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Prednisolone in ampoules against shock conditions, edemas and inflammations

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Prednisolone (in Latin INN Prednisolonum) is a unique drug that is a synthetic analogue of the adrenal cortex. It has anti-inflammatory and anti-allergic effect. Pharmacological group - Glucocorticosteroids.

He also reduces the number of protein in the plasma and performs the synthesis of the protein that binds calcium. It acts as an auxiliary substance and stimulates the formation of cells in the bone marrow, retains water, phosphate and sodium, enhances receptor sensitivity, reduces the number of immunosuppressive diseases by reducing them. Another function is the enhancement of gluconeogenesis.

Composition, release form

The most common forms are ampoules and tablets. The first ones contain 25 and 30 milligrams and in 1 ml. They come in packs of three. There are also ampoules with 1 milliliter of suspension specifically for injection or injection. They contain 25 and 50 milligrams. In their packaging can be from 5 to 1000 pieces. There is also an ointment in the tubes, a solution and even eye drops. But the most popular pills in packs of one hundred.

For example, in one tablet from the manufacturer Nycomed and Gedeon Richter - 0.005 grams of prednisone, there are also such excipients as milk sugar, calcium stearate and potato starch.

How much is?

The above release form will cost the patient approximately 150 rubles, while a 1-millimeter ampoule will cost 100 rubles.

For what purpose, indications for use

It is prescribed for a list of diseases: collagenosis, rheumatoid arthritis, arthritis, asthma, leukemia, mononucleosis, neurodermatitis, eczema, allergy, adrenocortical insufficiency, anemia, pancreatitis, collapse and shock, conjunctivitis, blepharitis, inflammatory different departments eye and after eye injuries.

Analogs are cheaper

How to replace this medicine? The only more or less common analogues for this drug are called Decortin, Medrol, Deltason. Also in pharmacies you can find such a substitute as metipred.

Metipred or prednisone, which is better?

The unequivocal answer to the question what is better is not. Both drugs are good enough and cope with the functions assigned to them. Consult before a doctor's appointment, and he will individually prescribe one of these drugs.

Prednisolone instructions for use

The instruction is individual for each person. Also plays an important role form - pills or ampoules.

Pills

In acute condition, you need to drink from 4 to 6 tablets per day - the exact dose is individual. Maintenance dose - 1-2 tablets. With nephrosis and rheumatism, the doses are higher, after which they are gradually reduced.

In ampoules intramuscularly

It can also be administered intravenously into the bloodstream or intramuscularly, including through the introduction of droppers into the blood. In this case, the infusion should be done as deep as possible. With shock, a dose of 30-90 milligrams, with repeated injections - 30-60 mg.

It is recommended to inject 10 mg in small joints, as well as 25 or 50 mg in large ones. The injection must be repeated.

During pregnancy

Pregnancy is on the list of contraindications, therefore, prednisone is prescribed in exceptional cases and is used with extreme caution during pregnancy.

For kids

The calculation for children is the following - about 1-2 milligrams per kilogram of mass per day. The dose is stretched to 4-6 receptions.

Prednisone reviews

The prednisone forums contain hundreds of reviews about why, when and from what should be asked to be prescribed a prescription, and why not. Many people ask where the drug went from the shelves of their pharmacies. Others answer that soon prednisone (in Latin - Prednisolonum) of the new generation should appear, and this one is discontinued.

Reviews are very different. Most of them are positive. Negatives are mainly associated with inattentive reading of the line on side effects in the instructions.

And although this effect is not excluded, it helps in many diseases. It shows full compatibility with all hormones. Many people showed a photo before treatment and the consequences - the difference is visible to the naked eye. It can be easily removed from the body, this is the difference with other substances - they are derived very difficult.

Take the drug and pulse therapy, oncology, pneumonia in bodybuilding. When dieting and taking medication, consider when you need to perform actions of application.

Contraindications

Severe active form of hypertension, diabetes mellitus, pregnancy, psychosis, nephritis, ulcer, osteoborosis, syphilis, tuberculosis, old age. Pregnant women drug is also not recommended.

