is possible to drink antibiotics from this group in the early stages of pregnancy, the doctor must decide. Their spectrum of antibacterial activity is not wide, so they will not help with every infectious disease.
  • Cefotaxime and Ceftriaxone belong to the 3rd generation, which are identical in their activity against staphylococci, streptococci, pneumococci, meningococci, gonococci and many others.
  • Cefepime belongs to the 4th generation, which is very similar in its characteristics to Ceftriaxone and Cefotaxime.

Pregnant women most often use the 3rd generation of cephalosporins. They are used in the following pathologies:

  • severe infections of the upper and lower respiratory tract,
  • infectious lesions of the pelvic organs,
  • sepsis,
  • meningitis,
  • abdominal pathology,
  • severe urinary tract infections,
  • lesions of the skin, joints, bones.

They are also prescribed in the postoperative period, after delivery by cesarean section for the prevention of infectious complications. The use of these antibiotics is not contraindicated during breastfeeding.

Adverse reactions can be in the form of allergies, dyspeptic disorders, leukopenia, anemia. When using high doses of ceftriaxone, cholestasis can develop, therefore, in pregnant women with liver pathology or elevated liver enzymes without a clinical picture of liver damage, it is used with caution.

What antibiotics from this group are allowed during pregnancy? These are Erythromycin, Azithromycin, Dzhozamitsin (trade analog Vilprafen).

Allowed antibiotics for macrolide pregnancy

The spectrum of activity is quite wide:

  • respiratory tract infections
  • dental infections,
  • skin diseases
  • infectious diseases of the genitourinary system,
  • combination therapy of Helicobacter pylori infection in the treatment of gastric ulcer.

Pregnant women are most often prescribed josamycin for the treatment of chlamydial infection, mycoplasma, gonorrhea and syphilis. In the case of chlamydia, treatment is usually prescribed in the second trimester. Drugs slightly penetrate into breast milk. But for therapy during lactation, it is recommended to use Erythromycin, as proven safe for infants.

Side effects are rare. It may be allergic reactions, abdominal discomfort, nausea, very rarely - liver dysfunction.

Drugs, contraindicated in the period of gestation

How antibiotics affect pregnancy and the fetus depends on their structure and mechanism of action.

Tetracyclines are able to penetrate the placenta, dangerous in any period of gestation. They disrupt mineral metabolism, affect the formation of bone tissue and the laying of teeth, cause aplastic anemia. During breastfeeding, the drug is also prohibited.

Fluoroquinolones Ofloxacin, Norfloxacin, Levofloxacin, which are effective against urinary tract infections, are prohibited in pregnant women. They can affect the bookmark and growth of cartilage tissue.

Aminoglycosides penetrate the placenta. With an increase in the duration of pregnancy, the ability of the placental barrier to pass an antibiotic to the fetus increases. The effect on the child is manifested in the form of damage to the auditory nerve and the development of congenital deafness. But in difficult situations when it is impossible to use another drug, Gentamicin and other members of the group use short courses.

Sometimes the effect of an antibiotic depends on the period of gestation. For example, Metronidazole (Trihopol) is contraindicated in the first trimester as potentially dangerous, but is allowed in the 2nd and 3rd trimesters of pregnancy. This drug is effective in local use for the treatment of genital infections, is the drug of choice for bacterial vaginosis.

Similarly, Furadonin, which is used in the treatment of cystitis, is prohibited for initial use. But with a normal pregnancy, they can be treated from 2 trimester.

Levomycetin is dangerous in any period of gestation. It penetrates the placenta and affects the bone marrow. It is an organ of blood formation and immunity; therefore, children are more likely to have birth with anemia, the development of neutropenia, leukocytopenia, and a decrease in platelets.

Clindamycin and Lincomycin belong to the group of macrolides, but their use is not recommended for pregnant women. They are able to penetrate the placenta and accumulate in the liver of the fetus. The concentration in the body several times higher than in the blood. The negative impact has not been fully studied, but there is a high risk of damage to the kidneys and liver of the newborn.

In order not to be mistaken with the choice of a drug for the treatment of infectious diseases, one should not self-medicate during pregnancy. Only a doctor can properly assess the condition, determine the causative agent of the disease and choose an antibacterial agent that is effective and safe in a particular situation.

Forms of release and name

The antibiotic Cefazolin is available only in the form of a dry powder intended for preparation of a solution for intramuscular or intravenous administration. The powder is packed in glass vials and hermetically sealed.

In Latin, the name of the drug is written as follows - cefazolin, which is the international name of the antibiotic. Commercial names may differ from the international one, since each pharmaceutical company may produce the drug with the active ingredient cefazolin, but give it a memorable and simple name. For example, the antibiotic cefazolin is available under the following commercial names - Amzolin, Antsef, Atraltsef, Woolmizolin, Zolin, Zolfin, Intrazolin, Ifisol, Kefzol, Lysolin, Natsef, etc. However, there are antibiotics whose name coincides with the international name of the substance, for example, Cefazolin-AKOS, Cefazolin-Sandoz, etc. All of these drugs are the same - the antibiotic Cefazolin, which is used standardly, regardless of the name and the manufacturer. Only the quality of the product itself, produced by various pharmaceutical plants, may differ.

Therapeutic effects and action spectrum of cefazolin

Cefazolin belongs to semisynthetic antibiotics from the group of beta-lactams. These antibiotics kill pathogenic bacteria, destroying their cell wall. Cefazolin is able to destroy many types of microorganisms, therefore, it refers to broad-spectrum antibiotics. Compared with other drugs from the group of cephalosporins of the first generation, it is the safest drug, because it has minimal toxicity.

The main and main therapeutic effect of Cefazolin is the destruction of the pathogenic microorganism that caused the infectious-inflammatory disease. Accordingly, the drug effectively cures infections and inflammations caused by microbes, on which Cefazolin has a destructive effect.

Today, Cefazolin is effective against the following pathogens:

  • Staphylococcus aureus (Staphylococcus aureus),
  • Epidermal Staphylococcus (Staphylococcus epidermidis),
  • Beta-hemolytic streptococci from group A,
  • Pus Streptococcus (Streptococcus pyogenes),
  • Diplococcus pneumonia (Diplococcus pneumoniae),
  • Hemolytic Streptococcus (Streptococcus hemolyticus),
  • Viridal streptococcus (Streptococcus viridans),
  • E. coli (Escherichia coli),
  • Klebsiella (Klebsiella spp.),
  • Proteus (Proteus mirabilis),
  • Enterobacter aerogenes,
  • Hemophilic bacillus (Haemophilus influenzae),
  • Salmonella (Salmonella spp.),
  • Shigella (Shigella disenteriae, etc.),
  • Neisseria (Neisseria gonorrhoeae and Neisseria meningitidis),
  • Corynebacterium (Corynebacterium diphtheriae),
  • The causative agent of anthrax (Bacillus anthracis),
  • Clostridiums (Clostridium pertringens),
  • Spirochaetes (Spirochaetoceae),
  • Treponema (Treponema spp.),
  • Leptospira (Leptospira spp.).

This means that Cefazolin is able to cure an infection of any organ caused by the above pathogenic microorganisms. Unfortunately, due to the frequent and unreasonable use of antibiotics, their spectrum of action is steadily decreasing, since persistent types of microorganisms appear. Therefore, after 5 years, this list of bacteria that are harmful to Cefazolin can change significantly.

The antibiotic does not act on the Pseudomonas aeruginosa, Mycobacterium tuberculosis, viruses, fungi and protozoa microorganisms (trichomonads, chlamydia, etc.).

Injections Cefazolin - instructions for use

Injections are placed in parts of the body where the muscular layer is well developed, for example, in the thigh, shoulder, buttock, etc. Intravenous Cefazolin may be injected in the form of injections or drip.

