Gynecology

Monural - instructions for use, analogues, reviews, price

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The broad-spectrum antibiotic, a derivative of phosphonic acid, has a bactericidal effect, the mechanism of which is associated with the suppression of the first stage of the synthesis of the bacterial cell wall. It is a structural analogue of phosphoenol pyruvate, enters into a competitive interaction with the enzyme N-acetyl-glucosamino-3-o-enolpyruvil transferase. As a result, specific, selective and irreversible inhibition of this enzyme occurs, which ensures the absence of cross-resistance with other classes of antibiotics and the possibility of synergism with other antibiotics (synergism with amoxicillin, cephalexin, pimemidic acid is noted in vitro).

Active in vitro against most gram-positive microorganisms: Enterococcus spp., Staphylococcus aureus, Staphylococcus saprophyticus, Staphylococcus sapp. Proteus mirabilis, Pseudomonas spp., Serratia spp. In vitro fosfomycin reduces the adhesion of a number of bacteria to the epithelium of the urinary tract.

Pharmacokinetics

After ingestion is rapidly absorbed from the gastrointestinal tract. Bioavailability with a single dose of 3 g is 34-65%. Cmax is achieved in 2-2.5 hours and is 22-32 µg / ml.

Distribution and metabolism

Fosfomycin trometamol does not bind to plasma proteins, dissociates in the body to fosfomycin and trometamol (does not possess antibacterial properties) and is no longer metabolized, it mainly accumulates in the urine. When taken in a single dose of 3 g in the urine is achieved a high concentration (from 1053 to 4415 mg / l), 99% bactericidal for most common pathogens of urinary tract infections. BMD (128 mg / l) is maintained in the urine for 24-48 hours (which implies a single-dose course of treatment).

T1/2 from plasma - 4 hours. Excreted unchanged by the kidneys (up to 95%) with the creation of high concentrations in the urine, about 5% - with bile.

Pharmacokinetics in special clinical situations

In patients with moderate decline in renal function (CK> 80 ml / min), including its physiological decline in the elderly, T1/2 fosfomycin is slightly lengthened, but the concentration in the urine remains at a therapeutic level.

Release form, composition and packaging

Granules for the preparation of oral solution white, with tangerine smell.

Auxiliary substances: tangerine flavoring, orange flavoring, saccharin, sucrose.

2 g - Multilayer laminated bags (1) - packs of cardboard.
2 g - Multilayer laminated bags (2) - packs cardboard.

Dosing regimen

For adults the drug is prescribed 3 g 1 time / day. The course of treatment is 1 day. If necessary (for severe or recurrent infections, the elderly), it is possible to re-take the drug in a dose of 3 g after 24 hours.

In order to prevent infection of the urinary tract during surgery, transurethral diagnostic procedures, the drug is taken at a dose of 3 g 3 hours before the intervention and 3 g 24 hours after the first dose.

Children over 5 years old the drug is prescribed in a dose of 2 g only once.

When prescribing the drug patients with renal failure reduce the dose and increase the interval between doses.

Before taking the granules dissolved in 1/3 cup of water. The drug is taken 1 time per day on an empty stomach 2 hours before or after meals (preferably before bedtime), after emptying the bladder.

Side effect

Co side of the digestive system: nausea, heartburn, diarrhea.

Other: skin rash, allergic reactions.

- acute bacterial cystitis,

- acute attacks of recurrent bacterial cystitis,

- bacterial non-specific urethritis,

- Asymptomatic massive bacteriuria in pregnant women,

- postoperative urinary tract infections,

- prevention of urinary tract infections during surgery and transurethral diagnostic studies.

Contraindications

- severe degree of renal failure (CC) Another 14 doctor reviews

An effective drug with the rapid development of the effect in acute cystitis. Side effects were not observed. Unfortunately, the drug is widely used for self-medication, which causes the development of resistance of the pathogen, respectively, reducing the effectiveness of the drug during repeated use. Easy to use.

A good antibacterial drug with a convenient dosing regimen, but more suitable for the treatment of an episode of newly developed cystitis.

The rather high cost, convenient dosage regimen and sufficient fame of the drug increase the risk of unreasonable use in cases of self-treatment by patients.

Only for the treatment of newly developed cystitis.

An excellent drug for the treatment of lower urinary tract infections, the drug of choice for emergency cases when you need to fast it before a scheduled operation. Tolerability is excellent; no side effects have been observed for the entire time of use. I recommend this drug for the treatment of acute uncomplicated cystitis and urethritis.

The drug of choice for newly diagnosed acute uncomplicated cystitis! Works well, quickly relieves symptoms, good tolerance!

In subsequent inflammations of the bladder almost 60-70% is not effective!

Low incidence of side effects. Very often, patients without a doctor's recommendation drink it when they want, and how much they want!

The drug is recommended as a first-line therapy for acute cystitis.

Indications for use of the drug are exhausted by acute cystitis. The drug should not be used for recurrent cystitis and exacerbations of chronic cystitis.

The drug is unreasonably widely used in the form of self-treatment and treatment of the recommendations of pharmacy employees. Associated with this is the increase in resistance (resistance) of infectious agents to the drug, and accordingly a gradual increase in the number of cases of no effect on treatment. This drug should be taken only on prescription. In no case should not be used independently with frequent recurrent cystitis.

Fosfomycin is a first-line drug for the treatment of acute cystitis. Convenient reception mode. A quick and lasting therapeutic effect occurs after a single dose of the drug. Side effects in my practice was not noted. Well tolerated by patients.

The high cost of the drug.

Allergic reactions are possible.

The drug of choice in the treatment of newly developed acute cystitis. Works well with symptoms. On the first day of the reception almost completely removes the manifestations of cystitis. The method of reception is also convenient for patients.

Ubiquitous independent reception at the manifestation of the disease, due to the recommendations and good performance. However, practically does not work in cases of exacerbation of chronic cystitis. Subsequently, patients are treated with an erased form to a doctor.

It is worth noting that many doctors according to the last recommendation, double the duration of the reception for acute events, to increase the effect (3 g 1 time per day for 2 days).

In my practice, I use Monural as an emergency medicine to treat bladder inflammation (cystitis, pyelocystitis). The drug has a good sensitivity for intestinal infections. One sachet is enough to relieve the acute manifestations of bladder inflammation. On the eve of summer and trips to the sea, I recommend to have it with you.

