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How to use the drug methionine?

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The substance methionine, which gave the name of the drug to restore the functions of the liver, is artificially recreated from synthetic derivatives of the amino acid - vitamin U. Since this element is not produced in the human body and can only come from outside, in the form of food or drugs, its deficiency is very often noted increased blood density of low-density lipoprotein (bad cholesterol) or a decrease in the quality of metabolism.

Release form and composition

The drug "Methionine" is available only in the form of tablets with a pink coating containing sucrose. The form of tablets is round, with no transverse risks, and mottled inclusions are possible on the surface, which are the result of incomplete dissolution of the dry substance of the sweet shell.

In the composition of the means, in addition to the active element - methionine (0.25 g), the following excipients are present:

The release of the drug from the pharmacy is free, without a doctor's prescription. There are two types of medicine packaging available: for use in hospitals - 50 tablets in a plastic can and 5 tablets in blister packs of 1.2, 5 pcs. in a cardboard box with instructions inside.

Drug action

If you believe the instructions for the use of tablets "Metionine" and reviews, there is a lack of additional data about the use of means for losing weight or facilitating the building of muscle mass. However, due to the rich range of beneficial elements in the composition of the active substance, which have a positive effect on the human body, the drug is often taken as an antioxidant and an additional source of sulfur in the process of following different diets.

It is possible to highlight the range of beneficial effects of the drug, confirmed by the reviews of the tablets "Metionin":

  • cell renewal and restoration of damaged intercellular connections,
  • improved lipid metabolism
  • stimulation of the gastrointestinal tract,
  • restoration of liver tissue
  • vascular cleansing and vascular tone enhancement,
  • smoothing allergic reactions.

The drug includes all the advantages of pure substance methionine, that is, inhibits the activity of foreign chemical compounds that are not natural to the body, eliminates the risk of fatty liver, reduces the possibility of formation of stones in the bile ducts. The available medical reviews about "Methionine" complement the list of properties of the drug with such important points as:

  • help in reproduction of creatine and adrenaline,
  • strengthening the effect on the body of vitamins B and C,
  • stimulation of enhanced protein and enzyme production,
  • increase in the content of phospholipids in the vessels while reducing bad cholesterol.

Due to the action of the drug "Methionine" (read the instructions for use, price, reviews and analogues), the restoration of the main filtering organ, the liver, is launched. Against the background of the course administration, a gradual elimination of accumulated toxins from the body occurs, which leads to a strengthening of the immune system and an increase in the stability of the nervous system.

Indications for use of the drug

According to the instructions for use and reviews, Methionine is used to treat the liver in diseases accompanied by the accumulation of fat in the filtration organ, that is, in hepatosis of any origin, including those resulting from alcoholism. Other liver diseases against which the drug is used are:

  • toxic hepatitis,
  • cirrhosis,
  • toxic poisoning
  • liver atrophy.

Often, "Methionine" is used as an auxiliary drug for mainly long-term treatment of atherosclerotic diseases and diabetes. As a prophylactic agent, it is prescribed to people who have a critical threat of arsenic poisoning, ethanol, and benzene.

Instructions for use

In the application of "Methionine", according to patients, it is better to adhere to the traditional treatment regimen, which implies a continuous course, lasting from ten days to a month. According to this therapeutic algorithm, the drug at a dosage of 500 to 1500 mg (for an adult), is drunk 30 minutes before a meal, 3-4 times a day. The duration of the course is calculated by the attending physician depending on the complexity of the existing pathology.

The proportions of the drug for the reception of children are listed below in the recommended dosages, which should not be exceeded without the special prescription of a doctor

  • children from 0 to 1 year - up to 100 mg, 3 r / day,
  • children from 1 to 2 years old - up to 200 mg, 3-4 p / day,
  • children from 3 to 4 years old - up to 250 mg, 3-4 p / day,
  • children from 5 to 6 years old - up to 300 mg, 3-4 p / day,
  • children of primary school age - up to 500 mg, 3-4 p / day.

In coordination with the attending physician, the treatment tactics may look different: if the indicated dosages are observed, the drug is taken for only 10 days, then the same pause and again a 10-day short course.