The powder should be diluted in the required human dosage. For example, if you want to enter 0, 5 g, then take a bottle with the appropriate dosage of Cefazolin powder. You can not take a bottle with a dosage of 1 g and divide it in half to get a dose of 500 mg. But to get a dose of 1 g, you can take two vials of 500 mg or four 250 mg each.

Intravenous injections Cefazolin at a dosage of less than 1 g is administered as a slow injection. The solution is injected into a vein within 3 to 5 minutes. If cefazolin is administered intravenously at a dosage of more than 1 g, then an IV should be used. The antibiotic solution in this case is injected for at least 30 minutes.

Antibiotic solutions must be prepared immediately before use. A quality solution should be transparent and free from any impurities, suspended particles, sediment or turbidity. A slight yellowish tint of the finished solution is allowed, which is the norm and does not indicate damage to the drug. If the resulting solution is not transparent, it can not be used. Also, do not use the solution prepared in advance. In exceptional cases, it is allowed to store the finished solution in the refrigerator for no longer than 2 days.

The dosage of cefazolin is determined by the severity of the pathology. Adults who do not suffer from renal insufficiency should receive an antibiotic in the following dosages:
1. Mild infections caused by cocci (staphylococci, streptococci) require the use of Cefazolin 500 mg - 1 g every 12 hours. You can enter 500 mg every 8 hours. The maximum daily dose is 1.5 - 2 g.
2. Acute uncomplicated urinary tract infections (urethritis, cystitis, etc.) - Cefazolin is administered at 1 g every 12 hours. The daily dose of the antibiotic is 2 g.
3. Пневмония, вызванная пневмококками, требует введения Цефазолина по 500 мг через каждые 12 часов. Суточная дозировка антибиотика составляет 1 г.
4. Severe or moderate infections require the use of Cefazolin, 500 mg - 1 g every 6 - 8 hours. The daily dose is 3 to 4 g.
5. Life-threatening infections are treated with 1 to 1.5 g of Cefazolin every 6 hours. At the same time a person receives 4 - 6 g of antibiotic per day.

It is possible to increase the dosage of Cefazolin to 12 g per day in case of a serious condition of a person, when there is a question of life and death. Elderly people who do not have impaired renal function receive Cefazolin in the usual adult dosage.

People suffering from renal failure receive Cefazolin in smaller doses. The specific dosage and interval of administration is determined by the value of the creatinine filtration coefficient (CK) according to the Reberg test. The daily, single dose and the interval of administration of Cefazolin for people with renal insufficiency are shown in the table:

If the human kidney function is unstable, it is necessary to constantly monitor creatinine clearance with the help of the Reberg test. In this case, the dose of Cefazolin is determined every day, depending on laboratory parameters.

Cefazolin injections are prescribed in a course of 7 to 14 days. The use of an antibiotic for less than 5 days is not allowed, because the pathogen can not be completely destroyed, and then resistant types will develop, which are very difficult to treat. Also, it is not recommended to use Cefazolin for longer than 14 days, as in this case, stable subspecies of microorganisms can also be formed.

Cefazolin is used not only for therapeutic purposes, but also to prevent the addition of infection during various surgical procedures. The prophylactic dosage of the drug is determined by the volume of surgery, and its duration. If the operation lasts less than 2 hours and its volume is small, then 1 g of Cefazolin is administered intramuscularly to prevent infection, 30 to 60 minutes before it starts. If the operation lasts more than 2 hours, then the scheme of Cefazolin administration is as follows: 1 g intramuscularly 30 minutes before the start, then 0.5-1 g intravenously every 2 hours during the surgical procedure.

After surgery, to prevent infection, 0.5-1 g of Cefazolin is administered every 6-8 hours during the day. If the operation was extensive, difficult and long, you can extend the course of prophylactic antibiotic use to 3 - 5 days. At the same time, it is necessary to introduce Cefazolin strictly every 6 to 8 hours in order to constantly maintain the necessary concentration of antibiotic in human blood.

If a person is allergic to penicillin antibiotics or carbapenems, it is necessary to use Cefazolin cautiously. With the development of signs of an allergic reaction, you should immediately stop using the antibiotic, or stop the introduction.

It is not recommended to use antibiotics-aminoglycosides simultaneously with Cefazolin (for example, Kanamycin, Streptomycin, Gentamicin, etc.), since in this case the risk of damage to the kidneys is significantly increased.

How to breed antibiotic Cefazolin - a recipe

For intramuscular injection, Cefazolin powder can be diluted in sterile water, lidocaine or novocaine. Since the injection of an antibiotic is very painful, it is preferable to dilute the powder in Lidocaine or Novocaine, which are painkillers.

To prepare the solution for intramuscular injection, 2 - 3 ml of sterile water, 0.5% lidocaine or 2% novocaine are injected into the powder vial. After that, the vial is shaken vigorously, until the powder is completely dissolved and a clear liquid is formed.

For intravenous injection, Cefazolin powder is dissolved in sterile water. At the same time at least 10 ml of water is necessary to ensure the administration of the drug within 3 to 5 minutes. It is allowed to dilute the antibiotic in at least 4 ml of water, based on 1 g of powder.

The solution for intravenous infusion (dropper) is prepared using 100-150 ml of the primary solvent. The following drugs are used as a solvent:

  • sterile saline
  • 5% or 10% glucose solution,
  • a solution of glucose in saline,
  • glucose solution in ringer's solution,
  • 5% or 10% solution of fructose on water for injection,
  • ringer's solution
  • 5% sodium bicarbonate solution.

Most commonly, intramuscular injections of Cefazolin are used in domestic conditions. Therefore, we consider in detail how to properly dilute the powder in solutions of anesthetics Lidocaine and Novocain.

Cefazolin with Novocain and Cefazolin with Lidocaine - how to breed?

For dilution of Cefazolin powder, 2% Novocain or 0.5% Lidocaine will be required, which are sold in pharmacies in sealed ampoules. Also need sterile syringes. The method of preparation of the solution of Cefazolin on Novocain or Lidocaine for intramuscular administration:
1. Carefully file and break off the tip of the ampoule with a 2% solution of Novocain or 0.5% Lidocaine.
2. Open a sterile syringe, put the needle on and lower it into the ampoule with Novocain or Lidocaine.
3. Dial the required amount of Novocain or Lidocaine into a syringe (2 or 4 ml).
4. Remove the syringe from the ampoule with Novocain or Lidocaine.
5. Remove the metal cap from the vial of Cefazolin powder.
6. To pierce a rubber cap of a bottle with Cefazolin with a needle of a syringe.
7. Gently squeeze the entire contents of the syringe into the vial of powder.
8. Without taking out the syringe, shake the bottle so that the powder is completely dissolved.
9. Type the ready solution in the syringe.
10. Remove the syringe from the rubber stopper and turn it upside down with a needle.
11. Tap with your finger on the surface of the syringe in the direction from the piston to the needle so that air bubbles gather at the base.
12. Press on the plunger of the syringe to release air.
13. Make an intramuscular injection.

The amount of Lidocaine or Novocain is determined by the dosage of Cefazolin. To dilute 500 mg of Cefazolin, you will need 2 ml of Novocain or Lidocaine. And for dilution of 1 g of Cefazolin, 4 ml of Novocain or Lidocaine is needed.

Cefazolin injections - instructions for use for children

Cefazolin in infants can be used only if there is an urgent need and a threat to the life of the child. In this case, the antibiotic is used only under the supervision of a physician.

The dosage of cefazolin in children is determined by the severity of the pathology and the body weight of the child. It is by weight that the daily dose of the antibiotic is calculated, which is divided into 2-4 administrations. If the child suffers from renal failure, then the glomerular filtration rate (CC), determined according to the Reberg test, also affects the dosage.

