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Centrum (children's forms of release)

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Centrum is a multivitamin preparation for treating hypovitaminosis and preventing seasonal deficiencies of vitamins and minerals.

Regulates the exchange of calcium and phosphorus, the process of building bone structure, the metabolism of proteins, fats and carbohydrates. Fills the deficiency of vitamins and minerals.

Mg2 + reduces the excitability of nerve cells and neuromuscular transmission, is involved in many enzymatic reactions. Mg2 + deficiency manifests as neuromuscular disorders (myasthenia, tremors, myoclonus, convulsions), mental disorders (insomnia, irritability, anxiety), heart rhythm disorders (extrasystole, tachycardia) and gastrointestinal activity (pain, diarrhea, spasms, intestinal swelling) .

Pyridoxine is involved in the regulation of the metabolism of the nervous system and complements the effect of Mg2 +.

Cyanocobalamin and folic acid are involved in many enzymatic reactions and have a beneficial effect on the nervous and hematopoietic systems.

Vitamin A promotes normal growth, forms and maintains the structure and function of bones, skin and teeth, and participates in the development of visual pigment.

Vitamin C helps to form and maintain the structure and function of various tissues, strengthens capillary and vascular walls.

Vitamin E is necessary for the normal functioning of red blood cells, prevents damage to the cell membranes.

Vitamin B1 is necessary to ensure the full activity of the nervous system and heart.

Vitamin B3 is involved in the regeneration of tissues, especially the skin.

Vitamin K increases blood clotting by increasing the synthesis of prothrombin in the liver.

Pantothenic acid is an important participant in metabolic processes.

Vitamin B6 and B12 support the structure and functions of almost all body tissues, affect erythropoiesis and the nervous system.

Biotin is necessary for the full course of metabolic processes and protein absorption.

Folic acid and iron are involved in erythropoiesis. Also, iron is an important component of hemoglobin, which provides oxygen transport to the structure of tissues.

Iodine is necessary for the synthesis of thyroid hormones and the regulation of metabolic processes.

Copper - regulates the exchange of iron and ensures the normal function of red blood cells.

Manganese - takes part in the process of bone mineralization.

Chromium - promotes the utilization of carbohydrates.

Potassium - is involved in the conduct of the neuromuscular impulse and metabolic processes occurring in myocardial cells.

Selenium - regulates the function of certain enzymes.

Zinc is a component of many enzymes that regulate the synthesis and metabolism of hormones and immune cells.

Boron is necessary for the exchange of magnesium and calcium. Its deficiency can cause the development of physical weakness.

Each Centrum tablet contains 15% of the daily requirement for Mg2 + and 100% of the daily requirement of pyridoxine, cyanocobalamin and folic acid.

  • Coated tablets (Centrum Silver, Silver with Lutein, Materna Multivitamin Complex).
  • Chewable tablets (Centrum Junior Pro, Children + extra calcium, Children + extra vitamin C, Children from A to Zinc Multivitamin complex).

Indications for use

What does Centrum help? According to the instructions, vitamins are prescribed in the following cases:

  • Prevention of vitamin and mineral deficiencies in adults,
  • Inadequate and unbalanced nutrition,
  • Period after prolonged antibiotic therapy,
  • Seasonal prevention of hypovitaminosis.

Instructions for use Centrum dosage

The drug is taken after meals, preferably after breakfast, with clean water.

The standard dosage, according to the instructions for use - 1 tablet Centrum 1 time per day. The standard course for taking vitamins is 30 days.

Exceeding the recommended therapeutic dosage is not recommended, since it can lead to the accumulation of certain vitamins in the body (hypervitaminosis) with impaired functional status of certain organs and systems.

special instructions

Do not exceed the recommended daily dose.

In case of accidental use of high doses of the drug should immediately consult a doctor.

Contains iron, which, in case of overdose, causes the development of side effects.

For periods of pregnancy and lactation, an increased need for the body in vitamins and minerals is characteristic.

The drug should be taken in accordance with the recommendations. The daily dose of vitamin A for pregnant women should not exceed 1 tablet, with an increase in the dosage of Centrum increases the risk of teratogenic effects in the fetus.

Side effects

The instruction warns about the possibility of the development of the following side effects when prescribing Centrum vitamins:

  1. Allergic reactions (skin rash, itching, urticaria).

In the event of side effects requires the abolition of the vitamin complex.

Contraindications

It is contraindicated to appoint the Centrum in the following cases:

  1. Hypersensitivity to the drug.

Concurrent use with other multivitamin preparations is not recommended in order to avoid overdose.