Side effects

Acne rashes, obesity, osteoporosis, menstrual disorders, hirsutism, Itsenko-Cushing symptom complex, digestive tract expression, hyperglycemia, ulcer perforation, increased clotting, mental disorders.

Alcohol compatibility

These substances are chemically compatible, but they can be used together only in a normal dosage. Then the mechanism of their interaction will not have a big impact on the cells of the liver and the development of the activity of various diseases.

Today it is easiest to order Prednisolone, Cortisone Ternidazole, Acetate, Neomycin, Nystatin, Prednisone, and other drugs through the Internet. In the pharmacies of Kazan, he disappeared from the shelves and is not on sale. Not available and drugs for cats and dogs. However, such a replacement of the place of purchase will have lower costs in comparison with the traditional one. They can send it to you by mail.

Release form

There are several forms of prednisolone, among which are:

  1. Solutionwhich is administered intravenously or intramuscularly. The dosage is 25 mg per one milliliter of solution. The volume of ampoules is 1 ml. The number of ampoules can be different, from 5 to 100 pieces.
  2. There are also tablet form and ointment. In one tablet, the mass of the drug is 5 mg. Packed tablets into blasters, the number of which reaches 10 pieces. One pack can contain up to 100 tablets.

Pharmacokinetics

The main active ingredient of this tool is a synthetic analogue of the hormone produced in humans in the normal, in the area of ​​the adrenal cortex.

That is why this drug can be attributed to drugs of the glucocorticosteroid group.

Prednisolone is administered intramuscularly or intravenously. After its parenteral entry into the body, its rather rapid accumulation in the circulatory system occurs.

As a result, there is a rapid manifestation of its main effects, with the exception of those that are formed as a result of the accumulation of the drug or the advanced stage of the pathological process.

With blood flow, the drug enters the liver tissue, where its inactive decay products of the main active substance are formed. Removal of the drug from the bile is minimal, since the substance is mainly excreted through the renal system.

Pharmacodynamics

Prednisolone contributes to the effects on all types of metabolism:

  1. Effect on protein metabolism. Globulin decreases as one of the protein components of plasma, albumin synthesis in liver cells increases, and synthesis of the protein component in muscle cells decreases in the synthesis of catabolism.
  2. Changes in lipid metabolism. There is an increase in the synthesis of saturated fatty acids, as well as triglycerides, the redistribution of fat from areas of the shoulder, lower back, anterior abdominal wall, as well as the face. There is an increase in cholesterol.
  3. Change in carbohydrate metabolism. There is an increase in the absorption of the carbohydrate component from the digestive system, as well as increasing the output of glucose in the bloodstream, mainly from the liver cells. Gluconeogenesis increases, and severe hyperglycemia is also observed.
  4. Coming decrease in mineralization bones.
  5. Anti-inflammatory effect achieved by reducing the production of cytokines, as well as stabilization of cell membranes. Reduced tissue swelling, as well as a decrease in the formation of antibodies.

All indications for taking the parenteral form of this drug can be divided into two main groups, this is an emergency measure, as well as a preventive measure.

The first should include those situations that, as a rule, develop sharply, and require the elimination of them as soon as possible.

Among them:

  1. State of shock different in origin. This is a burn, toxic, traumatic, cardiogenic, surgical, excessive pain effects. They are accompanied by a disorder of the work of the main vital systems in the body, which is expressed in multiple organ failure, as well as a sharp decrease in blood pressure. Such a condition can be quite quickly, without medical intervention, fatal.
  2. Allergic reaction, severe in its clinical course. It is accompanied in these cases by the development of an anaphylactic reaction, as well as shock. These manifestations include bronchial asthma and asthmatic manifestation in the form of status.
  3. Manifestations of severe cerebral edemaresulting from a traumatic impact, intoxication, as well as a consequence of the transferred operation.
  4. Systemic cell damageincluded in the connective tissue component. As a result, antibodies against their cells are formed by the body. Among them, lupus, rheumatism, rheumatoid arthritis should be highlighted.
  5. Manifestation acute adrenal insufficiency with a change in their functional state, expressed in violation of the content of hormones.
  6. Acute inflammatory damage to the liverwhich is caused by a causal component that is different in its effects and the mechanism of vital activity.
  7. Thyrotoxicstateresulting from increased production of the hormone profile of the thyroid gland, as well as a violation of the ratio of their composition.
  8. With chronic processesthat do not require immediate effect, Prednisolone is used to reduce the manifestations of exacerbation of inflammation, as well as maintenance therapy for chronic conditions such as bronchial asthma, systemic lupus erythematosus, rheumatoid arthritis and other autoimmune diseases.

Another indication for the use of Prednisolone is to include treatment or an obstacle to the formation of cicatricial formations in the place of mechanical impact, as well as burns or other effects.

Contraindications

It should be noted that the presence of contraindications is more necessary only in the selection of drugs outside the acute period. In life-threatening situations, they are not taken into account, since the preservation of life and the elimination of an acute pathological condition is the most important task.

The only contraindication that should be considered in this case is the presence of individual intolerance to the components, a history of Quincke edema or anaphylactic shock, in response to the introduction of Prednisolone.

In the planned use of Prednisolone for the treatment of chronic pathologies, the following contraindications should be highlighted:

  1. Availability inflammatory or destructive ulcerssuch as gastritis, gastroduodenitis, colitis, gastric ulcer or duodenal ulcer, ulcerative colitis, etc. Do not enter Prednisolone for suspected gastrointestinal bleeding.
  2. Suspicion or the presence of an infectious inflammatory processhaving a fungal, viral or parasitic origin. At the same time, it is important to take into account even the presence of a recent contact with an infectious patient. The only permitted case in which it is possible to administer Prednisolone to infectious patients is the presence of a life-threatening condition in the case of complex therapy with antibacterial, antiviral, and antifungal drugs.
  3. Availability immunosuppressive state, in particular, with HIV infection in various stages of its course.
  4. At once after vaccination, before its direct implementation. This is especially true for the introduction of BCG vaccine.
  5. Availability cardiovascular diseases. They may be acute or chronic. Among them are heart attacks, the presence of hypertension, functional insufficiency, atherosclerosis of the vessels, hyperlipidemia.
  6. Revealing endocrine pathologies, such as various options for diabetes, pathology of the thyroid gland and adrenal glands.
  7. Revealing of pregnancy on any of the terms.
  8. Availability osteoporosis, myasthenia, poliomyelitis etc.
  9. Acute condition psychosis or impaired consciousness.

Before you enter the drug you need clarify the presence of contraindications, as well as to evaluate the reaction to the introduction of the initially small amount.

Mode of application

The drug in the injection form should be administered intramuscularly or intravenously.

Initially, Prednisolone starts to be jetted, and later drip intake begins. The drug is available in finished dosage form, and therefore does not require dilution or the addition of additional components:

  1. In case of allergic pathology, the introduction provides for the appointment of a dosage of 100-200 mg for a period of from 3 days to two weeks.
  2. Bronchial asthma involves the introduction of Prednisolone, depending on the severity of the pathological process in different dosages. With a light variant of the course, this is 75 mg, and with a severe course up to 675 mg. The course of therapy can last up to two weeks. In the acute, severe form, the loading dosage of the drug in a mass of up to 1400 mg can be used, and subsequently it is gradually reduced.
  3. When asthmatic status 500–1200 mg is required, a dose reduction of 300 mg is possible.
  4. Acute adrenal insufficiency provides for the introduction of a single dosage of an agent weighing 100-200 mg, per day, no more than 400 mg of Prednisolone is allowed.
  5. Thyrotoxic Crisis - 100 mg once, it is possible to bring the daily dosage to 300 mg. The maximum amount of Prednisolone can be up to 1000 mg. The average duration of therapy is 6 days.
  6. Acute renal, liver failure- daily dose of 25-75 mg, increasing the dosage is acceptable up to 1500 mg.
  7. Rheumatoid arthritis, another autoimmune pathology- 75-125 mg per day. The course of therapy is on average 2 weeks.