Cefazolin dosages for non-renal children are as follows:

  • In light and moderate infections, the daily dosage is calculated at the rate of 25-50 mg of antibiotic per 1 kg of the child's weight. The resulting amount is divided into 2 - 4 administrations per day.
  • In severe infections, the dosage is calculated on the basis of 100 mg of Cefazolin per 1 kg of the child's weight. The calculated daily dosage is divided into 3 - 4 administrations.
  • Newborns and prematurely weighing less than 2 kg receive Cefazolin in a single amount of 20 mg per 1 kg, every 12 hours. That is, the daily dose of the antibiotic is 40 mg per 1 kg of body weight.
  • Children older than 7 days, and with a mass of more than 2 kg, the daily dose of the drug is determined at the rate of 60 mg per 1 kg of weight.

In newborns and children under 1 month, the rate of excretion of Cefazolin is low, therefore, it is not recommended to exceed the recommended dosage.

If the child suffers from renal failure, the algorithm for determining the dosage of Cefazolin is the following:
1. Calculate the dose by body weight, as for a child not suffering from kidney disease.
2. Conduct a Rehberg test and evaluate creatinine clearance.
3. Calculate the dose of Cefazolin, which can be administered to the child, according to the ratios shown in the table:

Cefazolin injections for children - how to breed?

Children injections of Cefazolin should be diluted exclusively in solutions of Novocain or Lidocaine. And it is better to choose the anesthetic that has the best analgesic effect in this particular child. In most cases, lidocaine has a more pronounced analgesic effect, so it is recommended to use this particular drug to prepare a solution of Cefazolin for injections. If there is an opportunity, one injection of Cefazolin with Novocain can be given to the child, and one with Lidocaine, so that the baby himself can estimate which solution has the best analgesic effect.

Cefazolin powder for intramuscular injections for children is diluted immediately before use. A dose of an antibiotic less than 500 mg is diluted in 2 ml of Novocain or Lidocaine. A dose of more than 500 mg requires 4 ml of Lidocaine or Novocain. The sequence of actions for breeding Cefazolin is as follows:
1. Open the ampoule with Lidocaine or Novocain, lower the tip of the syringe needle into the solution.
2. Gather the required amount of solution - 2 or 4 ml of Novocain or Lidocaine.
3. Pierce the bottle cap with Cefazolin powder with a needle.
4. Pour Novocain or Lidocaine into the vial and, without removing the needle, vigorously mix the contents to obtain a solution.
5. Gently draw the entire contents of the vial into the syringe.
6. Remove the syringe from the vial and make an intramuscular injection.

Use during pregnancy

To date, Cefazolin has been tested only on pregnant rats. Moreover, the drug in large doses did not cause teratogenic effects, that is, did not lead to the formation of congenital deformities of the fetus. However, such controlled studies on pregnant women, for obvious reasons, were not conducted.

Cefazolin also penetrates into breast milk, although there it is detected in small concentrations. However, if necessary, its use during lactation should transfer the child to the artificial mixture at the time of treatment.

How to prick the antibiotic Cefazolin?

Intramuscularly should be administered Cefazolin only in those parts of the body where the person has a well developed muscular layer. This is usually the front and side of the thigh, buttocks, shoulders or abdominals. Since the injection is very painful, and a thickening is often formed at the injection site, it is recommended to change the areas of injection in turns. For example, one injection is placed in the buttock, the second - in the thigh, the third - in the shoulder, the fourth - in the abdominals. Then they begin again with the buttocks, and so alternate the places of Cefazolin administration until the very end of the course of treatment.

Intramuscular injection should be done slowly - at least 3 - 5 minutes, gradually introducing the medication. The needle should be inserted deep into the muscle, so that the medicine does not fall into the subcutaneous fatty tissue. After the introduction of Cefazolin, the injection site should not be heated, as this may lead to the development of aseptic inflammation. When performing injections of Cefazolin, the general requirements for the implementation of these medical procedures should be observed:
1. Treat the injection site with an antiseptic (70% alcohol, etc.).
2. Use only a sterile syringe with a sterile needle.
3. Release the air from the syringe with the prepared solution.
4. Position the needle vertically to the skin surface and insert it deep into the muscle.
5. Slowly press on the plunger, injecting the medication for 3-5 minutes.
6. Having entered all solution, to take out a needle, holding it for the edge, put on the syringe.
7. Treat the injection site with an antiseptic.

Many people use intramuscular injections of Cefazolin (especially children) needles for intravenous injection, seeking to reduce pain. However, this can not be done, since a thin needle for intravenous injection quite often slips out and goes into the thickness of the muscles, staying there for many years and causing inconvenience to the person. Surgeons often encounter similar phenomena when they have to get needles from syringes from the buttocks and thighs, which broke off and went into the "muscle" a few years ago. In addition, the use of a thinner needle does not reduce the pain of the introduction of Cefazolin.

How much prick Cefazolin?

The duration of Cefazolin use depends on the severity of the infection and the speed of recovery. The course of treatment lasts from 7 to 14 days. Do not use Cefazolin injections for less than 5 days or more than 15 days, since in this case there is a high risk of developing antibiotic-resistant types of microorganisms. These resistant microorganisms can again cause an infection, which will have to be treated again, only with the use of another, even stronger antibiotic. Unfortunately, there is a great risk that, to another antibiotic, the microorganism may be resistant. In this case, the prognosis for life is unfavorable, since there are very few antibiotics in the world that can cope with resistant microbes. And if they do not help, then you can only rely on the immunity of the sick.

That is why the use of antibiotics, including Cefazolin, must be treated responsibly. You can not throw injections as soon as the person becomes better, considering the treatment is over. A minimum of 5 days of Cefazolin injections should be made, overcoming pain and reluctance. This is especially true of children. After all, a child is faster and easier than an adult can “acquire” resistant types of microbes that will constantly cause infections that are difficult to treat.

Side effects

For the most part, the side effects of cefazolin concern the organs of the gastrointestinal tract, or are limited to hypersensitivity. If a person suffers hypersensitivity to any other medication, then the risk of developing it to cefazolin is also high. In addition, relatively often develops an increased sensitivity to the antibiotic in people who have a tendency to allergic reactions, asthma, hay fever, urticaria, etc.

Consider the specific symptoms of Cefazolin side effects from various organ systems.

Gastrointestinal tract. The most common side effects include loss of appetite, glossitis, heartburn, abdominal pain, nausea, vomiting, and diarrhea. Less likely to develop candidiasis or pseudomembranous colitis. According to laboratory tests, it is possible to increase the activity of alkaline phosphatase, AST and ALT (drug-induced hepatitis), as well as an increase in the concentration of bilirubin in the blood (congestive jaundice).

Allergic reactions. An antibiotic can cause the development of hypersensitivity reactions, which are manifested by drug fever, skin rash (urticaria), itching, spasm of the respiratory tract and an increase in the number of eosinophils in the blood. In rare cases, it may develop angioedema, joint pain, allergic nephritis, anaphylactic shock, or exudative erythema multiforme.

Blood system Rarely enough, Cefazolin can lead to a decrease in the number of neutrophils, platelets and leukocytes in the blood. This decrease in blood cells is reversible, their normal number is restored after discontinuation of the drug. Isolated cases of blood clotting disorders and the formation of hemolytic anemia were detected.

Urinary system. An increase in the concentration of urea and creatinine in the blood is possible according to laboratory tests. With the use of large doses of antibiotic may impair the functional activity of the kidneys. In this case, the dosage of Cefazolin is reduced, and further treatment is carried out under constant control of the concentration of urea and creatinine in the blood.

Local reactions. The main local reaction is severe pain when the antibiotic is administered. In some cases, a seal may form at the injection site. In rare cases, intravenous administration of an antibiotic can trigger the development of phlebitis.

Other organs and systems. Cefazolin can cause side effects such as dizziness, a feeling of pressure in the chest, cramps, dysbacteriosis, the addition of another infection, candidiasis (candidal stomatitis or vaginitis). With the development of candidiasis or the addition of another infection, it is necessary to resolve the issue of the further feasibility of using Cefazolin.