A good antimicrobial drug for the treatment of the first and possibly repeated episode of acute cystitis. Easy to use, low antibiotic resistance causes the widespread use of this drug as a first-line drug for the treatment of acute, uncomplicated cystitis, low incidence of side effects.

The first choice for uncomplicated, first developed cystitis. Almost immediately removes unpleasant symptoms, has no side effects and is quite easy to use. It is also possible for the treatment of infections IMP in pregnant women.

In some cases it does not work at all. Ineffective in chronic inflammatory diseases, symptoms can be removed, but does not solve the problem, and relapses of the disease occur quickly enough. The high cost of the drug.

It is sad that the drug is often used without a doctor's prescription on the advice of a pharmacy. Given the relatively high cost of the drug and limited indications for use, taking the drug only on prescription.

I have never seen any side effects. Perhaps lucky, but the fact remains. Efficiency - 70-80%, which, IMHO, is associated with the periodic participation of Ureaplasma sp. in the development of acute cystitis. Compliance - 100%. Value for money pleases.

The ideal first-line drug for the treatment of acute uncomplicated cystitis.

This drug is sometimes used in my medical practice. Liked: 1. Quick action, excellent result. 2. Single use. 3. When gestational pyelonephritis is possible, it can be prescribed during pregnancy. 4. Well helps with acute cystitis.

Did not like: 1. The drug is not the cheapest

In some cases, a single dose relieves inflammation in the bladder. Side effects are minimal.

Quite often, the effect of the application is absent.

Monural is actively used in the treatment of acute uncomplicated cystitis. Unfortunately, quite often does not live up to expectations. It is important to follow the rules of admission. Drink at night and try not to drink liquid before bedtime.

It is well tolerated, side effects in the form of urticaria and scheduling phenomena are extremely rare.

Monural has worked well for the treatment of uncomplicated lower urinary tract infections in young patients with newly developed acute cystitis, for example. As a rule, the effect occurs the next day, but sometimes a single use is not enough. Convenient as an emergency if the illness found in travel.

In my opinion, uncomplicated lower urinary tract infections in women can be treated with Monural, but when it comes to complicated recurrent infections, then there are less expensive and equally effective alternatives.

Patient testimonials about monural

Cystitis was ill a month ago. My disease is not chronic. It was night time and going to the doctor was not an option. I went to the pharmacy, and the pharmacist advised Monural, 3 g. In a sachet. I prepared according to the instructions and took it once. Unfortunately, tomorrow thrush thrush, as "Monural" was a strong antibiotic. Symptoms of cystitis disappeared, but after treatment the thrush began to appear again. The interval between the first cystitis and the second is a week. I went to the doctor. It turned out that for the first time Monural did not completely eliminate the disease, but only suppressed the symptoms. And by that time the infection had reached the ureters and struck them strongly. Subsequently, we had to pass tests for infections and the state of microflora in the genitals. The doctor wrote a treatment with Digran and several other drugs. I recovered a second time without thrush and will no longer apply to Monural. Helps instantly, but temporarily.

For several years there were no attacks of cystitis at all, but this summer, unfortunately, he again reminded of himself. After a couple of days of torment, I still went to the urologist, who prescribed the Monural for me. The drug is quite expensive, but I can not say anything, it really helps, the main thing is to fully follow the instructions. The very next day I forgot to think about the pains. But there is one significant but, unfortunately, I did not pay attention to the side effects in the instructions, so I was not ready for them. It is quite a negative effect on the digestive tract. Despite its very fast and effective effect, I personally next time will draw attention to a drug that is more harmless in its consequences.

A few years ago, I faced the most terrible (since I follow my health and rarely get sick at all) a disease - cystitis. Then, at the very first symptoms, I went to the doctor and prescribed "Monural". First, it worked right away, instant relief came. Secondly, it inspired confidence in the drug that this antibiotic does not affect the gastrointestinal tract, but enters directly into the bladder and for a long time, even when you think that everything is over, the drug fights with microbes and is eliminated naturally. There were no side effects, gastrointestinal disorders, too, and for themselves the name of the drug recorded. And now, after more than 6 years of careful and caring attitude to myself, I again earn cystitis, only the situation is 100 times more difficult, I am in nature so far from civilization that when I managed to get to a modern pharmacy, my urine becomes muddy and blood appears and pain simply intolerable, and here the Monural begins to act, not as quickly as the last time, relief came gradually, on the third day it became quite good, but the picture repeats on the sixth day, and since it can be re-accepted, accepted. The day passed and the symptoms did not return. The drug helps and tastes good.

Once I happened to get cystitis. As usual, in the hope of healing, I looked for a lot of drugs that could help me, but I could not find a sufficiently effective remedy. And then the doctor advised me on a medicine like Monural. I, already despairing, doubted its effectiveness. Began to apply, and suddenly I began to feel light, and after a day everything was gone. The truth is the only minus "Monural" is the great value of the product. From the pros: I did not feel the side effects and particular discomfort during the application. In general, "Monural" I was very much rescued and pleased, now he is always at my fingertips.

Faced with the use of this drug at the beginning of pregnancy, did not know about it at that time, breastfed the first child. She took "Monural" because of cystitis was urinary retention for 3 days, the appointment was made by the urologist, said the bag was taken once. It helped a couple of hours after admission. For lactating this drug is dangerous to stop lactation. Restore lactation failed. A breastfeeding specialist said, the reason is in the preparation, pregnancy does not affect lactation.

For the first time in my life I ran into cystitis. Advised "Monural". Excellent drug, at night drank a bag, in the morning as new. It is not cheap, but it is worth it! More such drugs. I personally had no adverse reactions.

He advised the doctor to try this drug. The symptoms went away literally in a day and a half. Very good drug, really effective, let's say. The price, yes, seems a little expensive, but the effect of it is much better than that of many other antibiotics. Side effects from the drug is not experienced. In general, in my opinion, an effective tool.

During pregnancy, faced with such an unpleasant illness as cystitis. Accordingly, there can be no talk of any antibiotics! The doctor advised to drink "Monural" just one bag and plus another medicinal drug to drink in for a week or two! I can say that after a day it became easier - unpleasant symptoms, such as stinging and pain during urination, disappeared. A week later, she passed a urine test according to Nechiporenko! I didn't have any sticks there, and the cystitis hasn't bothered me for a long time. Good medicine, but expensive.