Side effect

The appearance of side effects is permissible in the case of increasing the dosage, as well as the wrong dosing regimen.

Among them should be highlighted:

  1. Development steroid diabetes, as well as a decrease in the functioning of the adrenal glands, as well as the development of Itsenko – Cushing syndrome or a delay in sexual development.
  2. Appearance nausea, vomiting, pancreatitis, gastrointestinal ulcer, bleedingas well as disorders of the digestive system.
  3. Development bradycardia, arrhythmias, worsening severity of heart failure, hypercoagulation and thrombosis.
  4. Formation disorientation, delirium, psychosis, depression, insomniaheadaches and cramps.
  5. Possible development of cataracts, exophthalmos, vision loss, as well as increasing the risk of adherence of secondary infections.
  6. Appearance peripheral edema, growth disorders, problems with the healing of wound defects of the skinas well as the formation of striae, hyper or hypopigmentation.
  7. There may be others pathological conditionswhich are attributed to side effects. They are much rarer compared to the above.

Overdose

When using Prednisolone, especially in high therapeutic or loading dosages, symptoms of overdose may occur. Most often they occur when combined with other drugs:

  1. With such drugs that are inducers of the microsomal enzyme apparatus of the liver. Among them should be distinguished drugs phenobarbital, rifampicin, theophylline, etc. With the combination of these drugs there is a decrease in the content of Prednisolone in the blood.
  2. In case of simultaneous reception with thiazide diuretics, and the amphotericin B group increases the risk of aggravating the pathology of the heart to the possible formation of heart failure.
  3. When taken with loop diuretics The risk of osteoporotic diseases increases.
  4. Sodium-containing drugs with the simultaneous use of Prednisolone lead to the development of generalized edema syndrome.
  5. Cardiac glycosidesincluded in therapy with prednisone form ventricular premature beats.
  6. Combination with anticoagulants leads to the development of bleeding.
  7. Nonsteroidal anti-inflammatory drugs increase the formation of ulcers or erosions in the gastrointestinal tract.

These are some of the most frequent side effects, and other conditions can occur. That is why it is important to observe the necessary dosage during the reception, as well as take into account possible contraindications and other conditions.

Storage conditions

The optimal storage temperature of the solution is not exceeding up to 25 degrees. Store the drug should be, avoiding the ingress of sunlight.

The drug can be used within 5 years from the date of manufacture. A prerequisite in this case is compliance with all storage rules.

The drug from the pharmacy is released only if you have a prescription from a doctor.

pharmachologic effect

Pharmacodynamics: the remedy has:

  • anti-inflammatory,
  • antiallergic,
  • immunosuppressive,
  • anti-shock properties.

The steroid hormone complex is delivered to the cell nucleus with the receptor, where it begins to interact with effector elements concentrated on chromatin sites, resulting in a change in messenger RNA and proteins.

Artificial suppression of immunity leads to a decrease in the number of T-lymphocytes and their effect on B-lymphocytes, accelerates the production of immunoglobulins.

Antiallergic action is due to inhibition of the production of allergy provocateurs, reduced development of lymphoid tissue. The product is effective in allergic reactions of rapid type.

Accelerates the breakdown of proteins and reduces their amount in plasma, speeds up gluconeogenesis in the liver and ensures the formation of enzyme proteins, accelerates the synthesis of albumin in the liver and kidneys. Promotes the redistribution of fat, increases the formation of higher fatty acids.

The antishock effect is associated with slowing down the synthesis of platelet activation.

  • binds to plasma proteins by 90-95%,
  • the process of biotransformation occurs in the liver, small intestine, kidneys and bronchi,
  • the half-life of blood takes 3-4 hours, from tissues - 17-36 hours,
  • excreted through the kidneys, crosses the placental barrier.