Overdose

Cases of overdose in clinical practice are not registered.

Composition and release form

1 chewable tablet contains:

17 components - vitamin A (retinol acetate) 330 µg, vitamin E (tocopherol acetate) 5 mg, vitamin D3 (cholecalciferol) 3.13 µg, vitamin K1 (phytonadione) 10 µg, vitamin C (ascorbic acid) 50 mg, biotin 50 µg, folic acid 200 nicotinamide 5 mg, pantothenic acid (calcium pantothenate) 2.5 mg, vitamin B1 (thiamine mononitrate) 0.5 mg, vitamin B2 (riboflavin) 0.5 mg, vitamin B6 (pyridoxine hydrochloride) 0.5 mg, vitamin B12 (cyanocobalamin) 1.0 mg , iron (in the form of iron fumarata) 4.5 mg, selenium (in the form of sodium selenate) 12.5 μg, manganese (in the form of sulfate) 0.5 mg, magnesium (in the form of oxide) 4 0mg

Dosage Form:

Description: oval-shaped tablets, film-coated, light peach color. On one side is a risk pill with "C" engraved on the left and "I" to the right of the line. The other side of the tablet is smooth with the engraving "LL".

Composition

  • Vitamin A (retinol acetate and beta carotene) 5000 ME
  • Vitamin E (in the form of dl-α-tocopherol acetate) 30 ME
  • Vitamin C (ascorbic acid) 60 mg
  • Folic acid 400 mcg
  • Vitamin B1 (thiamine mononitrate) 1.50 mg
  • Vitamin B2 (riboflavin) 1.7 mg
  • Biotin 30 mcg
  • Niacinamide 20 mg
  • Vitamin B6 (pyridoxine hydrochloride) 2 mg
  • Vitamin B12 (cyanocobalamin) 6 mcg
  • Vitamin D3 (colecalciferol) 400 ME
  • Pantothenic Acid (D-Calcium Pantothenate) 10 mg
  • Vitamin K1 (as phytonadione) 25 mcg
Minerals
  • Calcium (in the form of phosphate and carbonate) 162 mg
  • Phosphorus (in the form of calcium phosphate) 125 mg
  • Magnesium (in the form of magnesium oxide with sodium borate) 100 mg
  • Iron (in the form of iron fumarata) 18 mg
  • Copper (as copper oxide) 2 mg
  • Zinc (as zinc oxide) 15 mg
  • Silicon (in the form of silicon dioxide) 10 mg
  • Manganese (in the form of manganese sulfate) 2.5 mg
  • Potassium (in the form of potassium chloride) 40 mg
  • Chloride (in the form of potassium chloride) 36.3 mg
  • Chromium (in the form of chromium chloride) 25 mcg
  • Iodide (as potassium iodide) 150 mcg
  • Molybdenum (in the form of sodium molybdate) 25 mcg
  • Selenium (as sodium selenate) 25 mcg
  • Nickel / nickel sulfate 5 µg
  • Tin (as tin (II) chloride) 10 µg
  • Vanadium (as sodium metavanadate) 10 mcg
Excipients
Tablet core:
  • Lactose monohydrate
  • Microcrystalline cellulose
  • Crospovidone
  • Magnesium Stearate
  • Silicon dioxide
  • Stearic acid
Tablet shell:
  • Triethyl citrate Polysorbate 80
  • Dye "Opadray Reas" (hydroxypropylmethylcellulose, 6cP titanium dioxide, D & C yellow 6 lac aluminum).

Pharmacotherapeutic group:

ATX code: A11AA03

Pharmacological properties
Pharmacokinetics
Vitamin A:
Easily absorbed from the gastrointestinal tract. Retinol absorption is reduced in disorders of fat breakdown or absorption and in functional disorders of the liver. Vitamin A is deposited mainly in the liver in the form of palmitic ester and excreted by the kidneys and liver after the formation of a compound with glucuronic acid. Vitamin A improves vision.
Beta caroten:
After absorption, carotenoids are transported through the lymphatic vessels to the liver. Beta-carotene circulates with lipoproteins and can be converted in various tissues to form vitamin A.
Vitamin B1 (thiamin):
Absorbed from the gastrointestinal tract due to Na-dependent active transport. With an increased intake of thiamine, the excess is excreted in the urine. As a coenzyme, thiamin is involved in numerous metabolic reactions.
Vitamin B2 (riboflavin):
Easily absorbed from the gastrointestinal tract due to the presence of a specific transport mechanism, including phosphorylation. Distributed in all tissues. Excess excreted in the urine.
Vitamin B6 (pyridoxine):
Easily absorbed from the gastrointestinal tract and excreted by the liver. It is an essential component for amino acid metabolism and protein building. It plays an important role in the formation of red blood cells and the functioning of the nervous system.
Vitamin B12 (cobalamin):
Absorbed in the intestine with the participation of internal factors. Present in serum in protein bound form.
Biotin:
Easily absorbed from the gastrointestinal tract and excreted in the urine. It is an important component of a number of enzymes and is involved in the metabolism of carbohydrates, fats and proteins.
Folic acid:
Necessary for normal blood formation. It plays an important role in protein metabolism, growth and development.
Niacinamide:
It is easily absorbed from the gastrointestinal tract and is distributed to all tissues. In unchanged form, a small amount of vitamin is present in the urine. Participates in the process of formation of energy in the cells and is useful for the heart, nervous system, muscle function and growth.
Pantothenic acid:
Easily absorbed from the gastrointestinal tract. Present in all tissues. After absorption of 70% of pantothenic acid excreted in the urine. It is an important factor for the metabolism of carbohydrates, fats and amino acids.
Vitamin C:
Ascorbic acid is present in the plasma and in all cells of the body. Promotes iron absorption. Excreted in the urine. Contributes to the acceleration of wound healing, is involved in the process of blood formation.
Vitamin D:
Easily absorbed from the gastrointestinal tract. With impaired fat absorption, vitamin D absorption may decrease. Vitamin D stocks are deposited in the liver and adipose tissue. Metabolized and excreted by the liver. It helps strengthen bones and teeth and regulates the content of calcium and phosphorus.
Vitamin E:
Easily absorbed from the gastrointestinal tract. With impaired fat absorption, vitamin E absorption may decrease. Metabolized and excreted by the liver.
Vitamin K1:
Vitamin K ingested with food is absorbed in the small intestine, is incorporated into the chylomicrons and enters the circulatory system with lymph. Vitamin K decomposition products1 excreted in the urine and feces. Essential for blood clotting.
Minerals:
Calcium:
Vitamin D-dependent transport and facilitated diffusion are absorbed from the intestines. 99% of the calcium contained in the body, in crystalline form, are part of the skeleton. The main component of bones and teeth.
Chloride:
Necessary to maintain water and electrolyte balance in the body.
Chromium:
Chromium is an insulin cofactor. Forms a complex with insulin receptors, facilitating the addition of an insulin complex containing nicotinic acid, glycine, glutamic acid and cysteine. Activates the enzymes involved in the formation of fatty acids and in the assimilation of carbohydrates.
Copper:
Enzymes, which include copper, are involved in many metabolic reactions, for example, in the use of oxygen during cell respiration and energy expenditure. In addition, copper is a component of proteins and enzymes. Copper is involved in iron metabolism, maintaining healthy bones, protein synthesis, as well as pigmentation of the skin, hair and eyes.
Iodine:
Before absorption in the gastrointestinal tract, iodine is recovered from the image, by the injection of iodide. Excreted mainly with urine in the form of iodides.
Iodine is important for the normal functioning of the thyroid gland. It binds to the hormone thyrotropin, which controls metabolism and body temperature.
Iron:
Absorbed from the gastrointestinal tract. It is deposited in the spleen, liver and bone marrow. & frac23, iron is excreted from the gastrointestinal tract, the remaining third is excreted in the urine. Iron in red blood cells binds oxygen.
Magnesium:
Absorbed from the small intestine using active and passive transport. 50% of the magnesium contained in the body is localized in the bone tissue. Excreted mainly by the kidneys. Magnesium is vital for the metabolism of proteins, fats and carbohydrates and is involved in the processes of energy conversion.
Manganese:
The relative amount of manganese absorbed in the body from food is not constant, but varies depending on the diet. With increasing food intake, suction efficiency is clearly reduced. Manganese is almost completely excreted in the feces and only in trace amounts can it be found in the urine. Manganese activates enzymes and is involved in the metabolism of carbohydrates and fats.
Molybdenum:
Molybdenum acts as a cofactor of enzymes. After ingestion is absorbed from 35 to 80% molybdenum. After absorption, most of the molybdenum is rapidly converted and excreted in the form of molybdate by the kidneys. Molybdenum activates enzymes involved in the metabolism of carbohydrates, fats and iron.
Nickel:
Under normal conditions, after oral administration, 20% to 25% of the prescribed nickel dose is absorbed. Some foods, including milk, coffee, tea, orange juice and ascorbic acid, suppress this active absorption of nickel. Nickel is necessary for the normal development of the body.
Phosphorus:
Phosphorus is of great importance for the construction of bones and teeth, as well as for the functioning of the nervous and muscular tissue. In addition, this element plays a crucial role in the transformation of energy and its use in the body.
Potassium:
Easily absorbed from the gastrointestinal tract. Potassium is involved in the transmission of nerve impulses, regulates skeletal muscle contractility.
Selenium:
Possesses antioxidant agents, prevents the formation of free radicals.
Silicon:
Silicon is involved in bone calcification. Some evidence indicates the ability of silicon to perform a catalytic function.
Tin:
Participates in protein synthesis, growth regulation.
Vanadium:
Less than 5% of vanadium from food is absorbed in the body. Under normal conditions, after absorption, only a small part of vanadium remains in the body.
Zinc:
Partially absorbed from the gastrointestinal tract. Zinc is a component of many enzymes and is often simultaneously an activator of these enzymes. Included in several vital hormones, including insulin. In addition, zinc is necessary for taste sensation, wound healing, protein metabolism and night vision.