Side effects

Side effects of the drug, according to reviews of "Methionine", occur only in two cases - with individual intolerance of the active substance or significant (or repeated) exceeding the permissible dosage of the drug. In both cases, the primary symptoms will be about the same and consist in the feeling of nausea, less often - vomiting, lowering of blood pressure. In some cases, a strong excess of a single dose of the drug leads to increased heartbeat, sweating, blanching and cooling of the extremities.

Regular overdose of "Methionine", according to reviews of patients and doctors, leads to increased signs of poisoning and exacerbation of current diseases:

  • the formation of cancer cells in place of existing tumor formations,
  • vascular deterioration
  • overexcitement, transient fainting,
  • local lesions of the mucous tissues of the liver.

It should be noted that allergic manifestations associated with taking Methionine, according to reviews of victims, often take the reaction of rejection of the body when the gag reflex and even dizziness are caused by a strong smell and unpleasant taste of the drug.

Contraindications

Absolute contraindications to the reception of "Metionine" instruction and feedback from experts call:

  • chronic liver failure
  • allergic to the active substance
  • viral hepatitis,
  • irreversible hepatic encephalopathy.

Relative contraindications include pregnancy. This warning is associated with the property of the drug to provoke an acceleration of blood clotting, which may contribute to thrombosis and loss of the fetus.

Help in building muscle

Officially, the drug is not used in combination with drugs that promote muscle building, and is not intended to be taken for non-therapeutic purposes. However, contrary to the instructions for use in the reviews of "Methionine" bodybuilders often call the product necessary for keeping the body in a healthy tone during the period of exhausting workouts.

Proper distribution of fats and timely removal of their surplus from the vessels is one of the main tasks of antioxidants from the point of view of professional athletes, and with respect to Metionina, the scope of inquiries is expanded by its capabilities that can be used to improve results. So, sports nutrition is impossible without amino acids, stimulating the production of creatinine - a metabolite that occurs during the breakdown of protein elements, and without methionine, this process is quite complicated.

For the purpose of sports stimulation, pills are taken three times a day, 30 minutes before a meal, at a dosage calculated on the basis of the actual bodybuilder body weight. The amount of the drug taken in any case should not exceed 2 tablets at a time.

Drug as a means to lose weight

As a drug for weight loss, Methionine, according to reviews, is used quite often and even under the appropriate supervision of experienced nutritionists, but the old school doctors remain against the introduction of medication into practice, not related to the treatment of specific diseases. There are medical forums created by dietitians with years of experience specifically to warn young colleagues about prescribing drugs for drying the body. However, the undoubted benefits of "Metionine" for the body during low-calorie diets contribute to the fact that the drug is on the list of means for rapid and relatively safe weight loss.

According to a large number of enthusiastic comments from visitors of nutritional cabinets, with the help of the drug, 10 to 17 kilos of unnecessary weight can be eliminated in one month. At the same time, people do not feel fatigue, drowsiness and bowel problems, usually occurring against a background of food restriction.

additional information

"Methionine" is not an independent drug, and in some cases, its inclusion in the treatment regimen may even be dangerous. The high content of amino acids in the drug requires the prior delivery of a blood test before prescribing the drug, in order to eliminate the possibility of an oversaturation of the body with this substance.

During the period of taking the drug will have to give up fatty foods and increase the amount of protein consumed. For people with high body mass or high severity of the disease, who take the maximum allowable dosage of the drug, take Metionine together with B vitamins, in particular, B9, since folic acid supports the normal state of red blood cells and reduces the risk of blood clots .

For patients with pronounced diseases of the heart and blood vessels or arthritis, as well as those who are not able to deny themselves in the use of abundant fatty foods, Methionine is prescribed in small or medium dosages with appropriate medical supervision.

Analogs of prerarat for pharmaceuticals are: "Sirin", "Levolact", "Limfosan" and others.

The average price of "Methionine" in tablets in Russia ranges from 30 to 90 rubles, depending on the packaging of the drug. However, the information presented does not apply to a substance that is sold in its pure form and has the same name, as well as funds that are produced under other trade names and include methionine in the composition of the active elements.

Forms of release and composition

Available in pharmacies, this tool only in the form of tablets. The package contains 50 pcs. The active substance is the compound of the same name. Its concentration in 1 tablet is 0.25 g. Other substances that are used to obtain the desired consistency do not exhibit hepatoprotective activity as part of the preparation:

  • potato starch,
  • methylcellulose,
  • microcrystalline cellulose,
  • stearic acid,
  • hypromellose,
  • polysorbate,
  • talc,
  • titanium dioxide,
  • dye.