"Monural" helped me a little. A day has passed, the pain has become weaker, but remains. A bruise in the form of diarrhea. Cystitis is acute, uncomplicated, without fever.

I bought this drug, they all praise it very much, the price is high, of course, but I decided to try it, this drug did not help me, I got more side effects from it than the result of treatment.

In addition to a positive review, I can’t say anything, unfortunately, I often suffer from cystitis, and this means for me is just a rescue, and very fast, I drink at night and in the morning as "new." The only drawback for me personally is the high price, but it's worth it, of course. I have tried many remedies, and this is the most effective medicine.

After the second episode of cystitis, I was afraid to drink antibiotics as such: I tried too much, and resistance to them arose. My medical colleague advised Monural. Especially bribed his one-time use, despite the biting price. As a result, in two days all the symptoms really went away and, pah-pah, did not appear again! He, by the way, has a pleasant taste, with an orange tint, so that there will be no unnecessary torment when used.

There was acute cystitis with turbid urine and blood, terrible pains. The pharmacy advised Monural. It has passed, but not immediately, for two days gradually. But suddenly other non-related symptoms disappeared - long-term burrs on the fingers did not heal, the smell also passed from the mouth, from which I concluded that it has a general effect, and not only on the urinary system. There were no side effects. And then bought again, decided to coincide with the common cold. I remember how it helped. But analogue, I do not remember the name. There are side effects in the form of soreness. Here I read here, it turns out 36-48 hours. It will be flattening. From monural it wasn't like that. But again, a miracle! Already two weeks terribly sick leg and waist. После того, как по женской части ушла киста, и врач сказал, это у меня от кисты часть жидкости куда-то там попала.Well, I suffered for two weeks, I couldn’t get on my foot in the morning. Two uzists different in gynecology said - neurology, a cyst nothing to do with. And the pain in the clinic does not go -23 February, then the weekend, I bought the monural while the leg and lower back went through 4 hours. Draw conclusions.

For the first time he got cystitis, was treated with this drug. She took once as prescribed by a doctor. Symptoms of cystitis (constant urge to urinate, cutting around the bladder) disappeared after a few hours. Two weeks later, cystitis manifested itself again and became chronic. She was treated with another antibiotic for 10 days. Another time was treated with "Monural", but already with a double reception, cystitis was completely and for a long time. If the form of the disease is acute (for example, also with blood during urination) or chronic, "Monural" is unlikely to help. Plus the fact that it is convenient to take it on trips, and, in my opinion, it is allowed to take during pregnancy (in the second and third trimester).

Great medicine. It just saved me from pain in almost two hours. Now you can safely visit the urologist, as with pain and the frequent urge to do it is difficult. And even more so wait for the analysis on the bacteria.

"Monural" is an excellent drug in the fight against inflammatory processes of the urethra, as well as with cystitis, which sometimes from overcooling occurs in me and causes a lot of inconvenience. The powder is very effective and has a pleasant taste and smell, one course is enough to cure the disease.

Hello! I would like to tell you about my experience with the use of the drug "Monural". Many reasons were the basis for its use at this time, but if you combine them all into one name, it is an infection that originated in the genitourinary system. Diabetes mellitus and a fairly long experience of the disease have become catalysts of chronic pyelonephritis. Canephron or Urolesan is a weak prevention method and no more. If inflammation starts, you need Monural. To me and to all whom I advised him, he helped absolutely and, most importantly, instantly. Monural is a broad-spectrum antibiotic, fosfomycin, but it is very simple to operate. I accept it as follows: I go to the toilet before going to bed, after which I stir the contents of one packet in half a glass of warm water, drink and fall asleep. In the morning I go to the toilet, sometimes feeling cramps when urinating, and repeat the procedure on an empty stomach, that is, I dissolve the contents of one packet in half a glass of warm water and drink. The taste of “Monural” pleasant, orange-lemon. The color of the powder is white. It dissolves well. Symptoms will go away on the same day. "Monural" - this is the drug that is worth the money.

The last time I was treated with "Monural", yes, he helped, but literally immediately began severe diarrhea, which, three days later, barely managed to stop.

I am 8 months old, found E. coli in the urine, prescribed "Monural". I drank as expected, at night, according to the instructions. After 4 hours I woke up. The most terrible diarrhea, straight water, vomiting. All day diarrhea, today is the second day after admission. Diarrhea, but at least nausea has passed. I hope that at least help, and that the baby does not harm. So consider this my spoon of tar in your barrel of honey.

A month ago, pains appeared during urination, she was treated with "Urolesan" and "Kanefron" - it did not help, her kidneys started to hurt, the tests just awful came. They decided to take me to the hospital for stabbing with antibiotics with a bunch of side effects. They say that self-medication is dangerous to health, but my situation has proved the opposite. If it were not for reviews on the Internet, then my whole fifth point would be bruised. I bought Monural, drank a bag and felt healthy the next day, and there is no hint of cystitis. Not only did it help at once, it also has a divine taste. I drank with pleasure, there were no side effects.

I will insert my 5 kopecks into the money-box of the Monural drug. I have drank a bunch of medications for 5 years of treating my cystitis “perpetual”, but to no avail - anyway, after a month or two, cystitis returned. I changed the doctors, probably, ten, but I don’t have much sense either - everyone prescribed something of his own, antibiotics that I drank - I won’t list them on the fingers of both hands. "Monural" I was assigned a new, young doctor. I honestly didn’t really hope, but when on the second day after the reception I was able to go to the toilet without pain, I was very happy. Then other signs of cystitis are gone. So “Monural” helped me, now I don’t even think about thorough cystitis, just like a bad dream that lasted 5 years!

When I was pregnant in the fifth month, they found E. coli in the tests. As a result, cystitis and kidney aches terribly, already could not walk. In addition to herbal medicine, monural was prescribed. I was very afraid to accept, because I didn’t know how it could affect a child. But the doctor said that in this case, without an antibiotic in any way. And if the infection spreads even more, it will only get worse. In the end, I drank two such packages for a course of treatment. He really helped. Cystitis was cured, and the baby was born healthy.