Indications for use

  • Prevention of hypovitaminosis and mineral deficiency in adults (including seasonal).
  • The state of increased need for vitamins and minerals:
    • unbalanced and inadequate nutrition,
    • recovery period after prolonged illness, antibiotic therapy.

Contraindications
Hypersensitivity to the drug.

Dosage and administration
1 tablet per day, preferably after breakfast, without chewing and washing down with enough water. The course is 30 days.

Side effects
Allergic reactions are possible.

Interaction with other drugs
It is not recommended to take other multivitamin preparations at the same time in order to avoid overdose.

Pregnancy and lactation
For periods of pregnancy and lactation, an increased need for the body in vitamins and minerals is characteristic. The drug Centrum should be taken in accordance with the recommendations. The daily dose of vitamin A for pregnant women should not exceed 1 tablet, with increasing dosage increases the risk of teratogenic effects in the fetus.

special instructions
Do not exceed the recommended daily dose.
In case of accidental use of high doses of the drug should immediately consult a doctor.
It contains iron, which, when overdosing, causes the development of side effects.

Release form
30, 60 or 100 tablets are packed in a bottle of white non-transparent high-density polyethylene (HDPE), closed with a screw-on cap of opaque polypropylene (PP) and a safety valve under the cap. On 1 bottle place in a cardboard pack together with the instruction for application.

Shelf life
3 years. Do not use after the expiration date printed on the package.

Storage conditions
At a temperature not higher than 25 ° С in a dry place.
Keep out of the reach of children.

Analogs Centrum, price in pharmacies

If necessary, it is possible to replace the Centrum vitamins with a counterpart for therapeutic effects - these are the drugs:

  1. Vitaspectrum,
  2. Vitrum,
  3. Duovit,
  4. Kaltsinova,
  5. Complite
  6. Menopace
  7. Multi Tabs
  8. Neurocomplex,
  9. Pikovit
  10. Watering
  11. Pregnavit,
  12. Selmevit,
  13. Supradin,
  14. Centrum Silver,
  15. Elevit Pronatal,
  16. Unicup

Matches for ATH code:

Choosing analogues it is important to understand that the instructions for use of Centrum, the price and reviews, do not apply to vitamins of similar action. It is important to consult a doctor and not to make an independent replacement of the drug.

Price in Russian pharmacies: Centrum from A to Zinc 30 tabl. - from 492 to 621 rubles, according to 739 pharmacies.

Store in a dry, dark place and out of reach of children at a temperature of + 15 ... + 30 ° С. Shelf life - 3 years.

Description of the dosage form, composition

Centrum tablets are coated with an enteric film coat. They are orange and oval. The composition of the drug as the main active ingredients include vitamins and minerals, their content in one tablet is:

  • Iron - 4 mg.
  • Magnesium - 100 mg.
  • Iodine - 150 micrograms.
  • Copper - 2 mg.
  • Phosphorus - 125 mg.
  • Calcium - 200 mg.
  • Zinc - 15 mg.
  • Manganese - 5 mg.
  • Molybdenum - 25 mcg.
  • Potassium - 80 mg.
  • Chrome - 100 mcg.
  • Chloride - 72 mg.
  • Selenium - 25 mcg.
  • Nickel - 5 mcg.
  • Tin - 10 mcg.
  • Silicon - 10 micrograms.
  • Vanadium - 10 mcg.
  • Ascorbic acid - 90 mg.
  • Folic acid - 400 mcg.
  • Biotin - 45 mcg.
  • Thiamine - 2.25 mg.
  • Pantothenic acid - 10 mg.
  • Riboflavin - 3.2 mg.
  • Nicotinamide - 40 mg.
  • Pyridoxine - 3 mg.
  • Cyanocobalamin - 25 mcg.
  • Retinol - 3000 IU (international units).
  • Betacarotene - 3000 IU.
  • Colecalciferol - 400 IU.
  • Tocopherol - 45 IU.