The tablets are coated to prevent premature release of the active ingredient. This reduces the intensity of its aggressive action on the epithelium of the stomach. As a result, the risk of side effects is reduced.

Mechanism of action of Methionine

The main properties of the drug - hepatoprotective, metabolic. Under the influence of methionine, there is an increase in liver resistance to external factors of a negative nature. Normalized detoxification ability of the body. During the treatment of liver diseases, the risk of complications decreases, the condition gradually normalizes, and the severity of negative manifestations decreases.

Pharmacodynamics

The agent in question is a hepatoprotector containing amino acids. These are substances of natural origin, which are part of the amine, carboxyl groups. The active compound is an amino acid (aliphatic, sulfur-containing). This substance is involved in the synthesis of choline, cysteine, sulfur, adrenaline.

A multistep transformation of the amino acid occurs in the body, followed by the release of a number of compounds (homocysteine, methionine sulfoxide, sulfone). Previously, this substance was obtained from natural components. Today it is possible to synthesize it artificially. The high demand for products containing such an amino acid is due to the fact that it is not produced in the body.

You can fill the deficit with food:

  • chicken eggs,
  • sesame,
  • flour,
  • nuts,
  • chicken meat,
  • tuna,
  • oats,
  • wheat germ
  • corn,
  • cabbage,
  • risk,
  • legumes.

Another advantage of the active ingredient is the ability to influence the process of lipid metabolism and normalize cholesterol levels. Under its influence the removal of fat from the liver is accelerated. This reduces the risk of developing various diseases. In addition, methionine contributes to the growth of the intensity of phospholipid production. Given these properties, an improvement in the phospholipid / cholesterol ratio is observed, which is caused by an increase in the concentration of the former and a decrease in the content of the second of the substances.

In addition, the drug in question has a positive effect on the processes occurring in the kidneys. Additionally marked antidepressant effect. Due to this effect due to the participation of amino acids in the process of adrenaline synthesis. Some of its derivatives exhibit pronounced properties: cytoprotective, anti-cicatrization, regenerating. Due to this, the restoration of damaged liver tissues and digestive tract organs is noted.

Another function of methionine is the activation of growth. Under the influence of this amino acid, an increase in the efficiency of a number of useful substances is noted: vitamin B6, B12, ascorbic and folic acids, as well as hormones and some enzymes. Due to the ability to normalize cholesterol levels, the development of complications associated with vascular diseases, including atherosclerosis.

Benefit and harm

While taking the amino acid methionine, there is a general improvement in the condition of the body. Appears cheerfulness, passes weakness in the body. The drug contributes to the nutritional value of products. As a result, a shortage of a number of substances is filled. This is due to the activation of the synthesis of beneficial compounds that enter the body with food.

As a result, normalization of the provision of tissues with vitamins and trace elements necessary for maintaining hair, skin, nails, liver, kidneys and other organs in a normal state is noted. Amino acid in the composition of various tools used in sports to increase muscle mass. This property is due to the normalization of the process of protein digestibility.

The drug is effective in diseases such as cirrhosis of the liver. With methionine therapy, there is a decrease in the intensity of aggressive effects on this organ. Thanks to this, its main functions are restored. Additionally, there is a positive effect on the body during sports, on muscle tissue in particular. However, with regular intake of anabolic steroids, medication containing an amino acid is not used. This is due to its insufficiently high efficiency as an anabolic.

Despite the vast scope and the presence of many positive properties, the amino acid has several disadvantages. More precisely, it is not the substance itself that harms the body, but those processes that are activated under its influence. Thus, acceleration of aging is noted, the body's sensitivity to insulin increases, the level of glucose in the blood increases, the risk of obesity increases, and at the same time the likelihood of signs of a heart attack, stroke.

Indications for use of Methionine

It is advisable to use an agent containing an amino acid, in some cases:

  • the development of pathological processes that are accompanied by the penetration of fat in the liver, which is possible with hepatitis, cirrhosis, hepatosis, dystrophy of this organ, as well as with alcohol poisoning,
  • diabetes,
  • atherosclerotic vascular disease,
  • lack of protein in various pathologies,
  • prevention of chemical poisoning, such as arsenic, alcohol.