I always thought that cystitis is only from hypothermia, but in fact the cause is E. coli, so you need to be treated very necessarily and very seriously so as not to get a cystitis in a chronic form. So, you should start with a visit to the doctor, after the examination, he will prescribe treatment. I was recommended to improve immunity (well, I know how vitamins, a correct lifestyle, more fruits and vegetables, etc.) and treat cystitis with the help of the drug "Monural". “Monural” helped me very quickly, literally the next day, it no longer tormented the pain, it ceased constantly to want to go to the toilet. In general, I am glad that everything ended so quickly and well.

Chronic cystitis has been haunting me for 8 years already, I have drunk a lot of drugs - both antibiotics and drugs of national origin, but perhaps it was just a quick result from the monural. He was discharged to me by his doctor, drank a bag for the night and slept, in the morning the pain disappeared as if by hand. But still I took a course of antibiotics after drinking monural, although he took off the hellish pain and cracks almost immediately. Monural is not a panacea for cystitis, but as an ambulance he approached me, a worthy drug.

This medicine is just super! I rarely get sick, but once I ran out into the street with wet hair, in thin tights and a short skirt. Here and descended for the first time in the life of cystitis. None of the drugs from the pharmacy helped; they bought chamomile herb and tea for cystitis. In vain the money spent, and with cystitis especially not tolerate. I learned from friends about "Monural". Even pregnant women are prescribed by doctors. The price for one bag is not small, so it remains for me to guess whether it will help or not. One bag of 5 dollars. The remedy helped the first time. This is an antibiotic that relieves all symptoms of the disease. "Monural" helped for an hour and the cystitis was gone completely.

This drug is always in my bag. Cystitis appeared on the eve of the exhibition, I called the doctor, she said that only he could handle it. And really saved. It became easier after two hours. Only for girls who have read positive reviews and are abusing self-medication, it is important to know that this is an emergency symptom relief, but not a cure for inflammation. Be sure to see a doctor and drink the prescribed medication.

Good, but very expensive medicine. It does not immediately help, of course, but much faster than any other remedy for cystitis. Side effects are not felt, although the instructions are described. It is very important that the medicine has a rather pleasant taste and smell, since I cannot drink something sugary sweet. After other medications, cystitis returned with time. Monural is not one of those, fortunately. About the price - expensive, no doubt. I heard that you can find a cheaper equivalent, but did not dare, because this sore really got me. I advise you to spend time and buy monural, than to suffer and buy something cheaper.

Monural is an excellent drug. At one time, he saved him from a sudden onset of cystitis at the height of the session. I put an end to the successful completion of tests and exams, since absolutely nothing was able to do. On the Internet in the forums advised Monural. I could hardly believe that one pill, in which then it was still released, would be able to alleviate these sufferings. And I was extremely surprised - after three hours I felt fine and was happy about the happiness when nothing hurts. Monural drank again after that incident - a year later the cystitis began again, but Monural also quickly put on his feet.

Very good tool. I used to save them before, and there is still one nuance that few people know about - very often cystitis occurs after sex without condoms, especially if a small amount of lubricant is released (for example, during menopause). In general, if you use a good lubricant, you can avoid all this. The only lubricant should be of high quality, not cause allergies, the same montavit gel is suitable, a great lubricant.

Faced this medicine during the third semester of pregnancy. Already practically before the birth, a general urinalysis was given and a protein was found. The urologist advised to drink only one sachet so that the tests were good. And indeed, a miracle happened. After I cut Monural, the next urine test showed that I was fine.

The doctor prescribed the monural to the eldest daughter (she is already an adult with me), because she suffers from cystitis several times a year. Indeed, the monural helps her, and the inflammation quickly passes from him. But repetitions of inflammation occur as often as before. There is no time to go to the doctor, so we take monural every time. Although it is probably wrong.

This medicine literally saved me. We went to rest on the sea, and one day the cystitis began. The pain and pain during urination were very strong, as well as crying. Cystitis, I do not suffer at all, but here it is, and it is not clear what started. I had to contact a local urologist, who prescribed monural. I couldn’t even believe that just one sachet can help, usually medicines are taken in courses for several days. But it really helped. She spread the bag with water, drank it overnight. In the morning the cracks were quite tolerant, by the evening everything went as the doctor had promised. Indeed, some kind of "miracle" drug.

Drug monural

Monural - modern antibiotic broad-spectrum, which is used in the treatment of inflammatory diseases of the urinary tract. The active ingredient of Monural - fosfomycin.

Almost immediately after administration, this drug is easily absorbed from the digestive tract and quickly accumulates in the urine. After 2 hours, it reaches the highest possible concentration, sufficient for a detrimental effect on microorganisms.

The drug is effective against most gram-positive and gram-negative bacteria, including those resistant to other antibiotics. Monural is in the body for up to 48 hours, after which 90% of the drug is excreted by the kidneys and 10% by the intestines. Two days is enough to achieve a stable therapeutic effect.

Monural treatment

How to take Monural?
The contents of the bag should be dissolved in 1/3 cup of water. Drink 2 hours before a meal or 2 hours after a meal, as taking the drug with food slows down its absorption in the body. Take the medicine preferably at night after the bladder is empty. One sachet per course of treatment is usually sufficient.

You can not take Monural at the same time as Metoclopramide, as the concentration of fosfomycin in the plasma and urine may decrease, the effect of the drug treatment will not be.

Patients suffering from diabetes, it should be borne in mind that the drug includes sucrose.

While taking the drug can not drink alcohol.

Monural Dosage
The standard dosage for adults is 3 g daily.

In some cases, the doctor may prescribe a second medication every other day:

  • Recurrent bacterial infections,
  • old age of the patient
  • severe course of the disease:
  • no result after the first medication.

For the prevention of urinary tract infections in the diagnosis or urological intervention, the drug is taken twice: 3 hours before the planned intervention or study, and 24 hours after the first dose.

Monural should be administered with caution to patients with renal insufficiency. It is recommended to either increase the interval between doses of the drug, or reduce the dose.

Monural during pregnancy and lactation

During pregnancy, women often develop cystitis. Monural best suited for the treatment of cystitis in pregnant women, while not causing pathology in the fetus.