Contraindications

If you are allergic to any other antibiotics from the cephalosporins group, Cefazolin is strictly prohibited for use. If a person is allergic to penicillin antibiotics, then Cefazolin is administered carefully, preparing a kit for dealing with anaphylactic shock, since there is cross-allergenicity between these two groups of drugs.

Also, the antibiotic is contraindicated for use during pregnancy and breastfeeding. Cefazolin is not administered to infants up to 1 month since there is no scientifically confirmed information about its safety for newborns.

Cefazolin is a powerful and effective antibiotic, so the reviews about it are mostly positive. Often this drug is used to treat angina, when amoxicillin was ineffective. Especially often positive reviews about Cefazolin are left by parents who have managed to cure children of any serious infection after a long period of use of other antibiotics that have proven ineffective. Also, adults who used the drug for the treatment of acute urinary tract infections respond positively to the drug.

The negative quality of Cefazolin, according to most people, is pain injections. Однако на фоне высокой эффективности антибиотика люди воспринимают этот фактор в качестве недостатка, который, однако, вполне можно пережить и перетерпеть.

Отрицательные отзывы о Цефазолине встречаются крайне редко. Leave them to people who do not help the drug to cure the disease or caused a strong allergic reaction in the form of itching. Unfortunately, there are types of microorganisms that are resistant to Cefazolin, and allergy is one of the side effects of the drug, so it does not suit all people.

Can I take antibiotics during pregnancy: what is allowed

Antibiotics are biological substances that are synthesized by microorganisms and kill bacteria and other microbes. Without their help, it is difficult to cope with many diseases, but their reception is fraught with violations of certain functions of the body. Particularly acute is the question of whether it is possible to take antibiotics during pregnancy, since everyone is talking about the harmfulness of such therapy for the child and the expectant mother.

In fact, we need the golden mean: a complete ban on antibiotics during this period is impossible, since in some cases they prove to be vital. However, thoughtful and reasonable use of these drugs will help to avoid negative consequences.

Question and taking antibiotics during pregnancy, only the doctor decides. It is impossible to follow the recommendations of friends to self-medicate. The indications for taking such drugs are very limited. Doctors prescribe them only in the most extreme cases, when no other treatment can not help. These include:

In order to avoid serious complications in these cases, the use of antibiotics is justified: the benefit to the mother is more obvious than the risk to the fetus. Unfortunately, not all women understand that antibiotics do not neutralize all microorganisms, and they begin to self-cure such diseases as they are useless:

  • ORVI,
  • flu,
  • high temperature
  • cough,
  • bowel disorders,
  • fungal lesions (skin, mucous membranes).

Especially fraught with uncontrolled, self-administered antibiotics without a doctor's prescription in early pregnancy, when a small body is just beginning to form. The destructive effect of powerful drugs can make its own adjustments to the development of the fetus, disrupting it and adversely affecting its health.

The main consequences of taking antibiotics during pregnancy affect just the baby, not the mother itself. They are able to penetrate the placenta into the body of the child. There, they have a detrimental effect on developing, growing organs, which is fraught with later various pathologies and complications:

  • toxic effect (especially in the first trimester of pregnancy) on the auditory nerve and liver of the baby,
  • circulatory disorders
  • damage to tooth enamel,
  • slowing bone growth and the formation of severe bone defects.

Scientists are still studying the harmful effects of antibiotics on the forming organism of the future child. But the fact that in the first months of pregnancy they cause maximum damage has already been proven and is not in doubt.

Antibiotics, which are used in the 2nd and 3rd trimester, when small organs are already formed, do not cause much harm, but they can still cause future deviations from the norm. To prevent this, you need to know which drugs are allowed for pregnant women and do not pose a danger to the health and development of the baby, and which are strictly prohibited.

There are prohibited and permitted antibiotics during pregnancy - dangerous and safe. There is an intermediate group between them, which is allowed only in especially dangerous situations.

  • doxycycline,
  • tetracycline,
  • fluoroquinolones (tsiprolet, ciprofloxacin, nolitsin, floksal, abaktal),
  • clarithromycin (Fromilid, Klacid, Clubbax),
  • roxithromycin
  • midecamycin,
  • aminoglycosides (tobramycin, kanamycin, streptomycin),
  • furazidin (furagin, furamag),
  • nifuroxazide (enterofuril, ersefuril),
  • chloramphenicol (synthomycin, levomycetin, olazol),
  • dioxidine
  • co-trimoxazole (Bactrim, Biseptol, Groseptol).
  • azithromycin (zitrolide, sumamed, hemomycin, zi-factor),
  • nitrofurantoin (furadonin),
  • metronidazole (trichopol, klion, metrogil, flagel),
  • gentamicin.
  • penicillin (amoxiclav, amoxicillin, ampicillin),
  • cephalosporins (cefazolin, ceftriaxone, cefalexin, cefixime, cefuroxime, cefoperazone, ceftazidime, cefotaxime, cefepime),
  • Erythromycin
  • spiramycin (rovamycin),
  • josamycin (vilprafen).

Given these lists, a pregnant woman should be wary of any antibiotic treatment. In the first trimester, up to about 5 months, without urgent need to resort to such therapy is possible only on prescription. During this period, the formation of organs and tissues of the child occurs, and under the influence of powerful drugs, irreversible disturbances in their functioning can occur. If, after all, antibiotics have been prescribed, it is impossible to independently change the scheme, schedule, and dosages that the doctor has determined. All this is of great importance for the development of the fetus at any stage of pregnancy.

During pregnancy, a woman should, as far as possible, limit drug intake. When taking medications, the future mother risks not only her health, but, first of all, the health of her baby. However, there are situations when taking medication becomes necessary. Most often there is a need for antibacterial drugs. So is antibiotics possible during pregnancy? This question requires a very careful and competent approach. Let's try to figure it out.

Antibacterial drugs are used to treat bacterial infections. It should be remembered that these drugs do not affect viruses, are not painkillers and antipyretic drugs. In addition, antibiotics are not at all harmless medicines, which have many contraindications and can cause many side effects. Therefore, you can take them only on prescription.

It is especially important to remember a woman during pregnancy. The organism of the future mother during this period is more weakened and defenseless against various infections. Besides the fact that often a woman at this time exacerbated chronic diseases, she becomes defenseless against many colds, infectious diseases. And often there are situations when it is impossible to do without drug treatment. Antibiotics during pregnancy are necessary for the treatment of acute pyelonephritis, severe sore throat, bronchitis, pneumonia, severe intestinal infections, purulent wounds, burns. In addition, antibiotics during pregnancy prescribed for severe infectious complications, such as blood infection, sepsis. Sometimes women have specific diseases that simply require antibiotics during pregnancy. In particular, it is brucellosis (an infectious disease transmitted from animals to humans), tick-borne borreliosis (an infectious disease transmitted by ticks) and other diseases.

It is clear that in the modern world it is sometimes impossible to get away from taking antibacterial agents. Many expectant mothers are interested in how antibiotics affect pregnancy?

Antibiotics during pregnancy, in addition to the therapeutic effect, have many negative side effects. First of all, they negatively affect the human liver, the normal microflora of the body, significantly reduce immunity. For the future mother, this can have very serious consequences.

When answering the question of how antibiotics affect pregnancy, experts point out the negative effect of these drugs on a woman’s fetus.

To a large extent, this depends on the duration of the pregnancy on which the woman is located.

Antibiotics in early pregnancy are especially dangerous for the health of the future man. During this period, the laying and formation of tissues and organs of the fetus. In this case, the maternal placenta is not yet ready to protect the baby from the penetration of drugs and their damaging effects. Therefore, most antibiotics in early pregnancy are contraindicated.