According to the anatomical and therapeutic chemical classification has the code H02AB06.

What is Prednisolone for?

The drug is used to relieve inflammation of varying severity, reduce body temperature. It is also used as a means to suppress allergic reactions that can threaten a person’s life (angioedema, anaphylactic shock), allergic rhinitis, and dermatitis.

The drug is injected with swelling of the brain, developed as a result of injury, with inflammation and progression of infection, after neurosurgical surgery. It has a beneficial effect in severe burns of the gastrointestinal tract and respiratory tract, severe injuries, is used in severe bronchial asthma, systemic lupus erythematosus, scleroderma, rheumatoid arthritis.

It is prescribed for adrenal hyperplasia, berylliosis, multiple sclerosis, acute hepatitis, hepatic coma and other pathologies. It is used for inhalation with problems with the respiratory system, in ophthalmology, oncology.

Pill application

Treatment with pills for a long time, is used in case of mild conditions.

During replacement therapy, 20-30 mg per day is prescribed for oral administration.

With nephrotic syndrome and rheumatic pathologies, the number of tablets increases. In case of mental disorders, high doses are prescribed in exceptional cases, the treatment takes place under the constant supervision of a physician.

For children, the dose for treatment is 1-2 mg per 1 kg of body weight, divided into 4-6 times a day, 0.3-0.6 mg per 1 kg of body weight is prescribed to maintain the condition, and in the morning most or all of the dose is taken.

Prednisolone ampoules

Injections are given intramuscularly, through a vein or into a joint. The use of ampoules does not provide for the mixing of drugs with other medicines in a syringe or drip.

  1. Adults are administered 4-60 mg per day in a vein or intramuscularly.
  2. Children from 6 to 12 years old infuse 25-25 mg per day, for children over 12 years old this dose is 25-50 mg. It is inserted deep into the gluteus muscle and is used strictly according to the doctor’s prescription and under his control. The course of treatment and the administration scheme are chosen individually.
  3. The diagnosis of Addison's disease dose for an adult - 4-60 mg intramuscularly or intravenously.
  4. Ulcerative colitis is treated for 5–6 days with a means of 8–12 ml per day, with a severe form of Crohn's disease per day, the dose ranges from 10 to 13 ml, the course is 5–7 days.
  5. In severe conditions, slowly administered intravenously (about 3 minutes) or through an IV line, the dose is 30-60 mg. When it is impossible to inject an agent through a vein, it is injected deep intramuscularly. Increasing the dose occurs individually, according to indications.
  6. With intra-articular injection for an adult, the dose for large joints is 30 mg, for medium ones - 10-25 mg, for small ones - 5-10 mg. The procedure is performed after 3 days, treatment - up to 3 weeks.

The tool is applied with a thin layer to the skin up to 3 times per day, lightly rubbed. The course is chosen individually, depending on the disease and the effectiveness of treatment, lasts from 6 to 14 days, no more.

For children older than one year, the treatment lasts 3-7 days, and it is not possible to impose warming and fixing dressings on the site of application of the ointment in order not to cause an increase in the absorption of corticosteroids.

special instructions

It is prescribed with caution in diabetes mellitus. For tuberculosis and other infections, it is prescribed with antibiotics or tuberculostatic drugs.

In the course of treatment, it is necessary to monitor blood pressure and vision, monitor the level of glucose in the blood and urine, and give a stool for occult blood. With the sudden cancellation may develop nausea, lethargy, anorexia.

What is harmful drug?

The tool is a systemic drug, therefore it affects the entire body and, along with its benefits, can have a negative effect on organs and systems. A hormonal agent with a constant intake reduces immunity, therefore, is appointed by short courses.

Prednisolone Cancellation Scheme

At lower doses, the results of blood tests should be considered. The abolition of the drug occurs gradually. After reducing the daily dose to 10 mg per day, the reduction should be less than 1 mg per month. It may be 1 mg at 2 months.