Monural's huge advantage is its single dose, while the treatment with other antibiotics lasts at least 5-7 days. The next positive point is that the medicine has practically no contraindications and side effects. It is usually well tolerated by patients.

But to appoint a single dose of Monural to a pregnant woman can only be a doctor after a thorough examination. Since, although there has been no targeted research on the effect of the drug on the development of pregnancy, it is known that fosfomycin can overcome the placental barrier. Therefore, Monural prescribed for pregnant women only for health reasons or in cases where the effect of treatment far exceeds the potential risk to the fetus.

It should be noted that women who have had cystitis before, before pregnancy, Monural can not help. It will have to be combined with other drugs.

In the first trimester of pregnancy, medication, including Monural, is generally undesirable. It is during this period that the active formation of the internal organs of the baby takes place.

In the period of lactation, when prescribing a nursing mother Monural, breastfeeding for the period of treatment will have to stop, because fosfomycin may pass into breast milk.

Monural cystitis

Monural is great for treating cystitis. It has been proven to be effective against most bacteria that cause this disease. Moreover, in addition to bactericidal properties, the drug reduces the ability of microorganisms to be fixed on the walls of the bladder.

Treatment of acute cystitis should begin immediately to prevent the transition of the disease to the chronic form. If exacerbation of chronic cystitis is necessary to take an antibiotic on the first day.

Monural is used for cystitis once, in the above dose (see Monural dosage).
More about cystitis

Drug reviews

On the Internet you can find many reviews on the use of Monural. Most of them are positive, but occasionally negative responses can be found.

In positive reviews, the efficacy of the drug is highly appreciated with only a single dose, no side effects. Treatment Monuralom most patients call very convenient, and the cost - acceptable.

Negative feedback mentions that the drug “does not help”, but does not say in what situation and when Monural was used, whether the dosage was observed, whether the doctor prescribed the medicine, or the patient decided to self-medicate.

Description, composition

Monural is among the antibacterial agents with a large range of action. In the role of the base is the substance fosfomycin, preventing reproduction, as well as the rapid development of bacteria.

This ensures their complete neutralization. This reaction occurs due to the fact that the enzyme is destroyed. It is necessary for the flow of the full formation of the cell walls of living organisms.

This product has another positive feature. The particles are attached to the mucous, they do not allow pathogens to change the structure. This happens against the background of strengthening immunity.

The effectiveness of the drug

The speed of action is the main distinguishing feature of the powder. The developers argue that to obtain the optimal effect of a one-time reception of funds.

Thanks to this, an excellent therapeutic effect will be achieved. In extreme cases, repeated administration of the medication is allowed after a short period of time.

In this case, the drug is absolutely safe for health. Practice shows that patients tolerate it well.

The effectiveness of the therapy is ensured by the fact that microbes have not yet developed immunity to active substances.

Advantages and disadvantages

Before you begin treatment with the drug Monural, it is recommended to evaluate the benefits, as well as the negative features of the drug.

Despite the effectiveness and safety of the product, it can be taken only with the permission of the attending physician. At the same time, the therapeutic zones should be observed, as well as the treatment periods chosen by the doctor.

The advantages of the drug:

  • the composition is easily absorbed. At the same time, the mucous membrane of the digestive organs is not irritated,
  • To get the effect, you only need to take 3 grams of the therapeutic composition,
  • the antibiotic is carefully diluted in liquid before use (the drunk water thoroughly flushes the bladder),
  • The drug eliminates the symptoms that distinguish acute inflammation. The tool is effective even for those diseases that are accompanied by the presence of blood in the urine.

As for the deficiencies, they also need to be considered in the treatment process. Если продукт принимать не в соответствии с существующими правилами, эффективность его действия будет минимальной.

Еще один минус — продукт выводят почки. When diseases of this organ are present, the use of Monural is prohibited. To obtain an optimal effect, the bladder should be emptied before use. In certain situations, this is very problematic (especially in dysuria).

When is monural prescribed?

The main area of ​​application of Monural is the treatment of bacterial cystitis and urethritis (inflammation of the urethra). Monural 3g powder is used in the acute course of the disease or is prescribed as part of the complex treatment of chronic infectious processes in the urinary system. Use of the drug is justified in case of acute recurrent attacks of the disease. In addition, Monural is prescribed in the following conditions:

  • massive bacteriuria pregnant, asymptomatic,
  • urinary tract infections in the postoperative period.

In order to prevent the drug prescribed after surgery on the urinary tract or during therapeutic and diagnostic procedures (when setting the catheter or cytoscopy).

Monural with the same efficiency is used in both women and men. Reviews of the use of Monural in cystitis show its exceptional effectiveness and fairly high safety. The drug is allowed to use at almost any age, and its use is allowed in pregnant and lactating women, since there is no negative effect of the active substance on the fetus or infant who is breastfed.

Treatment of Cystitis Monural

Monural is recommended to be taken on an empty stomach, after having dissolved one bag of medication (3g) in a third of a cup of warm water. This should be done in the evening (before bedtime), two hours after the last meal and after emptying the bladder. A single dose of the drug is enough to eliminate the symptoms of cystitis and destroy the infectious agents.

In the recurrent form of the disease, the doctor may recommend re-taking Monural a day after consuming the first dose of the antibiotic. The same treatment regimen is used for elderly patients. If monural is prescribed for prophylactic purposes, a single dose of the drug is taken 3 hours before the diagnostic procedure or operation or 24 hours after the intervention. In patients with renal failure

How much to drink Monural with a relapsing course of cystitis or urethritis depends on the severity of the disease. The need for re-use of the drug becomes clear one day after the first dose. If the symptoms of the disease persist, you need to take another dose. You can take the drug up to three times.

In patients with renal insufficiency, the treatment regimen needs to be adjusted - reduce the dose of the drug and increase the time interval between taking the solution. Sometimes this drug is prescribed for pyelonephritis for the prevention of descending infection. In this case, Monural and pills against the causative agents of the underlying disease are taken at the same time.

Using Monural during pregnancy is acceptable, but under the supervision of the attending physician. The drug does not penetrate the placental barrier, so it is completely safe for the baby, but a hypersensitivity reaction may occur to it (even if it was not before the pregnancy). Therefore, it is best to trust your gynecologist and strictly follow his recommendations.