In the second trimester, the main tissues and organs of the fetus are already formed. At the stage of formation are the brain of the baby and his genitals. They will develop until the birth of the child. It is allowed to take some antibiotics during the second trimester pregnancy.

In the third trimester, antibiotics of a much wider spectrum are permitted.

But in any case, the prescription of antibiotics during pregnancy should be the prescription of the drug by a doctor. Only an experienced specialist can choose the right antibacterial agent, its dosage, the duration of the course of therapy.

With the development of the slightest side effects, while taking antibiotics during pregnancy, the expectant mother should immediately consult a doctor.

All antibacterial drugs can be divided into three groups:

  • antibiotics that are absolutely contraindicated during pregnancy,
  • antibiotics that can be taken pregnant with caution
  • antibiotics that can be used during pregnancy under the supervision of a physician.

The use of the following antibiotics during pregnancy is absolutely contraindicated.

1.Tetracycline, Doxycycline - have a strong toxic effect on the liver. In addition, they are able, passing through the placenta, accumulate in the dental germs and bones of the fetus, preventing their mineralization.

2. Clarithromycin (Clabax, Fromilid, Klacid) - safety in pregnant women has not been proven.

3. Fluoroquinolones (Floxal, Abatal, Nolitsin, Ciprolet, Ciprofloxacin) are absolutely forbidden for use in pregnant women. In animal studies, their damaging effects on the joints of the fetus have been proven.

4. Roksitromitsin, Midekamitsin (Rulid, Makropen) - safety of use for pregnant women is not investigated.

5. Nifuroxazide (Enterofuril, Ersefuril), Furazidin (Furagin, Furamag) - have a potentially negative effect.

6. Aminoglycosides (Streptomycin, Tobramycin, Kanamycin) - easily penetrate the placenta, leading to complications in the inner ear and the kidneys of the fetus.

7. Chloramphenicol (Olazol, Sintomitsin, Levomycetin) - prohibited antibiotics during pregnancy because of their ability to quickly penetrate the placenta. These drugs can interfere with the division of blood cells and inhibit the baby’s bone marrow.

8. Co-trimoxazole (Groseptol, Bactrim, Biseptol) - means, the use of which leads to slower growth of the fetus, increasing the risk of heart defects, congenital malformations.

9. Dioxidin - a tool that is used in surgery to disinfect wounds. Proven mutagenic and toxic effects on the fetus of animals.

Acceptable antibiotics during pregnancy, which should be used with caution.

1. Nitrofurantoin (furadonin) - is allowed only in the second trimester of pregnancy.

2.Azithromycin (Hemomitsin, Zi-factor, Zitrolid, Sumamed) - used when absolutely necessary, in particular in the treatment of chlamydial infection in pregnant women.

3. Gentamicin - it is permissible to use only according to strict vital indications (blood infection, sepsis). It is very important to correctly calculate the dosage of the drug, since if it is exceeded there is a risk of having a deaf child.

4. Metronidazole (Flagyl, Metrogil, Trichopol, Klion) - used in the second and third trimesters of pregnancy. Able to provoke the development of defects of the brain, genitals and limbs in the fetus.

What antibiotics are possible during pregnancy.

1. Erythromycin (Rovamycin, Vilprafen) - crosses the placenta in small concentrations.

2. Cephalosporins (Cefelim, Cefotaxime, Cefixime, Ceftriaxone, Cefalexin, Cefazolin - penetrate the placenta in small concentrations.

3.Penicillin (Ampicillin, Amoxiclav, Amoxicillin) - usually does not affect the fetus.

Any drugs that a woman takes during pregnancy can adversely affect the health of her unborn child, and antibiotics are no exception. There is a group of antibiotics that the future mother is strictly contraindicated, because they can lead to abnormal development of the fetus. However, statistics show that every second woman is prescribed antibiotics during pregnancy, because many diseases simply cannot be cured in another way. Today we will try to find out: are there safe antibiotics, what effect do they have on the child and in what cases is it appropriate to take antibiotics during pregnancy.

It often happens that a woman learns about her pregnancy after an illness and taking a course of antibiotics. Such a pregnancy is accompanied by certain risks, which are associated not so much with the use of drugs, but with the infection that the expectant mother suffered. Of course, in this situation, it is impossible to do without expert advice.

The issue of pregnancy planning after taking antibiotics should be postponed, because the body after any disease needs time to recover. It is better to wait a little with conception in order to fully recover by this moment. If the pregnancy occurred during antibiotic therapy, do not worry. Medicines taken before the delay of menstruation will not affect the condition of the fetus, but in order to avoid the recurrence of infection, it is worthwhile to seriously strengthen the immune system.

In the early stages of pregnancy, antibiotics should be taken with extreme caution and only as directed by a physician. The specialist assesses the possible risks and benefits of the use of drugs, and then makes a final conclusion about the need for such treatment. Antibiotics of the penicillin group are relatively safe in the first trimester, but not all bacteria are sensitive to these drugs. For pneumonia and other dangerous diseases, antibacterial preparations of a number of cephalosporins can be used. For the treatment of diseases of ENT organs, antibiotics are prescribed topically in the first weeks of pregnancy.

The most common reasons for which pregnant women have to take antibiotics can be identified. Among them:

  • Gestational pyelonephritis,
  • Angina, bronchitis, pneumonia,
  • Severe intestinal infections,
  • Extensive injuries, burns, purulent wounds,
  • Severe infectious complications (blood poisoning, sepsis),
  • Specific diseases, the causative agents of which are rare bacteria (brucellosis, tick-borne borreliosis).

In each of these cases, the use of antibiotics during pregnancy is justified and necessary to prevent even more serious complications. In other words, the benefits to women are much higher than the risks to the fetus. But we should not forget that there is a category of diseases in which the use of antibiotics will not benefit. In particular, expectant mothers should not use these drugs for the treatment of acute respiratory infections, acute respiratory viral infections, influenza, intestinal disorders, to reduce the temperature or as an anesthetic.

All drugs in this list can be used in the period of carrying a child. But it is necessary to take into account that in any case antibiotics are potent drugs, it is forbidden to take them without a prescription. So, antibiotics allowed during pregnancy include:

  • Penicillin and its analogues (ampicillin, amoxicillin, amoxiclav) - are able to pass through the placenta, however, as a rule, they do not adversely affect the fetus. During pregnancy, rather quickly excreted by the kidneys,
  • Cephalosporins (cefazolin, ceftriaxone, cefalexin, cefixime, cefuroxime, cefotaxime, cefoperazone, cefepime, ceftazidime) are used during gestation period without restrictions. Through the placenta penetrate in low concentrations. No negative effect on the fetus has been identified.
  • Erythrocymine, josamycin and spiramycin - these antibiotics during pregnancy, as well as cephalosporins, are allowed for use. Pass through the placental barrier in small quantities, but developmental disorders and congenital abnormalities of the fetus do not cause.

Answering the question about what antibiotics are possible during pregnancy, it is necessary to select drugs that are acceptable, but require constant supervision by a specialist:

  • Azithromycin (zitrolid, zi-factor, sumamed, hemomycin) - is used only when absolutely necessary, for example, for the treatment of chlamydial infection in pregnant women. No adverse effects on the fetus
  • Nitrofurantoin (furadonin) - can be administered only in the second trimester, is prohibited in the first and third,
  • Metrodinazole (Trichopol, Klion, Flagil, Metrogil) - can not be used in the first trimester due to the risk of developing defects of the brain, limbs and genitalia in the fetus. In later periods, appointed in the absence of a safer alternative,
  • Gentamicin - this antibiotic during pregnancy is used only for health reasons in strictly calculated dosages. Excess doses of the drug is accompanied by a high risk of having a deaf child.