How to take Methionine

The dose is selected taking into account the age, condition of the patient. Plays a role and type of the disease, as well as the degree of its development.

The tool is prescribed before meals. The recommended time is from 30 minutes to 1 hour.

In most cases, a fixed dose of 0.5 g is prescribed. The frequency of administration is no more than 4 times per day. The duration of the course of therapy is 10-30 days.

However, in some conditions, intermittent treatment may be recommended. In these cases, the course of therapy lasts 30 days: take the pills for 10 days, then maintain a gap (1.5 weeks) and resume treatment.

Patients under 18 years of age are prescribed different amounts of the drug:

  • children under 12 months are advised to take 0.1 g several times a day,
  • at the age of 2 years appoint 0.2 g
  • patients up to 4 years old increase the amount of Methionine to 0.25 g (single dose),
  • under 6 years old, it is enough to take 0.3 g each,
  • children from 7 years old may be recommended an adult dose of 0.5 g several times a day.

The frequency of taking the drug in childhood is the same as for patients over 18 years of age: 3-4 times a day.

Side effects

The positive qualities of the means include the minimum number of negative reactions.

Some patients have nausea, with increasing intensity of the influence of amino acids, vomiting occurs. Given that the active ingredient is included in the composition of various products that are basic to the human diet, adverse reactions during therapy occur infrequently.

If you are hypersensitive to any substance that contains Methionine, an allergy develops.

Overdose

If you take the drug in increased quantities, the following symptoms occur: hypotension, impaired consciousness, tachycardia. With an increase in the intensity of these manifestations, it is necessary to stop therapy until the signs of pathological conditions are eliminated. In this case, symptomatic treatment is required.

Effect on concentration

When complying with the dosage means can be used during the occupation of activities requiring increased attentiveness. However, violation of the treatment regimen (increase in the amount of the active component) leads to the occurrence of dangerous manifestations. Therefore, care should be taken when driving, and at the same time to control the dose of medication.

Analogs Methionine

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Instructions for use to methionine

Tradename : Methionine

International non-proprietary name : methionine

Chemical name : D, L-α-amino-γ-methylthiophenol acid

Dosage Form : coated tablets

Composition
Active substance: methionine 250 mg.
Excipients: potato starch, methylcellulose, microcrystalline cellulose, stearic acid, hypromellose (hydroxypropylmethylcellulose), polysorbate (tween 80), talc, titanium dioxide, dye azorubine (acid red 2C).

Description
Tablets are round, biconvex, coated pink.

Pharmacotherapeutic group : metabolic agent

PBX code : А05ВА

Pharmacological properties
It has a metabolic, hepatoprotective effect. An essential amino acid donor of mobile methyl groups is necessary for the synthesis of choline, which is deficient in violation of the synthesis of phospholipids from fats and the deposition of neutral fat in the liver.
Participates in the metabolism of sulfur-containing amino acids, in the synthesis of epinephrine, creatinine and other biologically important compounds, activates the action of hormones, vitamins (B12, ascorbic, folic acids), enzymes, proteins, peremetylation, deamination, decarboxylation, etc.
Required for detoxification of xenobiotics. When atherosclerosis reduces the concentration of cholesterol and increases the concentration of blood phospholipids.

Indications for use
Liver diseases proceeding with fatty infiltration of hepatocytes: toxic hepatitis, hepatosis (including alcoholic), cirrhosis, liver dystrophy, intoxication. Prevention of toxic liver damage with arsenic, chloroform, benzene, alcohol.
As part of combination therapy: protein deficiency of various origins, atherosclerosis, diabetes.

Contraindications
Viral hepatitis, severe liver failure, hepatic encephalopathy, hypersensitivity to the components of the drug.

Carefully - renal failure (danger of increasing hyperazotemia).

Dosage and administration
Inside Adults on 0.5 g (2 tablets) - 1.5 g (6 tablets), for children over 6 years old on 0.25 g (1 tablet) - 0.5 g (2 tablets) 3-4 times a day for 30 -60 minutes before meals. The course of treatment is 10-30 days. Also appointed by courses of 10 days with 10-day breaks.