Adverse reactions

Adverse reactions while taking Monural can be manifested by the appearance of skin rashes (in individuals with hypersensitivity) or disorders of the digestive system (nausea, heartburn, vomiting or diarrhea). If such symptoms are pronounced, then it is advisable to replace Monural with analogues that do not cause such adverse events. In less severe cases, to eliminate dyspepsia, it is enough to increase the amount of fluid consumed.

An overdose of the drug is extremely rare. If it does occur, the patient is prescribed forced diuresis - an increase in the amount of fluid consumed along with the intake of diuretic drugs. There is no specific antidote, the need for hospitalization or resuscitation usually does not occur.

FAQ

  1. How much to take Monural? In most cases, a single dose of the drug. If necessary, the doctor may recommend a three-time intake of powder at intervals of one day (in adults). Children reuse is not allowed.
  2. Can I take Monural with thrush? If thrush is combined with bacterial cystitis, then a combined treatment is possible under the supervision of a physician. In other cases, the use of antibiotic can increase the manifestations of thrush.
  3. Why Monural with pyelonephritis? When inflammation of the renal pelvis there is a risk of a downward infection - the introduction of pathogens with a stream of urine into the bladder and urethra. To avoid this complication, the doctor may prescribe Monural.
  4. Monural did not help what to do? Take the medicine again. If, after repeated use of the antibiotic, there is no improvement, consult a doctor. Most often, the lack of effectiveness is due to the fact that cystitis is non-bacterial in nature or the infectious agents are insensitive to the active substance.
  5. Does Monural help men? The drug is equally effective in cystitis, urethritis and bacteriuria in both sexes. The dosage for men and women is the same, the method of application too.
  6. How to use Monural in adolescents? Children's Monural can be used up to 18 years, that is, it is permissible to appoint adolescents. In some cases, the doctor may individually select an adult form of the drug for treatment.

Monural has a number of structural analogues, which are based on the same active substance - fosfomycin. These include drugs:

In case of intolerance to fosfomycin, the doctor may select a preparation based on another active ingredient, but with an identical therapeutic effect, for example:

  • Nitroxoline,
  • Nolitsin,
  • Zenix,
  • Amizolid,
  • Dioxidine
  • Sanguirythrine, etc.

The drug is dispensed from pharmacies without a prescription, despite the fact that it refers to antibacterial agents. Monural price averages from 380 to 470 rubles.

The shelf life of the drug with intact packaging - 3 years, you need to store in a dry place out of the reach of children and pets, at room temperature.

Application Reviews

Reviews of patients about Monurale indicate high efficacy and speed of the drug. Especially noted is the possibility of a single dose of the drug, which, unlike other means of cystitis, used for a longer period of time, is a significant advantage. Among other advantages, mention is made of a significant relief of the condition shortly after taking the solution, the absence of dangerous side reactions and the minimum number of contraindications.

Review №1

I recently got from the cottage home on the bus, I had to walk to the bus stop in the rain, I got wet and cold. Not only did it come down with fever, runny nose, and sore throat, it also aggravated chronic cystitis. She used to go to the toilet often, but the urine was excreted in a small volume, while there were strong cracks. AT

Racha prescribed a course of treatment for colds, and from cystitis she advised to drink Monural according to a special scheme. It was necessary to drink one dose of the drug in the evening before bedtime, and a day later to take the same amount of medication again. Monural is a fairly expensive drug. In the package one bag of granules (3g), at one time.

For treatment, I had to buy 2 packs at once. But the result of the application is excellent. Within a few hours after taking the first dose, the discomfort, pain and pain disappeared. And on the third day, I completely forgot that I had an exacerbation of cystitis.

When cystitis is the best drug - Monural. It acts very quickly, and it is enough to take a dose of the drug only once and soon all the symptoms of the disease disappear. The drug is produced in the form of white granules, before taking them must be dissolved in a small amount of water. It turns out the solution with a pleasant sour taste and smell of orange.

This remedy rescued me more than once, while Monural does not cause any side effects and is considered one of the safest remedies for cystitis. It can even be taken by pregnant and lactating women.

What is Monural

Anti-bacterial drugs based on phosphoric acid, which also includes Monural, have a wide spectrum of action, quickly eliminate the symptoms of urinary tract diseases and promote healing. This drug is considered relatively safe. It does not cause cross-drug resistance (reduction in the effectiveness of treatment due to the use of similar in composition means), often used in pediatric practice.

Unlike other bacteriostatic agents, Monural with cystitis acts purposefully. If some drugs can only slow down the growth and reproduction of pathogenic flora, this antibiotic provokes cell death. The mechanism of action of a highly effective drug is realized due to the ability of the active component to disrupt the production of protein in the cells of the bacteria, the result is that the development of the microorganism stops, the bacteria die.

Release form and composition of the drug

The medicine is made in the form of white granules with a characteristic citrus smell. The powder is packed in paper bags, inside covered with a polyethylene sheath. There are two types of medicinal product on sale, the difference of which lies in the volume of packaging: two-gram sachets are intended for the treatment of children, three-gram packages for adults.

The active active ingredient is fosfomycin trometamol. The component is a structural analogue of phosphoenol pyruvate, which ensures high efficacy of the drug in relation to gram-positive and negative microorganisms. As auxiliary substances are:

  • saccharin 0,016 g,
  • sucrose 2.213 g
  • Tangerine flavor 0,070 g,
  • flavor amplifier "orange" 0.070 g

The mechanism of action of the antibiotic

The drug has a broad spectrum of antibacterial activity against most gram-positive and gram-negative microorganisms. The active substance acts as a protein synthesis blocker that makes up most of the bacterial cell walls. Monural's bactericidal effect in cystitis is especially high at the initial stage of the disease.

The specific effect of fosfomycin is based on its ability to inactivate the enzyme enolpyruvil transferase, thereby eliminating drug resistance with other antimicrobial agents. In the course of experiments conducted in vitro outside a living organism, synergism (the action of drugs in one direction) with pimemidinic acid, amoxicillin, cephalexin was established.

Through how many Monural

The active substance is absorbed into the systemic circulation within one hour. Therapeutic concentration in plasma is reached in 2-2.5 hours, in the urine in 4-5 hours and remains so for up to two days. Monural cystitis should be taken once in the amount of 1 three-gram sachet. Patient reviews indicate that relief occurs 2-3 hours after taking the solution.