Above, we have listed drugs that can be taken during pregnancy, without endangering the life and health of the future baby. However, sometimes there are situations when, in the early stages of the future mother, antibiotics are prescribed, which are prohibited during pregnancy. This happens as a result of the fact that neither the woman herself nor the therapist is aware of the conception that has come. Как правило, лекарства, принимаемые на первой неделе беременности, не отражаются на здоровье будущего ребенка, но если имплантация плодного яйца уже произошла, последствия могут быть непредсказуемыми.

The degree of influence of antibiotics on pregnancy primarily depends on the drug, its dosage and gestation period. It is also important to understand that not all medicines have been studied to the end, so the possibility of taking them during pregnancy is still questionable.

Any antibiotic has a number of side effects. Besides the fact that most of them are toxic chemicals affecting the liver, many antibiotics can destroy the cells of the kidneys, inner ear and other organs. As a result of the use of these drugs, the body is deprived of protection by bacteria that live on the skin or in the intestines, because antibiotics act not only on harmful, but also on beneficial microorganisms, destroying both.

In general, taking any drugs, especially antibiotics during pregnancy, is highly undesirable. The only way to avoid this is to prepare your body and strengthen its defenses at the planning stage of the child, in order to be able to withstand various infections.

Text: Inga Stativka

From the first days of pregnancy under the influence of progesterone begins a natural decrease in immunity. It is necessary that the mother's body did not perceive the embryo as an alien object, which consists of half of the alien genetic material. Immunosuppression leads to an exacerbation of chronic infectious diseases or the development of new ones. These conditions are dangerous for the developing fetus. Until the formation of the placenta, the baby is not protected from infection, but in the later periods the bacteria can lead to complications of gestation. Therefore, treatment is necessary, but only with antibiotics permitted during pregnancy.

The doctor prescribes treatment based on the clinical guidelines of the Ministry of Health. Sometimes antibiotics are the main drug in the protocol, but there are conditions in which their prophylactic administration is necessary.

Antibacterial therapy during pregnancy is carried out in the following situations:

  • lesion of the genital organs: bacterial vaginosis, mycoplasmosis, trichomoniasis, ureaplasmosis, chlamydia, gonorrhea, syphilis,
  • pathologies of the hepatobiliary system: acute fatty degeneration, HELLP syndrome, cholecystitis,
  • respiratory diseases: pneumonia, bronchitis, antritis,
  • pathologies of the urinary tract: cystitis, pyelonephritis, single kidney,
  • infectious lesions of the digestive tract,
  • in case of miscarriage due to infection,
  • severe injuries, purulent wounds.

Also, antibiotics are prescribed after surgical interventions during pregnancy, after delivery by cesarean section and infectious complications of the postpartum period. Their choice is based on safety for the woman and the newborn child who is on breastfeeding.

All drugs undergo a lot of research, the purpose of which is not only to establish their effectiveness, but also to reveal how dangerous they are for pregnant women and the developing child. After laboratory and clinical trials, they are assigned a specific hazard category. So share drugs:

  • Group A - passed all the necessary tests. According to their results, no danger to the fetus was revealed.
  • Groups B - includes two types of drugs. The first of them was tested on animals, as a result of which no negative effect on intrauterine development was detected. The second was tested on animals and pregnant women. In humans, no effect on the fetus was found, and in pregnant females, slight undesirable effects were detected.
  • Groups C were tested on animals, negative effects on the progeny being formed were revealed - toxic, teratogenic. Therefore, clinical trials in pregnant women were not conducted.
  • Group D - after the experiments and clinical trials, a negative effect on the fetus was recorded.
  • Groups X - have a very dangerous effect.

The first two groups of drugs can be used in the treatment of pregnant women, regardless of the period of gestation. The remaining three are prohibited for the treatment of pregnant women. The consequences of their use can lead to serious complications and pathologies on the part of the fetus.

Antibacterial drugs can harm the fetus, if they are prescribed from the list of prohibited use. But much depends on the period in which the therapy was carried out.

A woman does not always plan a pregnancy and knows about its occurrence. It may be in such a situation that the egg is already fertilized, but the time of menstruation has not yet come. Bacterial infection is treated with antibacterial agents. If you drink antibiotics before the delay, their choice does not have the same value as in the first days of pregnancy, which has already been confirmed. If you undergo a course of treatment, then the principle of "all or nothing." This means that the drug will either lead to serious developmental pathologies and miscarriage, or not affect the embryo.

Taking antibiotics in the first trimester of pregnancy is associated with serious complications. During this period, there is a laying of all organs, the formation of limbs, the neural tube. Any negative effects during the period of active cell division lead to the formation of congenital malformations:

  • absence of organ - aplasia,
  • underdeveloped organ or limb - hypoplasia,
  • change in normal shape or location,
  • the formation of additional holes, fistula.

Severe effects of antibiotics in certain groups during this period are due to an unformed placenta. After attachment to the wall of the uterus and up to 10-12 weeks of development, the fetus receives food directly from the endometrial microvessels. There is no filter system that will not let in harmful substances. Only an established placenta can protect the unborn child from the action of many toxic substances and microorganisms. Therefore, the necessary antibiotic therapy in the 2nd trimester is less dangerous.

But this does not mean that it is possible to carry out treatment with the same drugs as non-pregnant ones. The middle of gestation is the period of ripening of the fetus, its active growth and the formation of thinner structures. For example, bone tissue, nervous system, organ of vision and hearing.

On the other hand, infectious diseases that have been active in the 2nd and 3rd trimester are no less dangerous for the child. They can lead to the following complications:

  • premature birth,
  • low water and high water,
  • congenital infection
  • intrauterine growth retardation
  • antenatal death,
  • feto-placental insufficiency.

Therefore, leave untreated infection can not be. When choosing an antibiotic, the doctor is guided by the principle: the prevalence of benefit to the fetus over the risk of negative consequences.

They belong to three groups of drugs:

But despite the relative safety, treatment should be coordinated with the doctor. These medicines have other side effects that are not related to pregnancy:

  • Destroy the intestinal microflora, which leads to stool disorders - diarrhea or constipation, which are caused by intestinal dysbiosis.
  • The development of dyspeptic disorders: heartburn, stomach pain, nausea. On the background of pregnancy due to frequent digestive disorders in the stomach, its displacement by the growing uterus, these symptoms bother many women. And after a course of antibiotic therapy may increase.
  • Vaginal candidiasis is a frequent companion of pregnant women, treatment with antibacterial agents will disrupt the vaginal microflora and lead to an aggravation of the fungal infection.
  • Allergic reactions may occur, even if previously the treatment with the selected drug was not accompanied by such a side effect.

Safe antibiotics have certain indications and a spectrum of activity. Also in each group there are several representatives who are allowed in pregnant women. By the level of danger, they are classified as group B.

In the treatment of pregnant women use synthetic and semi-synthetic drugs: Amoxicillin, Ampicillin, Oxacillin.

Penicillin Group Antibiotics

Penicillins have a bactericidal effect, they lead to the death of microbes by blocking the synthesis of certain substances that are part of the bacterial cell wall. Penicillins are active against the following groups of microorganisms:

  • streptococci
  • staphylococcus,
  • enterococci,
  • listeria
  • neyserii
  • Clostridiums
  • corynebacterium.

But some microorganisms have learned to defend themselves from the effects of antibiotics. They produce a special enzyme that breaks down the active ingredient. Related to this is the development of drug resistance.

Oxacillin is an antibiotic to which resistance does not naturally develop. He is able to fight infection associated with the action of staphylococcus. But against other pathogens, it does not show pronounced activity. Therefore, its use is limited.

To prevent microorganisms from becoming resistant to drugs, protected penicillins have been developed. These drugs contain additional substances that do not allow microorganisms to destroy them. These drugs include Amoxicillin / Clavulanate (Amoxiclav), Amoxicillin / Sulbactam (Sultasin).