Also in the composition of the tablets are auxiliary additional compounds, which include stearic acid, triethyl citrate, microcrystalline cellulose, magnesium stearate, dye, crospovidone, lactose monohydrate, siloid. Centrum tablets are packaged in plastic jars of 30 pieces. A carton pack contains one bottle with the appropriate number of tablets, as well as instructions for use.

Pharmacological effects

Centrum tablets contain in their composition all the necessary vitamins and minerals for the body. These compounds are part of almost all enzymatic systems of the human body. They affect the functional state of tissues, organs, the synthesis of hemoglobin, hormones, cell division. The use of the drug with a deficiency of vitamins and minerals in the body helps to restore the functional state of all organs and systems. After taking the Centrum tablet inside, all the active components are absorbed at different rates into the systemic circulation, are evenly distributed in the tissues and are included in the metabolic processes of the cells. Excess vitamins or minerals are partially excreted in the urine or accumulate in the tissues.

The main medical indication for taking Centrum tablets is vitamin and mineral deficiency in adults, regardless of gender. Also, the drug is used for unbalanced poor nutrition, after prolonged antibiotic therapy, for the prevention of seasonal vitamin deficiency associated with their reduced content in food (winter-spring period of the year).

Contraindications

The only absolute contraindication for taking Centrum tablets is individual intolerance to any of the components of the drug. Before you start taking the Centrum tablets, it is important to make sure that there are no contraindications.

Centrum tablets are intended for oral administration (oral administration). They are taken with food, not chewed and washed down with plenty of water. The average recommended therapeutic dosage for adults is 1 tablet 1 time per day. The average duration of a course of therapy varies from 25 days to several months, depending on the nature and severity of the vitamin or mineral deficiency.

Side effects

In general, Centrum tablets are well tolerated. Sometimes on the background of the use of this drug develop allergic reactions in the form of a skin rash, its itching, the appearance of a characteristic swelling and rash, resembling a stinging nettle (urticaria). In this case, taking the Centrum pill should be stopped and consult a doctor.

Features of use

Before you start taking the Tsentrum tablets, you must carefully read the annotation to the drug, and also pay attention to a few special instructions:

  • Primarily, this tool refers to dietary supplements and is not used for the treatment of pathological processes as monotherapy.
  • Taking tablets Centrum does not replace a rational and balanced diet with sufficient intake of natural vitamins from food.
  • Exceeding the recommended therapeutic dosage is not recommended, since it can lead to the accumulation of certain vitamins in the body (hypervitaminosis) with impaired functional status of certain organs and systems.
  • While taking Centrum tablets, it is possible to stain urine in a rich yellow color. This is not a pathological condition and does not require the abolition of this tool.
  • Reception of other vitamin complexes against the background of application of this biologically active additive is excluded.
  • If it is necessary to take Tsentrum tablets for pregnant women, it is necessary to consult a doctor, since they include vitamin A, which can have a negative effect on the development of the fetus.
  • The drug is not intended for use in children.
  • The components of the drug do not affect the state of the nervous system, the ability of a person to concentrate, as well as the speed of psychomotor reactions.

In the pharmacy network, Centrum tablets are sold without a prescription. Before starting their admission, it is recommended to consult with a medical specialist.

The composition of the drug centrum children

The composition of the vitamin complex includes: vitamin A, vitamin E, vitamin C, vitamin K1, folic acid, pantothenic acid, vitamins B1, B2, B6 and B12, niacinamide, vitamin D3, biotin, iron, calcium, magnesium, manganese, selenium.

Additional components: xylitol, polydextrose, citric acid, MCC, aspartame, stearic acid, magnesium stearate, silicon dioxide, crimson dye, flavor identical to natural.

children centrum - Instructions for use

Chewable tablets are intended for ingestion, along with food.

For children 4-7 years old, appoint one tablet, to receive every other day.

For children from 7 years old, one chewable tablet is prescribed daily.

The duration of taking the vitamin complex is 1 month.

Before use, you need to consult a pediatrician.

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