Indications for use

To date, Monural with cystitis is recognized as one of the most effective means. The results of numerous studies conducted by leading world clinics have shown the effectiveness of the agent in treating various kinds of urological problems in a single-dose manner - this is the “one pill for cystitis” patients dream of. According to doctors, the only drawback of the remedy is the lack of effectiveness in the treatment of chronic diseases of the urogenital area.

According to the official instructions, it is necessary to take the powder:

  • in the treatment of infectious lesions of the urinary tract of the acute stage - urethritis in men, cystitis in women,
  • when asymptomatic bacteriuria is detected (when bacteria are harvested more than 105 per 1 ml in the urine), including cases when a pregnant woman is diagnosed,
  • in urethral syndrome - a phenomenon that is accompanied by symptoms of inflammation of the urethra, severe pain when urinating,
  • to eliminate the complications of infectious genesis arising after surgery on the pelvic organs,
  • for the prevention of infection during transurethral diagnosis.

Monural is an antibiotic or not

The main component of the powder - fosfomycin trometamol belongs to the class of antibiotics of phosphonic acid derivatives. Its action is aimed at the destruction of 99% of bacteria by influencing the production of protein in the cell membrane and preventing further exacerbation of the inflammatory process in the urogenital tract. The Medical Association has counted the class of the broad-spectrum antibiotic as drug Monural.

How to take Monural

To prepare the mixture, the pellets from the bag must be poured into a glass and filled with 100 milliliters of pure water. For effective absorption of the drug before taking the drug is recommended to completely empty the bladder. The last meal should be two hours before or after treatment. It is advisable to take the solution in the morning or in the evening before going to bed. Dosage, duration of administration are selected individually. A standard course of therapy is 1 day.

Please note that the use of Monural in case of cystitis is advisable only if the pathology was triggered by certain strains of harmful microorganisms, otherwise the treatment may become ineffective due to the fact that the bacterium was resistant to the fluoroquinolone antibiotic. Before using the medication, it is necessary to pass tests for bacposa in order to determine the type of pathogen and its resistance to the active substance.

For adults

For the treatment of diseases of the urinary tract in adults one-time use bags with a dosage of 3 grams. The solution is prepared immediately before administration. Storage of finished potions is not allowed. Instructions for use states that in order to prevent the infection from entering the urinary tract during surgery, patients need to take an antibiotic 2 times: 3 hours before the prescribed procedure and one day after surgery.

Monural for children

The antibiotic is considered relatively safe, because it is completely eliminated by the kidneys and does not bind to plasma proteins. The use of Monural for cystitis in children is permissible when they reach the age of five. A two-gram bag should be dissolved in 1/3 cup of warm liquid and given to the child in the morning on an empty stomach or overnight. In the absence of a positive therapeutic effect, repeated administration is not prescribed - it is advisable to select other types of antibacterial drugs.

Instructions for use in special cases

During the period of drug therapy of cystitis, it is necessary to consume a large amount of fluids, stop drinking alcohol, and follow a diet: remove salty, fried, smoked foods from the diet. Monural is a broad-spectrum antibiotic, so after treatment it is necessary to restore the microflora of the intestinal mucosa using probiotics. In special cases (during pregnancy, old age, kidney disease), the dosage and duration of treatment should be adjusted according to the description of the drug or the recommendations of the attending physician.

When a second antibiotic is needed

With recurrent cystitis, recurrence of urethritis symptoms or other infectious diseases of the urinary system caused by Gram-positive or Gram-negative bacteria, repeated use of Monural is allowed a day after taking the first dose of the antibiotic. A similar regimen is used to treat older patients.

Repeated antibiotic intake is necessary for transurental diagnosis. The regimen is 1 sachet of 3 grams three hours before the procedure and exactly 24 hours after the examination. With diagnosed cystitis, the need for re-use of Monural is determined in a day - if the desired effect has not been achieved, repeat the treatment. The instructions indicate that the maximum treatment ratio is 3 sachets.

With renal failure

Patients who suffer from renal dysfunction, it is necessary to reduce the dosage of the powder and increase the intervals between doses. Monural is not recommended to be taken too often with diagnosed pyelonephritis. With this type of disease, the antibiotic is used as an adjunct in combination with other drugs. The regimen, the course of treatment is chosen individually depending on the severity of the disease, history, patient complaints.

Interaction with other drugs

It is not recommended to take Monural with cystitis along with antibiotics of a similar composition due to the high risk of overdose. Excessive concentration of fosfomycin in the urine leads to increased side effects. If an overdose occurs, the patient is advised to go to the hospital. При комбинации с метоклопрамидом снижается концентрация фосфомицина в крови и моче, поэтому данное взаимодействие нежелательно.

pharmachologic effect

Обладает широким спектром антимикробной активности, оказываетбактерицидное действие.

Suppresses the synthesis of bacterial cell wall (in particular, its first stage).

Specific action fosfomycin manifested in its ability to inactivate enolpyruvil-transferase, which ensures the absence of cross-drug resistance and eliminates the likelihood of synergy with other antimicrobial agents (in vitro synergism with pimemidinic acid is observed, cephalexin, amoxicillin).

Description of the drug Monural

Monural antibiotic is produced in the form of characteristic smelling granules of white color. As an active substance in the product includes a derivative of phosphonic acid - fosfomycin. Being a structural analogue phosphoenol pyruvateThe substance is active against most Gram (+) and Gram (-) bacteria.

Pharmacodynamics

In vitro antibacterial activity of the drug includes most of the usual Gram (+) microorganisms: enterococci (including fecal), staphylococcus (including gold and saprophytic).

Also, Gram (-) pathogens are sensitive to the action of the drug: E. coli, citrobacter, enterobacteria, Klebsiella (including Klebsiella pneumonia), protei mirabilis, morganella moro, serration, pseudomonads.

In vitro means reduces adhesion (sticking) of a number of microorganisms on the urothelia.

Antibiotic treatment of cystitis

Cystitis belongs to the category of diseases, which, although they do not pose a threat to life, are still capable of causing a lot of suffering to a patient Symptoms of cystitis, having arisen once, subsequently, as a rule, come back again and again.