These drugs are allowed in the first trimester of pregnancy and in the later periods. Given the spectrum of activity, they are used to treat the following diseases:

  • respiratory tract infections: sinusitis, tonsillitis, bronchitis, pneumonia,
  • diseases of the urinary system: cystitis, pyelonephritis,
  • meningitis,
  • endocarditis,
  • salmonella,
  • infections of the skin and soft tissues
  • when preparing for surgery as a prophylaxis.

Due to the low activity of Oxacillin, it is used much less frequently than Amoxiclav or Sultasin. Indications for treatment are pneumonia, sepsis, endocarditis, infections of the skin, joints and bones.

Side effects from penicillin therapy can be the following:

  • dyspeptic disorders: nausea, abdominal pain, vomiting,
  • allergic reactions, and if an allergy developed to one of the representatives of this group, a similar reaction is possible to other representatives of penicillins,
  • decrease in hemoglobin,
  • electrolyte imbalance,
  • headache.

Unwanted effects often develop with prolonged use or use in large doses.

To combine penicillins with other medications should be carefully only after consulting a doctor. For example, with bronchitis, Fluimucil is often prescribed as an expectorant. Its active ingredient is acetylcysteine. With simultaneous use with ampicillin, their chemical interaction occurs, which leads to a decrease in the activity of two drugs.

This is the most extensive group of broad-spectrum antibiotics. According to the mechanism of action and activity against certain microorganisms, they are isolated in 4 generations. The smallest range of use of the first, the widest - the last.

Cephalosporins are structurally similar to penicillins, so there may be cases of cross-allergy in the presence of intolerance to an antibiotic from the same group.

Antibiotics group cephalosporins 3 generations

The first three generations of cephalosporins are used in the form of injections and medicines for oral administration. The latest generation is only in the form of a solution for injection. So:

  • Cefazolin belongs to the 1st generation. It is used only as an injection. Cefazolin's antibacterial activity is low. Infectious diseases caused by streptococci, some strains of staphylococcus, Escherichia coli can be treated. Can not be used to suppress pneumococci, enterobacter, slightly affect Shigella, Salmonella.
  • Generation 2 is represented by Cefuroxime and Cefaclor. The first is available in the form of a solution for injections and in the form of tablets. Whether it is possible to drink antibiotics from this group in the early stages of pregnancy, the doctor must decide. Their spectrum of antibacterial activity is not wide, so they will not help with every infectious disease.
  • Cefotaxime and Ceftriaxone belong to the 3rd generation, which are identical in their activity against staphylococci, streptococci, pneumococci, meningococci, gonococci and many others.
  • Cefepime, which is very similar in its characteristics to Ceftriaxone and Cefotaxime, belongs to the 4th generation.

Pregnant women most often use the 3rd generation of cephalosporins. They are used in the following pathologies:

  • severe infections of the upper and lower respiratory tract,
  • infectious lesions of the pelvic organs,
  • sepsis,
  • meningitis,
  • abdominal pathology,
  • severe urinary tract infections,
  • lesions of the skin, joints, bones.

They are also prescribed in the postoperative period, after delivery by cesarean section for the prevention of infectious complications. The use of these antibiotics is not contraindicated during breastfeeding.

Adverse reactions can be in the form of allergies, dyspeptic disorders, leukopenia, anemia. When using high doses of ceftriaxone, cholestasis can develop, therefore, in pregnant women with liver pathology or elevated liver enzymes without a clinical picture of liver damage, it is used with caution.

What antibiotics from this group are allowed during pregnancy? These are Erythromycin, Azithromycin, Dzhozamitsin (trade analog Vilprafen).

Allowed antibiotics for macrolide pregnancy

The spectrum of activity is quite wide:

  • respiratory tract infections
  • dental infections,
  • skin diseases
  • infectious diseases of the genitourinary system,
  • combination therapy of Helicobacter pylori infection in the treatment of gastric ulcer.

Pregnant women are most often prescribed josamycin for the treatment of chlamydial infection, mycoplasma, gonorrhea and syphilis. In the case of chlamydia, treatment is usually prescribed in the second trimester. Drugs slightly penetrate into breast milk. But for therapy during lactation, it is recommended to use Erythromycin, as proven safe for infants.

Side effects are rare. It may be allergic reactions, abdominal discomfort, nausea, very rarely - liver dysfunction.

How antibiotics affect pregnancy and the fetus depends on their structure and mechanism of action.

Tetracyclines are able to penetrate the placenta, dangerous in any period of gestation. They disrupt mineral metabolism, affect the formation of bone tissue and the laying of teeth, cause aplastic anemia. During breastfeeding, the drug is also prohibited.

Fluoroquinolones Ofloxacin, Norfloxacin, Levofloxacin, which are effective against urinary tract infections, are prohibited in pregnant women. They can affect the bookmark and growth of cartilage tissue.

Aminoglycosides penetrate the placenta. With an increase in the duration of pregnancy, the ability of the placental barrier to pass an antibiotic to the fetus increases. The effect on the child is manifested in the form of damage to the auditory nerve and the development of congenital deafness. But in difficult situations when it is impossible to use another drug, Gentamicin and other members of the group use short courses.

Sometimes the effect of an antibiotic depends on the period of gestation. For example, Metronidazole (Trihopol) is contraindicated in the first trimester as potentially dangerous, but is allowed in the 2nd and 3rd trimesters of pregnancy. This drug is effective in local use for the treatment of genital infections, is the drug of choice for bacterial vaginosis.

Similarly, Furadonin, which is used in the treatment of cystitis, is prohibited for initial use. But with a normal pregnancy, they can be treated from 2 trimester.

Levomycetin is dangerous in any period of gestation. It penetrates the placenta and affects the bone marrow. It is an organ of blood formation and immunity; therefore, children are more likely to have birth with anemia, the development of neutropenia, leukocytopenia, and a decrease in platelets.

Clindamycin and Lincomycin belong to the group of macrolides, but their use is not recommended for pregnant women. They are able to penetrate the placenta and accumulate in the liver of the fetus. The concentration in the body several times higher than in the blood. The negative impact has not been fully studied, but there is a high risk of damage to the kidneys and liver of the newborn.

In order not to be mistaken with the choice of a drug for the treatment of infectious diseases, one should not self-medicate during pregnancy. Only a doctor can properly assess the condition, determine the causative agent of the disease and choose an antibacterial agent that is effective and safe in a particular situation.

The beginning of pregnancy is a time when a woman has to be careful about everything that can affect her condition. She tries to eat right, walk a lot, get more positive emotions. But this is not always able to save from the disease, and therefore, medication. Can antibiotics be used in the treatment of pregnancy in the early stages and which ones?

It is impossible to know about pregnancy until the first obvious signs appear. And if it was not planned, most likely, the symptoms will appear after a delay. And before that, a woman leads a habitual way of life in which antibiotic treatment can also be a place. And having discovered their condition, many people are frightened that they have irreparably harmed their unborn child by taking them.

Experts say that there are no grounds for fear.Of course, an embryo at this stage of development is a very fragile substance. Not yet formed tissue that could protect it. And if the fertilized egg was subjected to irreversible negative effects, the body will most likely reject it. This is the worst that may threaten pregnancy. In the normal development of the embryo, this will not happen. But the situation needs to be controlled along with the doctor. The specialist, in order to ensure proper tracking, may prescribe different types of examinations that would not otherwise be carried out so often. But to abandon them is not worth it, so as not to miss a possible pathology of fetal development.