Side effect
Allergic reactions, nausea, vomiting.

Overdose
Symptoms: decrease in arterial pressure, tachycardia, confusion. Treatment: symptomatic.

special instructions
The drug should be prescribed in a balanced ratio with other amino acids. Unbalanced use of methionine in large doses can have a damaging effect on the cells of the liver and other organs.

Release form
250 mg coated tablets. On 10 tablets in a blister strip packaging from a film of polyvinyl chloride and aluminum foil. 5 planimetric packagings together with the application instruction in a pack from a cardboard.

Storage conditions
In a dry, protected from light, out of reach of children at a temperature not higher than 25 ° C.

Shelf life
4 years. Do not use after the expiration date printed on the package.

Pharmacy sales terms : on prescription.

Pharmacological effect

This amino acid has several important properties that can be useful to both the athlete and the average person. Here are some of them:

  1. Serves as a source for the synthesis of adrenaline. Thus, if you feel that you lack this particular hormone, its synthesis can be increased by using an additive.
  2. Allows you to increase the value of vegetable protein. Since vegetable protein is only partially absorbed, the addition of essential amino acids, one of which is methionine, allows you to increase the digestibility of vegetable protein, which will certainly affect the growth of muscle mass.
  3. Adding methionine to animal feed improves the biological value of food. Similar studies were conducted on human food, which also became more valuable with the addition of an essential amino acid.
  4. One of the most important properties - the effect on liver function. It is prescribed to patients suffering from cirrhosis of the liver, as well as to people and athletes who have certain (not any) problems with this organ.
  5. High dosages help lower blood cholesterol levels. In the West, supplementation with protein nutrition is prescribed for those who suffer from high cholesterol. We have not yet taken this innovation.

There is also evidence that high dosages have a positive effect on the healing of duodenal ulcerative wounds. The additive has a similar effect in the fight against the treatment of erosive lesions of the gastric mucosa. Thus, it is effective in combating ulcers and gastritis. However, this efficiency should not be overstated either.

Use during pregnancy and lactation

Methionine's safety information for pregnant and lactating is not.

However, it is known that methionine affects the development of the fetal neural tube in the fetus (this is the rudimentary nervous system). If the body lacks this substance (after all, essential amino acids are not produced by themselves, they come only with food and specialized drugs such as Methionine), the neural tube will not close, and the embryo will have various disorders and defects of the nervous system.

Therefore, it is advisable to replenish the lack of this substance in pregnant women not with drugs, but with the help of a special diet containing meat, cottage cheese, milk, chicken eggs, etc.

Dosage and method of use

The instructions for use indicate that Metionin tablets are taken orally 30-60 minutes before meals.

Recommended single dose of the drug:

  • Adults: 2-6 tablets,
  • Children over 6 years: 1-2 tablets.
  • The frequency of taking the drug 3-4 times a day, the duration of therapy is from 10 to 30 days.

Alternative use of the drug - alternating 10 days of taking pills with a ten-day break.

special instructions

The drug should be prescribed in a balanced ratio with other amino acids. Unbalanced use of methionine in large doses can have a damaging effect on the cells of the liver and other organs.

The drug does not affect the ability to drive a car and engage in potentially hazardous activities that require increased attention and speed of mental and motor responses.

Drug interaction

Information about the interaction with other drugs is missing.

We picked up some reviews of people taking the drug Methionine:

  1. Igor Took before Ovesol to maintain the liver, there are no special reasons, so for prevention. And then I heard about methionine, supposedly it also helps the liver, and besides it costs a penny. A pack of 50 tablets worth a little more than 100 rubles. But taking them is inconvenient, three times a day an hour before meals. You do not always understand when you sit down to eat, especially at work. I saw the first time on a course like nothing, but it seems to me that it doesn’t really work, that is, it’s going to work for prevention, but if anyone already has any problems, then it’s unlikely that you will have to take something more serious.
  2. Kirill . I am a bodybuilder and take methionine every few months for 2 weeks to remove ammonia from the body that was formed after the breakdown of protein. I don’t notice much improvement in terms of health, but I don’t feel as I understand something, so I hope for a positive result and that it helps. I also had no adverse reactions

Structural analogues of the active substance:

Before using analogues consult your doctor.

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