The initial dose is reduced by 2.5 mg every month or up to 10 mg per day every 2 weeks, after that - by 1 mg every 6-8 weeks until complete cessation of treatment.

Side effects

The manifestation of side effects depends on the duration of the course of treatment, the dose and regimen of the drug.

Negative effects can occur from all organs and systems. A person can increase blood pressure, because of the effect of the drug on the production of glucose in patients with obesity, there are problems with weight loss, diabetes is progressing.

There may be numerous problems with digestion, pancreatitis, internal bleeding. Arrhythmia, bradycardia develops, after a heart attack, the area of ​​necrosis increases, the growth of scar tissue slows down, which can lead to a rupture of the heart. Nervous system disorders, euphoria, hallucinations, psychosis occur, intracranial pressure rises, insomnia appears, convulsions, severe headaches, and problems with the cerebellum.

There are problems with the organs of vision: the intraocular pressure rises, which does not exclude damage to the optic nerve, cataracts and secondary infections can develop. In children, the formation of the musculoskeletal system is impaired, adults develop osteoporosis and other problems with bones and cartilage.

Numerous rashes can appear on the skin, healing of the lesions slows down, candidiasis develops. Night urination increases, urolithiasis appears.

A complete list of adverse reactions need to ask your doctor.

Drug interaction

The combination of drugs can have a negative effect on the body.

The following conditions should be considered during treatment:

  1. Ephedrine, Phenobarbital and Theophylline reduce the concentration of the active substance. Combination with diuretics accelerates the excretion of potassium from the body. Sodium-containing drugs increase blood pressure and cause the formation of edema.
  2. Severe bleeding and ulcers in the digestive tract can result from a combination with anticoagulants and thrombolytics. Indomethacin enhances side effects.
  3. The drug enhances the negative effect of Paracetamol on the liver, reduces the effect of insulin intake.
  4. Increased intraocular pressure when used with antidepressants and nitrates.
  5. When using an agent to reduce the activity of the adrenal glands, it may be necessary to increase the dose of the active substance.
  6. They provoke the development of neuroleptic cataracts.
  7. Vaccines containing live viruses increase the risk of viral infections.

During treatment, the doctor takes into account all possible risks of combining drugs.

The following structure has a common structure:

  • Metipred, Dexamed, Dexamethasone,
  • Betamethasone, Diprospan, Maxidex,
  • Floisterone, Kenalog, Hydrocortisone,
  • Suprastin.

Shelf life

Tablets and solution in ampoules are stored for 5 years, the agent in the form of ointment is allowed to use for 2 years.

The price of the drug depends on the manufacturer and the amount in 1 package. Tablets cost from 50 to 700 rubles. Ointment can be purchased at prices ranging from 14 to 450 rubles. Solution for injection is in the range from 20 to 200 rubles, drops - from 50 to 200 rubles.

She took pills for neurology. Negative phenomena are not observed. But before the dose was reduced to 8 tablets per day, there were problems with the fact that there was a constant feeling of hunger, while eating there was no feeling of satiety. I wanted to have an hour after a hearty lunch. Accurately followed the recommendations of the doctor, there were no complications.

My grandmother on the skin showed severe irritation after vitamins. No funds helped until you tried the ointment with prednisone. In the morning, the rash disappeared and the itching stopped. Used with care, because they learned about a large number of contraindications.

Mechanism of action

Prednisolone is an injection solution that has powerful anti-inflammatory, anti-shock, analgesic and immunosuppressive effects. Once in the body, the drug forms a glucocorticoid receptor. It rapidly penetrates into the cell nucleus, where it interacts with genes. Because of this, there are major changes in the production of proteins and RNA. Prednisolone is valued for its high anti-inflammatory effect, which is caused by the following factors:

  • The active ingredients increase the production of lipocortin, which prevents the further production of phospholipase. Because of this, damaged tissue can no longer produce arachidonic acid. All this leads to the impossibility of the synthesis of prostaglandins.
  • The active substances interfere with the COX-2 gene exchange, which also reduces the production of prostaglandins.
  • Prednisolone stops the metabolic processes between molecules in the blood vessels, so that neutrophils and monocytes do not penetrate into the inflammatory focus.