Taking antibiotics in early pregnancy is acceptable if there are serious indications to it, including:

  • Gestational pyelonephritis. The disease often haunts women in this state, increases the burden on the excretory system of the expectant mother. And it threatens her life, so it must be eliminated. The treatment is carried out in the hospital.
  • Diseases of the respiratory system. Do not take an antibiotic at the slightest manifestation. There are remedies that can help without affecting the fetus, and they are not antibacterial. But whichever respiratory organ is affected, any of the infections show a cough. Without the necessary treatment, this symptom will develop to such a level that spasms of uterine smooth muscle may occur. And this is a direct threat of miscarriage. With such a development, the doctor may prescribe an antibiotic.
  • Intestinal infections. Another possibility of interruption and the lack of ability to absorb nutrients, vitamins and trace elements. But the diagnosis must be made by a specialist, since not any diarrhea is a sign of the infectious origin of the disease.
  • Purulent wounds, injuries occupying a large area of ​​damage.
  • Infections caused by specific pathogens. These are brucellosis, Lyme disease, etc. Nothing else but antibiotics cannot get rid of them. These diseases pose a threat to the life of the mother and are transmitted to the fetus.
  • Blood poisoning. It is also a life-threatening condition that cannot be removed by any other means.
  • Many water. An increased amount of amniotic fluid may be caused by an infection. Then no antibiotics can not do, because otherwise there is a threat of infection of the fetus.
  • Cystitis. An inflamed bladder becomes so due to an infection that can spread to the reproductive organs. This is dangerous for the fetus and pregnancy, therefore, antibiotic treatment is advisable.

In each case, its absence can lead to more serious results than the use of drugs. They should be appointed only by a specialist, he will determine the dosage and duration of therapy.

You can not use antibiotics for ordinary colds, the slightest indisposition, fever, as many used to do.

Among the many antibacterial agents there are those that can be used by pregnant women. But their appointment is the prerogative of the doctor, independent use is unacceptable. In any case, these are potent drugs that are only shown when nothing else can be replaced with them.

Permitted antibiotics during early pregnancy:

  • Related to the penicillin group. In addition to the drug itself, it is also Ampicillin, Amoxiclav, Amoxicillin. They have the ability to seep through the placenta, but the negative effects on the fetus during their use are not marked. An important advantage of this group of drugs is that they are rapidly excreted by the kidneys, without injuring their cells,
  • Included in the group of cephalosporins. Ceftriaxone, Cefixime, Cefazolin, Cefotaxime, Ceftazidime, Cefoperazone, Cefepime, Cefuroxime can be used when antibiotics are needed at an early stage of pregnancy. Their components are introduced through the placenta in modest quantities and are not capable of harming its development,
  • Erythromycin, Josamycin, Spiramycin are also allowed to receive pregnant women in the first trimester. The placental barrier is not an obstacle to the penetration of their components to the fetus, but they are not able to cause anomalies of its development,
  • Representing a group of macrolides Azithromycin, Hemomitsin, Zitrolid, Sumamed, Clarithromycin. Their negative impact on the embryo is not detected, but these drugs are prescribed only as a last resort. They can have a strong side effect on the organism of the future mother. If antibiotics from this list are used during early pregnancy, the strictest medical supervision is required.

We advise you to read the article about vitamins and checks that are prescribed in the first trimester of pregnancy. From it you will learn about the necessary tests to be taken and a list of vitamins necessary for your baby.

What antibacterial agents are prohibited in the first months of pregnancy

Given the adverse reactions and the toxicity of the components of some antibiotics, many of them are categorically not recommended for use at an early period:

  • Drugs belonging to the aminoglycoside group. These are Neomycin, Gentamicin, Amikacin. They easily penetrate to the tissues of the fetus, leaving them with toxic substances than provoke severe malformations,
  • Tetracycline preparations. These are tetracycline and doxycycline. These funds also tend to settle in the cells of the fetus, causing irreversible changes. Tetracyclines have a negative effect on the liver of the expectant mother,
  • Nitrofurans, which include furazolidone and furadonin used in urinary system diseases. In the early stages of pregnancy, these antibiotics have a negative effect mainly on the fetus, causing irreversible changes in its tissues,
  • Fluoroquinolones. Antibiotics belonging to this species, that is, Ciprofloxacin, Abactal, Floxal, are also introduced into fetal tissue, causing developmental abnormalities.

The first months of fetal development are a particularly important period. This is the time of the formation of all its organs and systems. Already in the second or third week, the rudiments of nervous, excretory, respiratory, digestive, circulatory appear. By the monthly age of the embryo, it has a spine and muscular system. The formation of the brain begins on the 5th week, and the placenta, designed to nourish and protect the fetus, is formed only from the 6th. Therefore, the effect of antibiotics may be decisive for the health of the future infant. Any of the drugs has a bunch of side effects that can bring unpredictable results for a fragile new life. In addition, antibiotics are known for their toxicity in relation not only to bacteria, but also to cells. This property of them can interfere with the proper development of the liver, kidneys, organs of hearing. Their negative impact will be on the immunity of the future baby.

For women, the reception is also not in vain. In addition to the therapeutic effect, antibiotics provoke skin reactions, digestive disorders, which can interfere with the general well-being and ability to absorb the necessary nutrients. They cause intestinal upset, increase the manifestations of toxicosis.

It is important that antibiotics can reduce the effectiveness of many other drugs that a pregnant woman has to take constantly. And it does not matter what way the drug is introduced into the body: orally, by intravenous or intramuscular injection, rectally or vaginally.

What is the harm

There are dangerous consequences of taking antibiotics in early pregnancy, which threaten both the situation itself and the embryo. It has already been said that uncontrolled use can cause its interruption. It is caused not so much by the inability of the female body to endure pregnancy, as by fetal abnormalities. Changes in its tissues due to medications make the embryo unviable. The toxicity of drugs plays a negative role in this.

How certain groups of antibiotics affect cells in the body.

Before using antibiotics at an early stage of pregnancy, than it is dangerous for a child in a specific expression, every future mom should know:

  • Aminoglycosides can lead to congenital deafness of the infant, as well as severe kidney disease,
  • Tetracyclines prevent proper mineral metabolism, so the child is likely to have to suffer with his teeth all his life. The preparations of this group negatively affect the formation of the primordia of these organs. Congenital liver disease is also the "merit" of tetracyclines,
  • Fluorquinolone antibiotics in early pregnancy will lead to disturbances in the formation of bone and cartilage tissues of the future infant,
  • Metronidazole, Metrogyl, Trichopol may further cause the formation of malignant tumors in a child, as well as defects in the development of the brain, limbs and reproductive organs,
  • Sulfanilamides provoke violations in the formation of the hematopoietic system of the fetus,
  • Reception of nitrofurans will provide abnormalities in the development of the urinary system of the embryo.

This is not the whole list of possible harm from uncontrolled reception and the wrong choice of antibiotics during early pregnancy. It has been proven that the immunity of a woman for the whole of her period is reduced, since all of its resources are aimed at carrying. One sign of this is a change in the acidity of the vagina. Taking antibiotics in early pregnancy can promote reproduction in the organ of the fungus, and therefore the appearance of thrush. Itching and burning of the mucous, unpleasantly smelling discharge will not add comfort in this state. It is more difficult to get rid of thrush during pregnancy, as many antifungal drugs are also prohibited. In addition, there is a danger of returning the infection, and therefore, infection with it during the birth of the baby.

If you drink antibiotics in early pregnancy, you should follow a few rules:

  • If you feel unwell, you should be examined by a specialist and entrust the choice of the drug to him, and not to take what once helped,
  • Inform the doctor about all existing health problems, including the previously observed allergy to drugs,
  • Observe the prescribed dosage of the drug,
  • To adhere to the terms of treatment, without canceling the drugs without authorization and not trying to “stock up on duty” for longer use,
  • Use original drugs for therapy, not generics.
  • If a side effect is noticed, tell the doctor about it,
  • Do not refuse treatment in the hospital if a specialist insists on it.

It is no secret that many women had to take antibiotics during pregnancy in the early stages. Therefore, if there is a serious testimony and prescription of a doctor, one should not “show heroism” and refuse to use them. This can cause even more damage to the baby. Acceptance of approved drugs in the optimal dosage will relieve infection, will not prevent further pregnancy and the normal development of the fetus.

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