The drug Monural is antibacterial agent broad spectrum. Unlike bacteriostatic drugs that can only slow down the growth and reproduction of microorganisms, it provokes the death of bacteria.

The mechanism of action of Monural is realized due to the abilityfosfomycin disrupt the synthesis of the bacterial cell wall. As a result, cell development stops and the cell dies.

Today, Monural with cystitis is considered one of the most effective means.

The results of studies that were conducted in the leading clinics of the world confirm its effectiveness in diseases of the urological sphere (the one “cystitis pill” that most patients dream of) and the rapid achievement of a good therapeutic effect (it is enough to take the powder two times).

The antibiotic acts against cystitis pathogens, as well as against the majority of Gram (+) and Gram (-) microorganisms, which allows it to be used as an empirical therapy, that is, even before receiving information about the pathogen and its sensitivity to the drug.

Pharmacokinetic features Furomycin contribute to the creation of a long-term stable concentration of the active substance even after taking 1 single dose.

In addition, the substance is almost completely removed by the kidneys, which eliminates the likelihood of dysbiosis in the application of Monural. And taking the remedy by a short course allows you to avoid the development of resistance of pathogenic microorganisms to it.

The drug is distinguished by good tolerability and the absence of a negative impact on the development of the fetus, so the drug Monural from cystitis in women can be used even during pregnancy: in most countries it is one of the drugs of choice for treatment asymptomatic bacteriuria and UTI in pregnant women.

Instructions on how to take Monural with cystitis are as follows: for men and women, a single dose of 3 grams is shown, for children - 2 grams of the drug previously diluted in a third cup of water.

In severe cases, adults are allowed to repeat the drug in 24 hours at the same dose.

Use of the drug in pyelonephritis

For treatment pyelonephritis Monural is not used too often. However, the antibacterial effect of the agent is manifested not only in bladderbut all over urinary tract. And this is exactly what makes it expedient to use it even in case of pyelonephritis.

In such cases, the treatment regimen is selected individually, and the drug is used in combination with other drugs.

Side effects

Side effects of the drug can manifest as reactions from the digestive tract (diarrhea, nausea, heartburn, vomiting), as well as hypersensitivity reactions (skin rash, itching).

To eliminate unpleasant phenomena from the gastrointestinal tract, it is usually sufficient to increase the volume of fluid consumed.

How often can I take the drug?

To the question "How often can you drink Monural?"Doctors answer this way: the drug is taken only if there are symptoms of the disease, if the symptoms occur too often (once a month, for example), it is most likely a chronic form of the disease, and treatment in this case should be selected only on the basis of the results of the complex survey.

Additionally

Despite the abundance of information about the treatment of cystitis Monural tablets, you should know that neither pills nor parenteral dosage forms under the trademark Monural are not available. The only available form of the drug are granules for the preparation of potions for oral administration.

special instructions

Suction fosfomycin slows down while eating, because of what the drug should be used 2 hours before or 2 hours after a meal.

Sick with diabetes mellitus it is necessary to take into account that sucrose is a part of Monural granules. Its concentration in one two-gram package is 2.1, in a three gram package 2.213 grams.

The use of broad-spectrum antibiotics (including fosfomycin trometamol) can cause the occurrence of antibiotic-associated (including pseudomembranous) colitis.

Therefore, if a patient has severe diarrhea during the period of treatment or after taking Monural, consider the likelihood of this diagnosis.

If confirmed, appropriate therapy should be promptly prescribed. Peristalsis inhibiting drugs are contraindicated in such cases.

Analogs of Monural

Monural structural analogues: Fosmycin, Fosfomycin, Urofosfabol, Forterase, Espa-Focin, Cistoral.

The price of analogs of the drug in Ukraine - from 146 UAH.

Which is better: Monural or Nolitsin?

Nolitsin - this quinolone bacterial agent with a wide spectrum of action, which is used to treat infectious diseases of the upper and lower urinary tract(complicated or uncomplicated, occurring in acute or chronic form).

Indications for its use arepyelitis, pyelonephritis, cystitis, chronic prostatitisassociated with urological operations diseases of an infectious nature, neurogenic bladder, and nephrolithiasiscaused by sensitive to Norfloxacin (active substance Nolitsina) pathogens.

A course of treatment Norfloxacin It lasts - depending on the severity of the patient’s condition and the nature of the course of the disease - from 3-5 days (with uncomplicated cystitis) to several weeks (with chronic bacterial prostatitis).

Unlike Monural, Nolitsin cannot be used in pediatrics and in pregnant women.

Monural during pregnancy and breastfeeding

According to the instructions, during pregnancy, the use of the drug is possible if necessary.

The drug is used exclusively in urological practice, which eliminates the occurrence of cross-resistance with other antibiotics, meets the safety criteria, has proven microbiological efficacy and, in addition, has successful pharmacokinetic parameters.

Although studies in animals have not revealed that the drug can cause harm to the fetus, it should be remembered that even safe medications are undesirable in the early stages.

In the 2nd trimester and in the 3rd trimester, the medicine is taken according to the standard scheme: 1 sachet of 3 g and then another one a day after the first dose.

Reviews of Monurale during pregnancy confirm the effectiveness of the drug: with an uncomplicated form of the disease, as a rule, only one dose of the drug is enough to eliminate the symptoms and their causes.

If necessary, use during lactation breastfeeding should be stopped.

Monurale Reviews

Reviews of Monurale in the forums, as well as reviews of doctors about the drug, indicate the high effectiveness of the remedy in relation to the causative agents of UTI and its speed.

For example, reviews of Monurale with cystitis, allow us to conclude that the majority of patients feel a significant improvement within the first hours after taking the solution.

The undoubted advantages of the drug over analogues are the possibility of using a short course and the absence of serious side effects. At the same time, the duration of a relapse-free period after treatment with Monural is at least 6-12 months.

And yet sometimes patients go to doctors with a complaint: “The drug did not help, what to do?". If the effect is not noticeable after a single dose of Monural, you may need to take another single dose. If there is no improvement after this, it is necessary to exclude another reason for the occurrence of unpleasant sensations.

And, of course, in order to completely cure the disease and prevent it from becoming chronic, self-treatment should be avoided and specialists should be promptly contacted.

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