Prednisolone is a drug with powerful anti-inflammatory, analgesic and immunosuppressive effects.

Indications for use

Prednisolone is a powerful medicine, which can be used only after consulting a doctor. Usually experts prescribe it:

  • In case of postoperative, traumatic, toxic and burns shocks.
  • In acute and severe allergies.
  • When anaphylactic or blood transfusion shock.
  • Swelling of the brain due to radiation therapy, head trauma or a tumor.
  • With severe bronchial asthma.
  • In severe lesions of the skin: psoriasis, dermatitis, bullous dermatitis, seborrhea, Stevens-Jones syndrome.
  • With allergic conjunctivitis.
  • With serious disorders and congenital adrenal anomalies.
  • In severe uveitis, optic neuritis.
  • With hepatic coma.
  • In thyrotoxic crisis.
  • With acute hepatitis.
  • With serious diseases of the blood and circulatory system.
  • In Leffler syndrome, berylliosis.
  • With multiple sclerosis.
  • With hypercalcemia caused by malignant neoplasms.
  • As a preventive measure for rejection of a transplanted organ.
  • To reduce inflammation.
  • For the prevention of scar contractions.

Therapeutic dosage

Note that to prescribe a therapeutic dose of Prednisolone, as well as the duration of its use can only the attending physician. He should be familiar with the results of diagnostic studies, and only after that prescribe treatment. Injections can be administered into the body drip or jet, but in practice, two of these methods are used in one procedure.

Despite the generally accepted dosage, prednisolone should be prescribed treatment exclusively by the attending physician on the basis of advanced diagnostic data.

Cancellation syndrome

With prolonged use of the solution for injection Prednisolone, the body begins to get used to the components. In addition, the drug affects and changes the functioning of the adrenal glands. With a sharp refusal of therapy with this drug, a person may experience malaise, increased fatigue, high body temperature. Such conditions disappear without additional therapy for several days. However, if high doses of Prednisolone were abruptly abolished, there is a risk of a hypoadrenaline crisis. You can recognize it by increasing convulsions, vomiting and collapse. If a person does not provide medical assistance in a timely manner, cardiac arrest is possible due to acute cardiovascular failure.

It is strictly forbidden to end abruptly the use of Prednisolone - it is necessary to gradually reduce the therapeutic dose in order to avoid withdrawal syndrome.

Side effects

Prednisolone is a drug that has many side effects. In order to prevent their occurrence, it is necessary to strictly adhere to all recommendations of the attending physician. The most dangerous are the following consequences:

  • Decreased glucose tolerance is especially dangerous for people with diabetes. Substances entering the body slow down the liver, causing insulin production to be disrupted.
  • Inhibition of adrenal function - this leads to hormonal imbalance. Also inhibits the removal of toxins from the body.
  • Itsenko-Cushing syndrome is a condition that is observed with a powerful change in hormonal levels.
  • The appearance of nausea, vomiting, pain in the abdomen.
  • The formation of bleeding inside the digestive tract: erosive gastritis, perforation of the intestinal walls, ulcers.
  • Disturbance of digestion in the form of changes in appetite, constipation and diarrhea, flatulence.
  • Exacerbation of cardiovascular pathologies.
  • The appearance of long hiccups.
  • Changes in the nervous system: TIR, depression, euphoria, paranoia, disorientation.
  • Frequent convulsive seizures, especially at night.
  • Headaches and dizziness.
  • Significant increase in pressure inside the eyes.
  • Increased intraocular pressure, trophic changes in the structure of the cornea.
  • Hyperhidrosis, the appearance of a specific odor from the body.
  • Weight loss, atrophy of muscle tissue.
  • Long healing of wounds.
  • The formation of acne and striae on the body.
  • Local allergic reactions.

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